Inflammation And Cardio-Rheumatology With Dr Nehal Mehta Future Pulse Cardiology podcast

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This Is Woman's Work with Nicole Kalil

1
QUALIFIED: How Competency Checking and Race Collide at Work with Shari Dunn | 284 33:58

منذ 10 أيام33:58

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33:58

In this episode, we delve into the concept of being "qualified" in the workplace, examining who gets labeled as such, who doesn't, and the underlying reasons. We explore "competency checking"—the practice of scrutinizing individuals' abilities—and how it disproportionately affects underrepresented groups, often going unnoticed or unchallenged. Our discussion aims to redefine qualifications in a fair, equitable, and actionable manner. Our guest, Shari Dunn , is an accomplished journalist, former attorney, news anchor, CEO, university professor, and sought-after speaker. She has been recognized as Executive of the Year and a Woman of Influence, with her work appearing in Fortune Magazine, The Wall Street Journal, Ad Age, and more. Her new book, Qualified: How Competency Checking and Race Collide at Work , unpacks what it truly means to be deserving and capable—and why systemic barriers, not personal deficits, are often the real problem. Her insights challenge the narratives that hold so many of us back and offer practical solutions for building a more equitable future. Together, we can build workplaces and communities that don’t just reflect the world we live in, but the one we want to create. A world where being qualified is about recognizing the talent and potential that’s been overlooked for far too long. It’s not just about getting a seat at the table—it’s about building an entirely new table, one designed with space for all of us. Connect with Our Guest Shari Dunn Website& Book - Qualified: https://thesharidunn.com LI: https://www.linkedin.com/today/author/sharidunn TikTok: https://www.tiktok.com/@thesharidunn Related Podcast Episodes: How To Build Emotionally Mature Leaders with Dr. Christie Smith | 272 Holding It Together: Women As America's Safety Net with Jessica Calarco | 215 How To Defy Expectations with Dr. Sunita Sah | 271 Share the Love: If you found this episode insightful, please share it with a friend, tag us on social media, and leave a review on your favorite podcast platform! 🔗 Subscribe & Review: Apple Podcasts | Spotify | Amazon Music…

Future Pulse Cardiology »
Inflammation and Cardio-Rheumatology with Dr Nehal Mehta

منذ عام واحد 52:03

MP3•منزل الحلقة

We would love to hear your thoughts on the episodes!

Dr Thomas Nero discusses inflammation and the role of rheumatologic disorders on coronary artery disease with Dr Nehal Mehta, exploring how chronic inflammation serves as a cornerstone for various health issues, particularly in patients with conditions like psoriasis and serves as a model for investigating cardiovascular therapies. The discussion highlights the role of immune responses, the impact of lifestyle factors, and the importance of early diagnosis and risk assessment in managing cardiovascular health.
Early Research

Dr Mehta's research began by observing obese patients with heart attacks despite few cardiovascular risk factors.
He found adipose inflammation was driving obesity and insulin resistance.
Psoriasis became a model for studying chronic inflammation's effects on cardiovascular health.

Inflammation and Cardiovascular Disease

Atherosclerosis requires both injury and lipids.
Endothelial damage initiates inflammation in atherosclerosis.
Neutrophils and myeloid cells play a critical role in the inflammatory process.
Different inflammatory diseases have distinct cytokine profiles (e.g., psoriasis vs. lupus).

Adipose Tissue and Inflammation

Visceral fat is metabolically active and a key site of inflammation.
Psoriatic flares increase visceral fat volume and adipose tissue macrophages.
Obese psoriasis patients have higher risks of cardiovascular events.

Coronary Artery Disease in Inflammatory Conditions

Coronary inflammation can be detected by perivascular fat attenuation index (pFAI).
Untreated psoriasis patients show progression from inflammation to plaque formation.
Coronary artery calcium (CAC) scoring may underestimate disease in younger patients.

Diagnostic Approaches

Dr. Mehta recommends assessing blood pressure, body mass index, lipids, and glucose.
Neutrophil-lymphocyte ratio (NLR) and GlycA are useful inflammatory markers.
Imaging like carotid intima-media thickness and pFAI can help identify early vascular disease.

Treatment Strategies

Early statin initiation is recommended for psoriasis patients.
Ongoing trials are exploring various anti-inflammatory agents (e.g., colchicine, IL-6 inhibitors).
Future therapies may include oral IL-23 inhibitors and weight loss medications.

Future Research Directions

Retinal arteries as a model for studying vascular disease and lipid deposition.
Exploring lipid accumulation in various tissues, including the central nervous system.
Developing therapies to address lipid-driven processes in diseases of aging.

The discussion emphasizes the complex interplay between inflammation, lipid metabolism, and cardiovascular disease, highlighting the need for personalized approaches and continued research in this field.

