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"Got Guts" The Micro Version: Implicating the Cholecystokinin B Receptor in Liver Stem Cell Oncogenesis
Manage episode 424794497 series 3332773
In this episode of "Got Guts" The Micro Version, Jill P. Smith highlights the recently published research titled "Implicating the cholecystokinin B receptor in liver stem cell oncogenesis." This investigation identified a novel pathway involving the activation of hepatic stem cells and liver oncogenesis. Receptor blockade or genetic disruption of the cholecystokinin-B receptor (CCK-BR) signaling pathway decreased the activation and proliferation of hepatic stem cells after liver injury without eliminating the regenerative capacity of healthy hepatocytes.
Article Citation:
Implicating the cholecystokinin B receptor in liver stem cell oncogenesis Martha D. Gay, Jack C. Drda, Wenqiang Chen, Yimeng Huang, Amal A. Yassin, Tetyana Duka, Hongbin Fang, Narayan Shivapurkar, and Jill P. SmithAmerican Journal of Physiology-Gastrointestinal and Liver Physiology 2024 326:3, G291-G309
33 حلقات
"Got Guts" The Micro Version: Implicating the Cholecystokinin B Receptor in Liver Stem Cell Oncogenesis
American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast
Manage episode 424794497 series 3332773
In this episode of "Got Guts" The Micro Version, Jill P. Smith highlights the recently published research titled "Implicating the cholecystokinin B receptor in liver stem cell oncogenesis." This investigation identified a novel pathway involving the activation of hepatic stem cells and liver oncogenesis. Receptor blockade or genetic disruption of the cholecystokinin-B receptor (CCK-BR) signaling pathway decreased the activation and proliferation of hepatic stem cells after liver injury without eliminating the regenerative capacity of healthy hepatocytes.
Article Citation:
Implicating the cholecystokinin B receptor in liver stem cell oncogenesis Martha D. Gay, Jack C. Drda, Wenqiang Chen, Yimeng Huang, Amal A. Yassin, Tetyana Duka, Hongbin Fang, Narayan Shivapurkar, and Jill P. SmithAmerican Journal of Physiology-Gastrointestinal and Liver Physiology 2024 326:3, G291-G309
33 حلقات
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