106: Potential Role of Stathmin-2 in Amyotrophic Lateral Sclerosis

NeurologyLive® Mind Moments®

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In this episode, Cathleen Lutz, PhD, vice president of the Rare Disease Translational Center at the Jackson Laboratory, provided comment on a recently published study which unveiled that stathmin-2 loss leads to neurofilament-dependent axonal collapse in patients with amyotrophic lateral sclerosis (ALS). Lutz offered insight on the role stathmin-2 may have in this disease, the questions that still remain, and whether restoration of stathmin-2 may be an attractive therapeutic approach. Furthermore, she spoke on the potential of this protein as a disease-modifying biomarker and whether it may be incorporated in trials in the near future.
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Episode Breakdown:

• 1:15 – Idea behind studying stathmin-2
• 2:45 – Overviewing study results
• 7:05 – Next steps in extending this research
• 8:40 – Neurology News Minute
• 11:30 – Stathmin-2's connection with neurofilament light
• 12:55 – Potential of stathmin-2 as ALS-specific biomarker
• 14:45 – Future use of stathmin-2 in clinical trials
• 15:30 – Closing thoughts

This episode is brought to you by Medical World News, a streaming channel from MJH Life Sciences®. Check out new content and shows every day, only at medicalworldnews.com.
The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here:

• FDA Clears Phase 2 KYSA-7 Study of CAR T-Cell Therapy in Refractory Progressive Multiple Sclerosis

• Dyne Reports Positive Phase 1/2 Data for Duchenne Agent DYNE-251

• Parkinson Gene Therapy AB-1005 Meets Primary End Point in Phase 1b Trial

• VISIONARY-MS Trial Reports CNM-Au8 Improves Vision and Cognition in Multiple Sclerosis

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