22 حلقات

#Science #Fitness #Biology #Entrepreneur #Business #Medicine #Thomas Nero MD FACC #Cardiology #Atrial Fibrillation #John Mandrola #Clinical Trials

Future Pulse Cardiology

Inflammation and Cardio-Rheumatology with Dr Nehal Mehta

Future Pulse Cardiology

published منذ عام واحد

MP3•منزل الحلقة

We would love to hear your thoughts on the episodes!

Dr Mehta's research began by observing obese patients with heart attacks despite few cardiovascular risk factors.
He found adipose inflammation was driving obesity and insulin resistance.
Psoriasis became a model for studying chronic inflammation's effects on cardiovascular health.

Inflammation and Cardiovascular Disease

Atherosclerosis requires both injury and lipids.
Endothelial damage initiates inflammation in atherosclerosis.
Neutrophils and myeloid cells play a critical role in the inflammatory process.
Different inflammatory diseases have distinct cytokine profiles (e.g., psoriasis vs. lupus).

Adipose Tissue and Inflammation

Visceral fat is metabolically active and a key site of inflammation.
Psoriatic flares increase visceral fat volume and adipose tissue macrophages.
Obese psoriasis patients have higher risks of cardiovascular events.

Coronary Artery Disease in Inflammatory Conditions

Coronary inflammation can be detected by perivascular fat attenuation index (pFAI).
Untreated psoriasis patients show progression from inflammation to plaque formation.
Coronary artery calcium (CAC) scoring may underestimate disease in younger patients.

Diagnostic Approaches

Dr. Mehta recommends assessing blood pressure, body mass index, lipids, and glucose.
Neutrophil-lymphocyte ratio (NLR) and GlycA are useful inflammatory markers.
Imaging like carotid intima-media thickness and pFAI can help identify early vascular disease.

Treatment Strategies

Early statin initiation is recommended for psoriasis patients.
Ongoing trials are exploring various anti-inflammatory agents (e.g., colchicine, IL-6 inhibitors).
Future therapies may include oral IL-23 inhibitors and weight loss medications.

Future Research Directions

Retinal arteries as a model for studying vascular disease and lipid deposition.
Exploring lipid accumulation in various tissues, including the central nervous system.
Developing therapies to address lipid-driven processes in diseases of aging.

22 حلقات

#Science #Fitness #Biology #Entrepreneur #Business #Medicine #Thomas Nero MD FACC #Cardiology #Atrial Fibrillation #John Mandrola #Clinical Trials

كل الحلقات

Future Pulse Cardiology

1
Inflammation and Cardio-Rheumatology with Dr Nehal Mehta 52:03

منذ 10 weeks52:03

52:03

We would love to hear your thoughts on the episodes! Dr Thomas Nero discusses inflammation and the role of rheumatologic disorders on coronary artery disease with Dr Nehal Mehta, exploring how chronic inflammation serves as a cornerstone for various health issues, particularly in patients with conditions like psoriasis and serves as a model for investigating cardiovascular therapies. The discussion highlights the role of immune responses, the impact of lifestyle factors, and the importance of early diagnosis and risk assessment in managing cardiovascular health. Early Research Dr Mehta's research began by observing obese patients with heart attacks despite few cardiovascular risk factors. He found adipose inflammation was driving obesity and insulin resistance. Psoriasis became a model for studying chronic inflammation's effects on cardiovascular health. Inflammation and Cardiovascular Disease Atherosclerosis requires both injury and lipids. Endothelial damage initiates inflammation in atherosclerosis. Neutrophils and myeloid cells play a critical role in the inflammatory process. Different inflammatory diseases have distinct cytokine profiles (e.g., psoriasis vs. lupus). Adipose Tissue and Inflammation Visceral fat is metabolically active and a key site of inflammation. Psoriatic flares increase visceral fat volume and adipose tissue macrophages. Obese psoriasis patients have higher risks of cardiovascular events. Coronary Artery Disease in Inflammatory Conditions Coronary inflammation can be detected by perivascular fat attenuation index (pFAI). Untreated psoriasis patients show progression from inflammation to plaque formation. Coronary artery calcium (CAC) scoring may underestimate disease in younger patients. Diagnostic Approaches Dr. Mehta recommends assessing blood pressure, body mass index, lipids, and glucose. Neutrophil-lymphocyte ratio (NLR) and GlycA are useful inflammatory markers. Imaging like carotid intima-media thickness and pFAI can help identify early vascular disease. Treatment Strategies Early statin initiation is recommended for psoriasis patients. Ongoing trials are exploring various anti-inflammatory agents (e.g., colchicine, IL-6 inhibitors). Future therapies may include oral IL-23 inhibitors and weight loss medications. Future Research Directions Retinal arteries as a model for studying vascular disease and lipid deposition. Exploring lipid accumulation in various tissues, including the central nervous system. Developing therapies to address lipid-driven processes in diseases of aging. The discussion emphasizes the complex interplay between inflammation, lipid metabolism, and cardiovascular disease, highlighting the need for personalized approaches and continued research in this field.…

