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In this episode of Memory Not Found, we deep dive into the unsettling but fascinating world of dementia—because apparently losing your keys every day might not be just a quirky personality trait. We break down what dementia actually is, explore its early symptoms, and go over the different types like Alzheimer’s disease, Lewy body dementia, vascular dementia, and the lesser-known but very real Korsakoff syndrome, an alcohol-related form of dementia (cheers?).

We spotlight new findings from the long-term ARIC study, which reveals a rising risk of dementia in adults, and explore what your brain might be up to without your permission. Plus, we get nerdy with a cutting-edge research tool: the Dunedin Pace of Aging Calculated from NeuroImaging (DunedinPoAmCI or PACNI)—which sounds like a supervillain algorithm but is actually helping scientists predict cognitive decline before it shows up.

No, there’s still no cure for dementia, but we talk about promising developments on the horizon, risk factors you might actually control (spoiler: your liver might be involved), and why your brain might be aging faster than your Netflix algorithm thinks you should.

If you’re into brain health, cognitive decline research, neurodegenerative diseases, or just love learning dark truths with a nervous laugh—this one’s for you.

Resources

https://www.nih.gov/news-events/nih-research-matters/risk-future-burden-dementia-united-states

https://www.mayoclinic.org/diseases-conditions/dementia/symptoms-causes/syc-20352013

https://www5.cscc.unc.edu/aric9/

https://www.alz.org/alzheimers-dementia/what-is-dementia/types-of-dementia/korsakoff-syndrome

https://www.medscape.com/viewarticle/single-brain-mri-reveals-accelerated-aging-dementia-risk-2025a1000ido

https://www.nature.com/articles/s43587-025-00897-z

https://med.stanford.edu/news/all-news/2023/09/stem-cell-alzheimers.html

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