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المحتوى المقدم من Andrew Hattersley and Maggie Shepherd, Andrew Hattersley, and Maggie Shepherd. يتم تحميل جميع محتويات البودكاست بما في ذلك الحلقات والرسومات وأوصاف البودكاست وتقديمها مباشرة بواسطة Andrew Hattersley and Maggie Shepherd, Andrew Hattersley, and Maggie Shepherd أو شريك منصة البودكاست الخاص بهم. إذا كنت تعتقد أن شخصًا ما يستخدم عملك المحمي بحقوق الطبع والنشر دون إذنك، فيمكنك اتباع العملية الموضحة هنا https://ar.player.fm/legal.
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Travis Makes Money
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1 Make Money with AI Appointment Setting | Matt Deseno 32:38
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Matt Deseno is the founder of multiple award winning marketing businesses ranging from a attraction marketing to AI appointment setting to customer user experience. When he’s not working on the businesses he teaches marketing at Pepperdine University and he also teaches other marketing agency owners how they created a software company to triple the profitability for the agency. Our Sponsors: * Check out Kinsta: https://kinsta.com * Check out Mint Mobile: https://mintmobile.com/tmf * Check out Moorings: https://moorings.com * Check out Trust & Will: https://trustandwill.com/TRAVIS * Check out Warby Parker: https://warbyparker.com/travis Advertising Inquiries: https://redcircle.com/brands Privacy & Opt-Out: https://redcircle.com/privacy…
One in Six Billion
وسم كل الحلقات كغير/(كـ)مشغلة
Manage series 3528389
المحتوى المقدم من Andrew Hattersley and Maggie Shepherd, Andrew Hattersley, and Maggie Shepherd. يتم تحميل جميع محتويات البودكاست بما في ذلك الحلقات والرسومات وأوصاف البودكاست وتقديمها مباشرة بواسطة Andrew Hattersley and Maggie Shepherd, Andrew Hattersley, and Maggie Shepherd أو شريك منصة البودكاست الخاص بهم. إذا كنت تعتقد أن شخصًا ما يستخدم عملك المحمي بحقوق الطبع والنشر دون إذنك، فيمكنك اتباع العملية الموضحة هنا https://ar.player.fm/legal.
A podcast about diabetes and genes hosted by Andrew Hattersley and Maggie Shepherd.
34 حلقات
وسم كل الحلقات كغير/(كـ)مشغلة
Manage series 3528389
المحتوى المقدم من Andrew Hattersley and Maggie Shepherd, Andrew Hattersley, and Maggie Shepherd. يتم تحميل جميع محتويات البودكاست بما في ذلك الحلقات والرسومات وأوصاف البودكاست وتقديمها مباشرة بواسطة Andrew Hattersley and Maggie Shepherd, Andrew Hattersley, and Maggie Shepherd أو شريك منصة البودكاست الخاص بهم. إذا كنت تعتقد أن شخصًا ما يستخدم عملك المحمي بحقوق الطبع والنشر دون إذنك، فيمكنك اتباع العملية الموضحة هنا https://ar.player.fm/legal.
A podcast about diabetes and genes hosted by Andrew Hattersley and Maggie Shepherd.
