Rituximab in Childhood Lupus: Insights and Safety

Lupus Science and Medicine Podcast

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تمت الإضافة منذ قبل nine عام

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Biscuits & Jam

1
The War and Treaty Are Getting Carried Away 46:55

منذ 23 hours46:55

التشغيل لاحقا

قوائم

إعجاب

احب

46:55

The War and Treaty’s Michael and Tanya Trotter grew up in Cleveland, Ohio, and Washington, DC, respectively, but both have family roots in the South. They also grew up in the musical traditions of their churches – Tanya in the Black Baptist Church and Michael in the Seventh Day Adventist Church – where they learned the power of song to move people. After becoming a father at a very young age, Michael eventually joined the armed forces and served in Iraq and Germany, where he took up songwriting as a way of dealing with his experiences there. Meanwhile Tanya embarked on a singing and acting career after a breakthrough appearance in Sister Act 2 alongside Whoopi Goldberg and Lauryn Hill. Now, after a long and sometimes traumatic journey, Michael and Tanya are married, touring, winning all sorts of awards, and set to release their fifth album together, and their fourth as The War and Treaty. Sid talks to Michael and Tanya about the new record, Plus One , as well as their collaboration with Miranda Lambert, what it was like to record at FAME studios in Muscle Shoals, and how they’re blending country, soul, gospel, and R&B. Learn more about your ad choices. Visit podcastchoices.com/adchoices…

منذ عام واحد 15:12

MP3•منزل الحلقة

Join Dr. Anna Wolska and Dr. Jordan Roberts, a pediatric rheumatologist, as they explore the use of Rituximab in treating childhood-onset systemic lupus erythematosus (SLE). They discuss key factors for healthcare providers when prescribing Rituximab to children and adolescents, especially for severe cases like lupus nephritis and CNS involvement. Dr. Roberts presents recent research on Rituximab’s safety, highlighting increased infection risks and the need for targeted prevention strategies. Tune in for expert insights on the latest advancements, challenges, and future directions in pediatric lupus treatment.

Read the paper published in LSM - https://doi.org/10.1136/lupus-2024-001210

59 حلقات

#Medicine #Science And Medicine #BMJ Group #Fitness

Rituximab in Childhood Lupus: Insights and Safety

Lupus Science and Medicine Podcast

22 subscribers

published منذ عام واحد

MP3•منزل الحلقة

Read the paper published in LSM - https://doi.org/10.1136/lupus-2024-001210

59 حلقات

#Medicine #Science And Medicine #BMJ Group #Fitness

كل الحلقات

1
Validating Claims Algorithms for SLE: Geospatial Insights and Impacts on Health Disparities 13:49

منذ 1 day13:49

13:49

Join Dr. Anna Wolska from the Lupus Foundation of America as she talks with Dr. Jim Oates about his recently published study in Lupus Science & Medicine on validating claims-based algorithms in Medicare data to identify SLE and lupus nephritis. Dr. Oates explains how ICD-10 coding and geospatial analysis (via the Lupus Index) can help pinpoint disparities, guide clinical trial recruitment, and reveal how location affects patient outcomes. The conversation covers the varying sensitivity and specificity of different coding algorithms, potential racial differences, and how overlaying socioeconomic and environmental data can shed light on lupus prevalence and improve healthcare resource allocation. Read the article published in LSM - https://doi.org/10.1136/lupus-2024-001329…

1
Rethinking Lupus Nephritis Treatment: Voclosporin vs. High-Dose Steroids 45:40

منذ 30 يومًا45:40

45:40

Early reduction in proteinuria is a key predictor of improved long-term kidney health in lupus nephritis (LN). In this episode, Dr. Anna Wolska from the Lupus Foundation of America speaks with Drs. Maria Dall'Era and Anca Askanase about a new propensity analysis comparing voclosporin-based triple immunosuppressive therapy to traditional high-dose glucocorticoid regimens. They discuss findings from the AURA-LV and AURORA 1 studies, highlighting the safety benefits and earlier proteinuria reduction seen with voclosporin. Tune in to explore how these insights may shape LN treatment guidelines and improve patient outcomes. Read the paper published in LSM: https://doi.org/10.1136/lupus-2024-001319…

