Episode 18: DNA Recorders

Preprints in Motion

This week we discuss DNA recorders with Theresa Loveless (@TheresaLovele12), a Post Doc, at UC Irvine. DNA recorders can turn transient events into stable genomic ones and have been used to investigate cell fates and lineages. Join us as we find out more about how this is achieved and the incredible technology behind it!! We also chat about Theresa’s experience of preprinting and academia, and how it can be improved!!

Read the full preprint
https://www.biorxiv.org/content/10.1101/2021.11.05.467507v1.full

Whole-organism lineage tracing by combinatorial and cumulative genome editing: https://pubmed.ncbi.nlm.nih.gov/27229144/

molecular recordings by directed crispr spacer acquisition
https://pubmed.ncbi.nlm.nih.gov/27284167/

Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts
https://pubmed.ncbi.nlm.nih.gov/33479121/

Prime Editor: https://www.nature.com/articles/s41434-021-00263-9
This episode was produced by Emma Wilson and edited by John D Howard .

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Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).