Future Pulse Cardiology

1
Coronary Inflammation Imaging with FAI Score on CT angiography with Prof. Stefan Neubauer 45:30

منذ 37 weeks45:30

45:30

We would love to hear your thoughts on the episodes! Prof. Stefan Neubauer and Dr. Thomas Nero discuss two recent papers on the utility of coronary inflammation imaging on CT coronary angiography with Fat Attenuation Index (FAI)FAI score. The ORFAN study demonstrated a 20 fold increased risk in CV event rates with low vs high FAI score and a 10 fold increased event rate in patients with elevated FAI score who have no coronary plaque. FAI score re-categorized 40% of patients in their follow-up studies. Prof. Neubauer is the head of the Division of Cardiovascular Medicine and Director of the Oxford Centre for Clinical Magnetic Resonance Research (OCMR) at the University of Oxford and Past President of the Society for Cardiovascular Magnetic Resonance (SCMR). We discussed two recently published landmark papers from his division: Kenneth Chan, Elizabeth Wahome , et al. Inflammatory risk and cardiovascular events in patients without obstructive coronary artery disease: the ORFAN multicentre, longitudinal cohort study. Lancet. 2024;403(10392):1823-1835. doi:10.1016/S0140-6736(24)00596-8 Christopher J. Farina, Michael H. Davidson, Prediman K. Shah, Charles Stark, Wenqi Lu, Cheerag Shirodaria, Timothy Wright, Charalambos A. Antoniades, Jan Nilsson and Nehal N. Mehta (2024). Inhibition of oxidized low-density lipoprotein with orticumab inhibits coronary inflammation and reduces residual inflammatory risk in psoriasis: a pilot randomized, double-blind placebo-controlled trial . Cardiovascular Research, European Society of Cardiology, March 25, 2024.…

Future Pulse Cardiology

1
Trial Statistics, Trial Design and AI with Dr. C Michael Gibson 34:28

منذ 1 year34:28

34:28

We would love to hear your thoughts on the episodes! Dr Gibson and Dr Nero discuss the oft maligned issue of medical statistics. Their discussion covers the pros and cons of traditional Cox proportional hazards regression models and Kaplan-Meier curves and newer techniques including win ratios. They then dip their toes into AI. A great overview by one of our leading clinical trialists.…

Future Pulse Cardiology

1
Deep Dive into Lp(a) with Dr Steven Nissen Part 2 of 2 48:10

منذ 1 year48:10

48:10

We would love to hear your thoughts on the episodes! This episode is a deep dive into Lipoprotein a with Dr Steven Nissen from the Cleveland Clinic. He and Dr Nero discuss the genetics of Lp(a), its pathophysiology, current treatment strategies and research into lowering Lp(a) levels. This is a fascinating conversation that also discusses the role of coronary inflammation in the work of Dr. Paul Ridker as well as the role of CT angiography in future clinical trials.…

Future Pulse Cardiology

1
Lp(a): a basic clinical approach with Dr. Steven Nissen Part 1 of 2 11:00

منذ 1 year11:00

11:00

We would love to hear your thoughts on the episodes! Dr Steven Nissen from the Cleveland Clinic discuses with Dr. Thomas Nero the basic clinical approach to Lp(a) with need for routine testing and a few simple case studies. In the second (longer podcast) they take a deep deep dive into Lp(a) genetic, pathophysiology and the current research trials.…

Future Pulse Cardiology

1
Coronary Artery Disease in the Endurance Athlete with Dr Aaron Baggish 41:40

منذ 1 year41:40

41:40

We would love to hear your thoughts on the episodes! Dr Thomas Nero speaks with Dr Aaron Baggish about coronary artery disease in the endurance athlete (and non-athlete as well!) They discuss cardiovascular testing in Masters athletes including ETT, coronary calcium scoring and CT angiography as well as risk factor identification, inflammation, physical & emotional stress and ongoing research. Dr Baggish is a Professor of Sports Cardiology at Université de Lausanne and founder of the Cardiovascular Performance Program, Massachusetts General Hospital, Harvard Medical School. He has been team cardiologist for USA rowing, US Soccer, and the New England Patriots. He was the medical director for the Boston Marathon and is a consultant to the IADA, IOC and FIFA.…

Future Pulse Cardiology

1
Atrial Fibrillation and Clinical Trials with Dr John Mandrola 48:30

منذ 1 year48:30

48:30

We would love to hear your thoughts on the episodes! Dr Mandrola discusses recent trail data with Dr. Thomas Nero including the results from Artesia, NOAH Afnet 6, Frail AF, Azalea and Oceanic-AF. They also discuss Left Atrial Appendage Occlusion and utility of wearable devices. Finally, a shout out to Dr. Andre Foy and his work on multi-morbidity and its role in clinical trial interpretation.…

