Neurotech Pub podcast

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تمت الإضافة منذ قبل four أعوام

المحتوى المقدم من Paradromics Inc. يتم تحميل جميع محتويات البودكاست بما في ذلك الحلقات والرسومات وأوصاف البودكاست وتقديمها مباشرة بواسطة Paradromics Inc أو شريك منصة البودكاست الخاص بهم. إذا كنت تعتقد أن شخصًا ما يستخدم عملك المحمي بحقوق الطبع والنشر دون إذنك، فيمكنك اتباع العملية الموضحة هنا https://ar.player.fm/legal.

Curated Questions: Conversations Celebrating the Power of Questions!

1
A Fork, A Precipice, A Decision 24:42

منذ 13 يومًا24:42

التشغيل لاحقا

قوائم

إعجاب

احب

24:42

Episode Notes [01:14] Unexpected Email from Employer [05:49] The Deferred Resignation Program [06:34] Initial Reactions and Concerns [08:01] Evaluating the Offer [08:21] Enhanced Standards of Conduct [08:55] Personal Reflections and Concerns [12:21] Seeking Advice and Making a Decision [13:01] Option One: Do Not Resign [14:56] Option Two: Resign [16:44] Insights from Conversations [21:30] Making The Decision [23:51] Final Thoughts and Gratitude Resources Mentioned Sebastian Junger The Soul of Shame by Curt Thompson Donald Trump Elon Musk Steve Bannon Russell Vought Derek Sivers Sumner Crenshaw Brian Fretwell at Finding Good Chad Littlefield The Thought Leaders Practice by Matt Church Simon Cowell Beauty Pill Producer Ben Ford Questions Asked Is it legitimate, and can it be trusted? How are you feeling? What questions come to your mind? Where does your mind go? Are you seeking safety? Would this have been an adrenaline rush as you raced to send the resignation response? What an "enhanced standard" regarding loyalty and trustworthiness was? What are these new "enhanced standards?" Are they beyond what my Constitutional oath requires? If I don't resign, how bright will the target on my back glow? My leadership has supported all my work, but would termination direction come from higher up the chain of command? What would you recommend if we talked over coffee? What questions would you ask? How would you use listening? How would you use silence? How is this scenario playing out in your mind and body? What is coming to the surface for you? How might that influence what you are about to say to me? What are the chances of my name popping on a list and getting fired? How about the chances of being part of an official Reduction in Force and early retirement? Would the administration make a better offer? What do I know about the pending job market? What did I expect the workplace to be like and did I want to be there as the contractions took place? Will the administration pay me through the end of September or will they renege? Can I sufficiently build the Curated Questions business to transition by 1 October? - Do I have the faith or confidence to step into this future as a sole practitioner and grow Curated Questions into all I envisioned? Was this purpose calling? What would I expect the job market to look like at the end of summer if I hadn't developed the income streams to maintain our lifestyle? What is your recommendation? Did it change from your initial recommendation? Where in your body are you feeling the uncertainty? Are you processing this scenario in parallel with your decision as if you had received the email? What additional questions should I have considered? Who else should I have consulted with? How would you have changed my risk rating? What is the correct length of the pregnant pause before making an important announcement? What processes would you use in my circumstance, and what would be different? What questions are at the top of your list to get to a decision? Who would be the members of your pantheon you would counsel with to gain clarity? Apart from the heady analysis, what other key practices would you include in your journey through a similar situation?…

Neurotech Pub

منزل السلاسل•Feed

Paradromics Founder and CEO Matt Angle hosts an informal salon with some of the most influential figures in neurotechnology.

20 حلقات

Neurotech Pub

12 subscribers

updated منذ عام واحد

منزل السلاسل•Feed

Paradromics Founder and CEO Matt Angle hosts an informal salon with some of the most influential figures in neurotechnology.

