How Breast Cancer’s Tumor Microenvironment Evolves During Treatment: New Insights for Personalized Therapy

The Onco Life Podcast

A new study reveals how breast cancer’s tumor microenvironment (TME) changes during chemotherapy, reshaping immune cells, fibroblasts, and blood vessels. These findings provide fresh insight into why some patients respond better to treatment and how future therapies can be more personalized.

In this episode, you will learn:

• Why breast tumors act like ecosystems of different cell types
• How chemotherapy can reprogram immune cells to either fight or protect against cancer
• The role of cancer-associated fibroblasts in creating treatment barriers
• How endothelial cells reshape blood vessels and form resistant niches
• Why spatial “cellular neighborhoods” can predict patient outcomes
• How co-targeting the TME with immunotherapy or antifibrotic drugs may improve results
• The future role of single-cell and spatial omics in breast cancer care

This episode highlights a paradigm shift in oncology, showing how understanding the TME can lead to smarter, more effective treatment strategies.

Blog Link: How Breast Cancer’s Tumor Microenvironment Evolves During Treatment

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Author: Dr. CHRISTINA NG VAN TZE

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