Episode 239 - New Study: Intermittent Fasting increased autophagy and increased tumor suppressor P53!

Get Lean Eat Clean

This week I discuss a new study in which twenty-five healthy young males were recruited and performed 17–19 h/day fasting for 30 days.

In this explanatory study, Ramadan fasting (RF) was used to investigate the effects of prolonged IF on autophagy, inflammasome, and senescence activity in mRNA levels. Main conclusions from the study were the following:

• Fasting 17 to 19 hours per day for 30 days increased autophagy and increased tumor suppressor P53.
• Autophagy increased, favorable changes were made in the inflammasome hub, and there was a decrease in senescence-associated-signaling molecules.
• P53 helps repair DNA damage, prevents senescence, and contributes to reduced atherogenic risk.

One downside of the study was the fact that none of the participants' sleeping, eating, and exercise habits were recorded which might influence autophagy, inflammasome, and senescence mRNA expression.

Either way, I thought this would be an interesting study to share and if you have any questions feel free to email me at [e-mail]. Have a great week!

Episode Resources:

https://www.sciencedirect.com/science/article/pii/S2666149723000063

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