1
Rituximab in Childhood Lupus: Insights and Safety 15:12

منذ 8 weeks15:12

15:12

1
Managing Pregnancy in Lupus: Contraception Use and Beyond 25:51

منذ 21 weeks25:51

25:51

In this episode of the Lupus Science and Medicine podcast, Dr. Megan Clowse, a rheumatologist at Duke University, discusses her research on contraceptive practices in women with lupus. Drawing from the RISE Registry, Dr. Clowse explores the alignment of contraception use with 2020 ACR guidelines, uncovering gaps in documentation and prescription practices. The conversation highlights the importance of reproductive health planning, the various birth control options for women with lupus, and the need for improved patient-doctor communication to ensure safe and effective family planning. Tune in to learn more about the findings and their implications for clinical care. Read the related paper published in LSM: https://doi.org/10.1136/lupus-2024-001192…

1
Leveraging Positive Psychosocial Factors to Manage Stress in Lupus 24:06

منذ 26 weeks24:06

24:06

Join host Dr. Anna Wolska as she explores a new study in Lupus Science & Medicine on how positive psychosocial factors—such as resilience, self-efficacy, and emotional support—can reduce stress in people with systemic lupus erythematosus (SLE). In this episode, she speaks with Drs. Kimberly DeQuattro and Sarah Patterson about these factors' protective effects, even for those with trauma histories, and discusses the study's implications for patient care and how enhancing these factors can improve outcomes in lupus management. Read the paper published in LSM: https://doi.org/10.1136/lupus-2023-001060…

1
Krill Oil may represent a promising complementary therapy in SLE 24:24

منذ 30 weeks24:24

24:24

Join Dr. Anna Wloska from the Lupus foundation of America and Drs. Peter Lipsky and Amerie Grammer as they discuss the effectivenss of krill oil in reducing disease activity in systemic lupus erythematosus. In this episode, our guest highlight the potential therapeutic benefits of restoring omega-3 fatty acids in patients with SLE and the potency and efficacy of omegga-3s found in krill oil versus other sources. Read the paper published in LSM - https://doi.org/10.1136/lupus-2024-001201…

1
Understanding the Critical Role of Lupus Clinical Trial Outcome Measures in Advancing Therapeutic Development 19:43

منذ 35 weeks19:43

19:43

Join Dr. Anna Wolska from the Lupus Foundation of America and Dr. Laurent Arnaud, Professor of Rheumatology at the Department of Rheumatology, University Hospitals of Strasbourg as they discuss systemic lupus erythematosus (SLE) clinical trials. In this episode, Dr. Arnaud highlights the complexities of drug approval processes in lupus, the pivotal role of large-scale phase three randomized trials and critical outcome measures in these trials, from primary endpoints assessing treatment efficacy to secondary and exploratory measures capturing broader impacts on patient health and quality of life. Read the article: https://lupus.bmj.com/content/11/1/e001114…

1
Interpreting Hydroxychloroquine Blood Levels in Lupus 20:29

منذ 39 weeks20:29

20:29

Join Dr. Anna Wolska from the Lupus Foundation of America as she delves into a groundbreaking discussion with Dr. Stephen Balevic focused on hydroxychloroquine blood levels and understanding medication adherence in lupus patients. In this episode, Dr. Balevic, a rheumatologist and clinical pharmacologist from Duke University, explains the nuances of interpreting hydroxychloroquine levels, the challenges of ensuring patient adherence, and the implications for clinical practice. Discover the latest insights on optimizing lupus treatment and learn about an innovative algorithm to improve adherence monitoring. Read the related paper: https://doi.org/10.1136/lupus-2023-001090…

1
Use of Artificial Intelligence and Machine Learning in Clinical Practice 11:51

منذ 43 weeks11:51

11:51

Join Dr. Anna Wolska and Dr. May Choi as they explore the role of Artificial Intelligence (AI) and Machine Learning (ML) in guiding diagnostic and care decisions for systemic lupus erythematosus (SLE). Dr. Choi delves into key elements of machine learning and its potential impact on improving outcomes, particularly in underserved populations. She also discusses various types of machine learning, such as deep learning, supervised learning, and unsupervised learning, highlighting their respective contributions to enhancing efficiencies within clinical care settings. Read the related Review published in LSM: https://doi.org/10.1136/lupus-2023-001140…

