#062: Dimethyl fumarate (Tecfidera) and Diroximel fumarate (Vumerity) for relapsing remitting multiple sclerosis

MS-Perspektive - The Multiple Sclerosis Podcast

Tecfidera and Vumerity, the fumarates kick-off the informative series about immunotherapy for multiple sclerosis.

You can find the full article to read on my blog: https://ms-perspektive.com/62-fumarates

Tecfidera and Vumerity, the fumarates, kick off the series on the approved disease-modifying therapies for MS. I am trying to give a good overview, but it does not claim to be complete information. The order is simple. It starts with a rather broad mechanism of action, which works for a good proportion of those affected, through to the increasingly specific mechanisms of action, which work for the majority of all MS patients. Detailed advice can only be given by MS specialists and cannot be provided by me.

Table of Contents

• General Information
• How are dimethyl fumarate (Tecfidera) and diroximel fumarate (Vumerity) classified in immunotherapies?
• What are dimethyl fumarate (Tecfidera) and diroximel fumarate (Vumerity) approved for?
• What is the situation for special patient groups?
• Who should avoid dimethyl fumarate (Tecfidera and generics) and diroximel fumarate (Vumerity)?
• How do dimethyl fumarate (Tecfidera and generics) and diroximel fumarate (Vumerity) work?
• How is it taken?
• How effective are dimethyl fumarate (Tecfidera and generics) and diroximel fumarate (Vumerity)?
• Risks and side effects of dimethyl fumarate (Tecfidera and generics) and diroximel fumarate (Vumerity)
• What is different about diroximel fumarate (Vumerity)?
• Vaccinations
• Sources
• Final note

Sources

I used the following sources to create the content:

• Lecture on dimethyl fumarate (Tecfidera and generics) and diroximel fumarate (Vumerity) by Prof. Mathias Mäurer as part of the Multiple Sclerosis Management master program
• Quality manual of the KKNMS on dimethyl fumarate
• MS-Selfie Infocards by Prof. Dr. Gavin Giovannoni
• German Multiple Sclerosis and Fertility Registry (DMSKW)
• Information from the German interview with Prof. Dr. Barbara Kornek on pediatric MS

Final note

Please remember, there is no one great medication that helps everyone, but it must always be weighed up what suits a particular person best. Other illnesses, personal goals and preferences must also be taken into account. Your neurologist and MS nurse are the right persons to talk to and can make individual recommendations. This article is for information purposes only and does not constitute a recommendation. What helps one person may not help another.

I hope that, together with your neurologist and MS nurse, you will quickly find the right immunotherapy for you. And that you can lead a fulfilled, happy and self-determined life with MS, supported by a healthy lifestyle and a dose of fortune.

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See you soon and try to make the best out of your life, Nele

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