Future Pulse Cardiology

1
Coronary Calcium Score and CT Coronary Angiography with Dr. Mathew Budoff 24:35

منذ 1 year24:35

24:35

We would love to hear your thoughts on the episodes! Dr. Thomas Nero speaks with Dr. Mathew Budoff about Coronary Calcium Scoring, CT Coronary Angiography and cardiovascular outcomes. The discussion goes beyond basic risk factor enhancement, highlighting its role to help evaluate disease progression, power future clinical trials and determine efficacy of therapy. Along the way, they discuss coronary inflammation, perivascular adipose tissue imaging and fat attenuation index (FAI) as well as diving into the plaque stabilizing effects of EPA.…

Future Pulse Cardiology

1
Dr Elizabeth Ofili and The African American Heart Study 34:24

منذ 1 year34:24

34:24

We would love to hear your thoughts on the episodes! Dr. Elizabeth Ofili discusses the African American Heart Study with Dr. Thomas Nero. They also discuss her work at the NIH and the African American Heart Failure Trial and the role of community based pragmatic clinical trials.

Future Pulse Cardiology

1
Anticoagulation, Thombin Generation and Factor XI inhibition in ACS and Atrial Fibrillation with Dr C. Michael Gibson 30:16

منذ 2 years30:16

30:16

We would love to hear your thoughts on the episodes! Dr. Thomas Nero discusses current therapy with Factor X inhibitors, the new research with Factor XI inhibition and specifically the enrolling Milvexian clinical trials with Dr. C Micahel Gibson. In addition they discuss, the addition of these medications along wiht anti-platelet therapy, Lp(a) and other interesting current and future research in cardiovascular disease.…

Future Pulse Cardiology

1
Diabetes and Cardiovascular Disease, SGLT2 inhibitors and GLP1 receptor agonists with Dr. Peter Toth 45:58

منذ 2 years45:58

45:58

We would love to hear your thoughts on the episodes! Dr. Thomas Nero speaks with Dr Peter Toth about the dramatic change occuring in diabtetes management and its effect on cardiovascular disease. Starting with the biochemestry of diabetes and its effects at the cellular level, the discussion goes on to speak about the role SGLT2 inhibitors and GLP1 receptor agonists play in DM management as well as the future of diabetes care. (If you want to skip the excelllent, but quite deep dive into biochemistry, jump to 11:22 - but honestly Dr. Toth's description is breathtaking)…

Future Pulse Cardiology

1
Lipids, Lipid Sub-fractionations and Inflammation, Putting It All Together with Dr Peter Toth 34:58

منذ 2 years34:58

34:58

We would love to hear your thoughts on the episodes! Dr. Thomas Nero speaks with Dr. Peter Toth about the complex biology of lipids and atherosclerosis. In this episode Dr Toth dives into LDL goals, therapies for attenuating non-LDL risk, vascular biology and the where are research studies lead us in choosing therapies.…

Future Pulse Cardiology

1
Inflammation and Coronary Artery Disease with Dr Paul Ridker 40:52

منذ 2 years40:52

40:52

We would love to hear your thoughts on the episodes! Dr Paul Ridker discusses his paper on residual inflammatory risk that was recently published in the Lancet with Dr. Thomas Nero. He discusses the pathology of inflammation as part of atherosclerosis, utilization of hs-CRP in clinical trials and in daily practice as well as current therapeutic options and ongoing investigations.…

Future Pulse Cardiology

1
Pragmatic Clinical Trials and EVOLVE-MI with Dr Christopher Cannon 21:01

منذ 2 years21:01

21:01

We would love to hear your thoughts on the episodes! Dr Christopher Cannon discusses the potential of Pragmatic Clinical Trials in our research armamentarium with Dr. Thomas Nero. They review the EVOLVE-MI trial for Early use of Evolocumab after Myocardial Infarction in detail and highlight the potential for future research.…

Future Pulse Cardiology

1
Spontaneous Coronary Artery Dissection (SCAD) with Dr. Sharonne Hayes Part 1 26:13

منذ 3 years26:13

26:13

We would love to hear your thoughts on the episodes! Dr Sharonne Hayes of the May Clinic discusses SCAD with Dr. Thomas Nero. Initially focusing on the new treatment paradigms, their wide ranging discussion covers etiology, pathophysiology and potential future therapeutic options. Tis is the first of a two part podcast.…

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Future Pulse Cardiology » Inflammation and Cardio-Rheumatology with Dr Nehal Mehta

Inflammation and Cardio-Rheumatology with Dr Nehal Mehta

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Inflammation and Cardio-Rheumatology with Dr Nehal Mehta