1
To RNase or Not to RNase: That Is the Question 14:05

منذ 1 year14:05

14:05

Join Dr. Anna Wolska and Dr. Jim Posada as they delve into the intricacies of RNAse therapy in the management of Systemic Lupus Erythematosus (SLE). In this podcast episode, Dr. Posada describes the groundbreaking study evaluating the efficacy of RSLV-132, a novel RNAse molecule fused to human IgG1 Fc, in reducing chronic inflammation associated with cutaneous lupus. Key findings from the clinical trial reveal that patients with moderate to severe cutaneous disease activity were administered RSLV-132 over a span of six months. Disease activity was evaluated using the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) score and Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K). These findings suggest that RNAse therapy may be effective in patients with higher disease activity. Read the related paper in LSM - https://doi.org/10.1136/lupus-2023-001113…

1
A decision-aid facilitates patient understanding of benefits vs. risk of hydroxychloriquine use as part of routine care for lupus 15:05

منذ 1 year15:05

15:05

Dr. Anna Wolska engages in a conversation with Dr. Shivani Garg and Dr. Christie Bartels to delve into the development and implementation of HCQ-SAFE. This innovative decision-aid is designed to empower individuals living with lupus to engage in shared-decision making. The authors discuss the importance of streamlining and enhancing shared decision-making dynamics between patients and healthcare providers regarding the utilization of hydroxychloroquine, a cornerstone therapy in lupus. The tool can be accessed through the following link: http://hcqsafe.medicine.wisc.edu/ Read the article: https://doi.org/10.1136/lupus-2023-000935…

1
Dual dsDNA testing may be needed to fully understand patient disease status 21:40

منذ 1 year21:40

21:40

Dr. Anna Wolska speaks to Dr. Michael Belmont and Devyn Zaminski to discuss the importance of dual dsDNA testing in order to full understand disease activity. In this study, they made the observation that there is a large amount of discordance in anti-dsDNA antibodies assays. Misinterpretation or errors in anti- dsDNA antibody testing could have negative implications on long term outcomes in people living with SLE. Read the related paper - https://doi.org/10.1136/lupus-2023-001012…

1
Is Anifrolumab an effective treatment for lupus nephritis? 12:44

منذ 1 year12:44

12:44

Dr. Anna Wolska engages in a discussion with renowned experts, Dr. Catharina Lindholm and Dr. David Jayne, to explore findings from the phase II TULIP Lupus Nephritis trial. This in-depth conversation centers on results from a clinical trial where they evaluated the efficacy of intensified anifrolumab treatment in individuals with active lupus nephritis. Read the article: http://dx.doi.org/10.1136/lupus-2023-000910…

1
Which one is better at controlling lupus: Belimumab or Anifrolumab? 12:38

منذ 1 year12:38

12:38

Dr. Anna Wolska sits down with experts, Dr. Michelle Petri and Dr. Nick Ballew, analyzing the effectiveness of SLE treatments Belimumab and Anifrolumab. The conversation delves into their meticulous study, where they examined the 52-week SLE Responder Index (SRI)-4 responses, providing crucial data for informed lupus patient care. The study data, based on rigorous randomized trials and systematic literature reviews, offers clinicians invaluable insights into treatment decisions for people living with lupus. Read the published article: http://dx.doi.org/10.1136/lupus-2023-000907…

1
Managing Lupus Nephritis: Importance of Immunosuppression and Mitigation of Tissue Fibrosis 23:27

منذ 1 year23:27

23:27

Dr. Anna Wolska from the Lupus Foundation of America interviews Drs. Ana Malvar and Brad Rovin. They discuss using repeat tissue biopsies to understand progression of lupus nephritis over time. They offer conjecture that both immunosuppression as well as mitigation of tissue fibrosis, resulting from inflammatory resolution, are needed in order to preserve kidney function and prevent progression to kidney failure. Read the related article - http://dx.doi.org/10.1136/lupus-2023-000932…

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Rituximab in Childhood Lupus: Insights and Safety

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Rituximab in Childhood Lupus: Insights and Safety