LATE, Explained

Dementia Matters

While there are many kinds of dementia, like Alzheimer’s disease and Lewy body dementia, there’s one that researchers have only recently identified. LATE, or Limbic-predominant Age-related TDP-43 Encephalopathy, is a newly-characterized type of dementia associated with abnormal clumps of a protein called TDP-43. So, what exactly do we know about LATE? Dr. David Wolk joins the podcast to share what key features of LATE are, how it compares to Alzheimer’s disease and impacts treatment, and what next steps are needed to better understand this neurodegenerative disease.

Guest: David Wolk, MD, director, Penn Alzheimer’s Disease Research Center, co-director, Penn Memory Center, co-director, Penn Institute on Aging, chief, Division of Cognitive Neurology, professor of neurology, University of Pennsylvania Perelman School of Medicine

Show Notes

Learn more about LATE on the National Institute on Aging’s website and on Penn Memory Center’s website.

Read Dr. Wolk's article, "Clinical criteria for limbic-predominant age-related TDP-43 encephalopathy," on the journal Alzheimer's & Dementia's website.

Learn more about Dr. Wolk in his profile on the Penn Memory Center website.

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