34 حلقات
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One in Six Billion
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1 Special episode 5. John Dennis. Research breakthrough in Type 2 diabetes treatment. 24:01
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Send us a text We talk to John Dennis, a data science researcher working in the University of Exeter. He used data from 1 million people with Type 2 diabetes to discover how the clinical characteristics of a patient alter the glucose lowering with different treatments. John’s 5 drug model, published in the Lancet in late February 2025, uses simple clinical information to identify, for the first time, the best glucose lowering treatment for a patient. The model selected best treatment lowers the glucose most, doubles the time before another medication is needed and reduces long term complications of diabetes. See www.1in6b.com for more details.…
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One in Six Billion
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1 Series 3 Episode 10. Julie Reynolds and Kash Patel. Maternally inherited diabetes and deafness 33:05
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Send us a text Julie Reynolds describes how she gradually lost her hearing in her 30’s and developed diabetes in her 40’s these 2 conditions also developed in in her mother, her children and other maternal relative. This led to a diagnosis of maternally inherited diabetes and deafness that results from a change in the mitochondrial DNA. Kash Patel explains the science between diabetes, deafness and a maternal inheritance and why there is a lot of variation in the presence and severity of clinical features…
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One in Six Billion
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1 Series 3 Episode 9. Ru Kovvuri and Rhian Clissold Cognitive and medical impacts of the HNF1B deletion syndrome 37:44
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Send us a text Ru Kovvuri explains about her battle to get a diagnosis and support for her daughter who had multiple medical problems and learning difficulties as a result of a deletion of the HNF1B gene. Rhian Clissold discusses her research to improve the diagnosis of the HNF1B syndrome and recognise the associated learning difficulties seen with loss (deletion) but not the spelling mistakes (mutations) in the HNF1B gene.…
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One in Six Billion
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1 Series 3 episode 8. HNF1Beta syndrome: kidney disease, diabetes, liver dysfunction and much more 48:13
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Send us a text Grant King talks about his diagnostic journey where his low birth weight, childhood kidney disease, diabetes, liver dysfunction and infertility were at 32 years finally recognised as all being due to a change in the HNF1Beta gene. Dr Coralie Bingham explains how her research during her PhD in Exeter led to HNF1Beta being established as the commonest cause of inherited kidney disease and all the key parts of the HNF1Beta syndrome being recognised.…
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One in Six Billion
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1 Series 3 episode 7. Natalie Raphael and Alice Hughes Testing fetal genetics using mum’s blood in Glucokinase pregnancy 37:05
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Send us a text Natalie Raphael was diagnosed as having glucokinase MODY at the end of her first pregnancy. In her second pregnancy she had a recently introduced blood test that showed her fetus had not inherited her change in the glucokinase gene so was at risk of growing large. As a result of this she was given long-acting insulin to lower her glucose. Alice Hughes is the researcher who did the key study that proved the new blood test was both practical and accurate in glucokinase pregnancy.…
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One in Six Billion
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1 Series 3 episode 6. Gill Preston, Gill Spyer, and Ali Chakera The challenge of diagnosing and managing glucokinase MODY in pregnancy 37:38
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Send us a text It was a great surprise for Gill Preston, who was active and slim, when she was diagnosed with gestational diabetes in her first pregnancy. Her raised fasting glucose did not come down with tablets or insulin. Luckily she met Andrew Hattersley in the diabetes pregnancy clinic, who recognised she had glucokinase MODY. Gill Spyer, working for her PhD as a research doctor showed that in glucokinase pregnancy the size of the baby depended on whether they inherited the genetic change from the mother and was not altered by insulin treatment. When the baby had the mutation it would grow normally and no treatment of the mother was needed. Ali Chakera continued research into glucokinase pregnancy; his research showed that slim women ( BMI <25) with a raised fasting glucose of above 5.5mmol/l had a 1 in 3 chance of having GCK MODY and should be tested. He also looked into genetic testing the fetus directly rather than trying to infer from fetal growth on ultrasound.…
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One in Six Billion
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1 Series 3 episode 5. Andrew Lotery and Amanda Stride: Glucokinase MODY – a mildly raised fasting glucose for life that should not be treated 32:38
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Send us a text In this episode we talk to Andrew Lotery about how he was found to have a raised fasting glucose on an insurance medical. He was treated as Type 2 diabetes but he questioned this as he was young. slim and physically fit. A chance reading of a research funder’s newsletter led him to the Exeter team and a diagnosis of glucokinase MODY. Amanda Stride worked as a research registrar in Exeter. She showed that in glucokinase MODY the fasting glucose was raised from birth and remained stable and regulated throughout life with treatment not changing the blood glucose. Anna Steele showed in her PhD that patients with glucokinase MODY did not get complications affecting the eye or kidney even after 50 years of raised glucose. So in glucokinase MODY treatment with insulin or tablets is not needed and does not work; patients should be discharged and not followed up.…
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One in Six Billion
