Inside Microsoft's AI Superfactory with Scott Guthrie

The Neuron: AI Explained

In this episode, we sit down with Scott Guthrie, EVP of Microsoft's Cloud + AI Group, to explore the architecture behind Azure's AI Superfactory. Scott oversees Microsoft's hyperscale cloud computing solutions including Azure, generative AI platforms, and next-generation infrastructure. We dive into Microsoft's strategic approach to AI datacenter buildout, the innovative Fairwater architecture with its 120,000+ fiber miles of AI WAN backbone, and how Microsoft is balancing performance, sustainability, and cost at planet-scale. From dense GPU clusters drawing 140kW per rack to closed-loop liquid cooling systems, Scott reveals the engineering trade-offs behind infrastructure that powers frontier AI models with trillions of parameters. Whether you're an enterprise leader planning AI adoption or a developer curious about cloud architecture, you'll leave understanding how Microsoft is executing on next-gen infrastructure that transforms global challenges into opportunities.

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