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1 Series 3 episode 4. Janette and Alice: Big babies with dangerously low blood sugars in HNF4A MODY 33:54
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Send us a text In this episode we talk to Janette and her daughter Alice who were both correctly diagnosed with HNF4A MODY having been initially told they had Type 1 diabetes. The diagnosis not only allowed them to stop insulin but also explained the mystery of two of Jeanette’s children that were born as large babies and collapsed soon after birth with low blood sugar. Andrew explains how it was discovered that babies that inherited the HNF4A genetic change were on average over 800g heavier and were at high risk of low blood glucose around birth…
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One in Six Billion
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1 Series 3 episode 3. Mary Lee and Ewan Pearson: Finding the best treatment for HNF1A MODY 27:48
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Send us a text Mary Lee was thought to have Type 1 diabetes for over 3 decades; she was finally diagnosed with HNF1A MODY and was able to stop her insulin injections and get excellent blood sugar control with a sulphonylurea tablet. We hear from Ewan Pearson how sulphonylurea tablets were found to be excellent glucose lowering treatment when Andrew’s clinical observations of his HNF1A MODY patients were followed up by Ewan with a clinical trial.…
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One in Six Billion
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1 Series 3 episode 2. Kevin Colclough and Bev Shields Making sure the right patients get the right genetic test for MODY 26:25
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Send us a text Kevin Colclough describes how the genetic testing in diabetes has improved over the 2 decades he has worked in the Exeter NHS diagnostic lab. His work means now over 60 types of single gene diabetes are looked for in one sequencing test. Bev Shields talks about how she developed the amazing MODY calculator that uses common clinical characteristics to work out how likely a person with diabetes is to have maturity onset diabetes of the young (MODY).…
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One in Six Billion
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1 Series 3 episode 1. Mary Humphries: The doctor didn’t listen! A delayed diagnosis of MODY 29:01
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Send us a text Mary Humphries tells how her son Dan was diagnosed with diabetes aged 16 and it was assumed he had type 1 diabetes and treated with insulin. On insulin he had terrible problems with low blood sugars frequently losing consciousness and not managing to concentrate at school or at home. Mary was very worried that he was getting worse on the insulin and asked about genetic tests because she had recently been diagnosed with Type 2 diabetes and there was diabetes in all generations of her family. She was not listened to; the insulin was continued, and Dan got worse. Searching the internet for answers she found the Exeter diabetesgenes.org website which led her to talking to Andrew and Maggie. They were able to rapidly diagnose that this was Maturity-onset Diabetes of the Young (MODY), subtype HNF1A . with a genetic test. Maggie helped Dan to stop his insulin and get excellent control on a quarter of the sulphonylurea tablet called gliclazide. Dan rapidly improved off the insulin and passed his A levels with flying colours going to Bristol where he achieved his life’s ambition to become a large animal vet.…
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One in Six Billion
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1 Series 2 episode 9. Nick Thomas. Type 1 diabetes in the older adult 24:04
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Send us a text Dr Nick Thomas talks about Type 1 diabetes in the older adult. In an iconoclastic study he showed most cases of Type 1 diabetes occur in adults rather than children. In older adults it is very hard to recognise as 98-99% of people with diabetes have Type 2 diabetes. Older adults with Type 1 diabetes have just as rapid a decline in their own insulin and need all the expert care offered to children.…
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One in Six Billion
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1 Series 2 episode 8. Simon Goode and Angus Jones. Diagnosing Type 1 diabetes is difficult in older adults 38:57
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Send us a text Simon Goode was diagnosed with Type 2 diabetes aged 28. He explains how it took 6 months of feeling unwell before it was realised he had Type 1 diabetes instead. Exeter Professor, Angus Jones, has done research showing that mistakes in the diagnosis Type of 1 diabetes are common in the older adult and offers solutions to help doctors get the diagnosis right.…
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One in Six Billion
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1 Series 2 Episode 7. Jean Claude Katte. Type 1 Diabetes in Africa: different in so many ways. 35:45
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Send us a text Dr Jean Claude Katte explains how in Sub Saharan Africa diagnosis, treatment and monitoring of Type 1 diabetes in children and young adults is so much harder than in Europe. He discusses with Maggie and Andrew his own exciting research that has shown that around 60% of African children with diabetes do not have the typical autoimmune Type 1 diabetes seen in over 90% of children with diabetes in Europe. Jean Claude aims to do more research to discover what causes this new cause of severe young-onset diabetes in Sub Saharan Africa.…
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One in Six Billion
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1 Series 2 episode 6. Mendy Korer and Matt Johnson. Type 1 diabetes in very young children: a massive challenge for families and scientists 47:35
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Send us a text We hear from Mendy Korer about the enormous challenges of living with a child who was diagnosed with Type 1 diabetes aged 11 months. Matt Johnson, a research fellow in Exeter talks about his exciting work understanding what makes the immune system destroy the insulin making beta-cells in very young children.…
مرحبًا بك في مشغل أف ام!
يقوم برنامج مشغل أف أم بمسح الويب للحصول على بودكاست عالية الجودة لتستمتع بها الآن. إنه أفضل تطبيق بودكاست ويعمل على أجهزة اندرويد والأيفون والويب. قم بالتسجيل لمزامنة الاشتراكات عبر الأجهزة.