20 حلقات

كل الحلقات

Neurotech Pub

1
Engineering Mental Health 50:34

منذ 30 weeks50:34

50:34

This episode features Paradromics CEO Matt Angle in a compelling discussion with Amit Etkin, Founder and CEO of Alto Neuroscience; Maryam Shanechi, Dean's Professor in Electrical and Computer Engineering, Neuroscience, Computer Science, and Biomedical Engineering at USC; and Prasad Shirvalkar, Associate Professor of Neurological Surgery, Neurology and Anesthesia at UC San Francisco. They delve into the intersection of neurotechnology and psychiatry, discussing innovative approaches to treating mental health disorders, the potential of machine learning models, and the challenges associated with obtaining and analyzing brain data. The discussion emphasizes the importance of interdisciplinary collaboration and the promising future of personalized therapies for psychiatric conditions. They also address the limitations of current diagnostic tools like the DSM and the need for scalable, real-world solutions. Guest Quote: “There's artificial intelligence and there's actual intelligence. And that actual intelligence, when it comes to analyzing data, I feel goes a really, really long way. True subject matter expertise.” - Amit Etkin Timestamps: *(00:00) Welcome to Neurotech Pub *(00:45) Icebreaker: Unpopular Beliefs *(05:36) Non-surgical brain activity recording and diagnostics *(13:32) Understanding pain: Subjective reports vs. physical representations *(16:33) Rethinking psychiatry and DSM alignment *(21:07) Determining brain data needs and tool validation *(26:47) The need for explainability in AI algorithms *(35:49) Timescales in mental health interventions *(41:22) Advice for aspiring neurotech researchers *(46:25) Closing Thoughts Want More? Learn about Neurotech Pub on Twitter Follow Paradromics on Twitter, LinkedIn , and Instagram Follow Matt on LinkedIn and Twitter…

Neurotech Pub

1
Where There's Blood, There's Signal 1:48:35

منذ 34 weeks1:48:35

1:48:35

This episode features Paradromics CEO Matt Angle in a compelling discussion with Sumner Norman, Co-founder & CEO at Forest Neurotech; Ryan Field,CEO at Kernel; and Mary Lou Jepsen, Founder and CEO of Openwater. They share their career influences, discuss the challenges of managing interdisciplinary teams, and explore the future of neuroimaging and brain-computer interfaces (BCIs). Delving into ultrasound and optical-based techniques, they highlight the transformative potential of non-invasive methods for diagnosing and treating brain conditions. Furthermore, they addresses regulatory hurdles, the evolution of focused research organizations, and offers valuable advice for early-career researchers on leveraging industry trends and fundamental research to drive technological advancements. Guest Quote: “And I think what we're trying to work on is the silicon hospital of the future with this capability, like the modern smartphone, that can reach everybody, regardless of income levels or borders.” - Mary Lou Jepsen Timestamps: *(00:00) Welcome to Neurotech Pub *(00:06) Meet the Guests *(02:48) Balancing Mentorship and Startup Demands *(05:36) Interdisciplinary Challenges in Neurotech *(07:11) Hardware Development and Efficiency *(18:12) Medical Device Development and Regulatory Challenges *(23:37) Technical Deep Dive: Optical and Acoustic Signatures *(24:00) Ultrasound in Brain-Computer Interfaces *(34:57) Near-Infrared Spectroscopy and Mental Health *(55:55) Understanding Stroke and Thrombectomy *(56:51) Innovations in Cancer Treatment and Blood Flow Analysis *(57:39) Challenges and Trials in Medical Technology *(58:42) Open Source Medical Technology and Global Collaboration *(58:59) The Evolution of Brain-Computer Interfaces *(01:02:42) Advancements in Ultrasound Technology *(01:03:39) The Role of MEMS and Silicon in Medical Devices *(01:09:29) The Importance of Fundamental Research *(01:14:48) The Future of Neurotechnology and Industry Trends *(01:17:58) Advice for Aspiring Researchers and Entrepreneurs *(01:29:41) Leadership and Transition in Tech Companies *(01:40:07) Focused Research Organizations and Their Impact *(01:46:08) Final Thoughts and Optimism for Neurotech Want More? Learn about Neurotech Pub on Twitter Follow Paradromics on Twitter, LinkedIn , and Instagram Follow Matt on LinkedIn and Twitter…

Neurotech Pub

1
Now That’s a Lot of Power 1:13:38

منذ 38 weeks1:13:38

1:13:38

This episode features Paradromics CEO Matt Angle in a compelling discussion with Grayson Zulauf, CEO of Resonant Link; Alex Yeh, CTO and VP of R&D at Neuspera Medical; and Jacob Robinson, Founder and CEO of Motif Neurotech. They explore the latest advancements in neurotechnology, focusing on wireless power transfer, implantable devices, and brain-computer interfaces (BCIs). The conversation highlights transformative innovations in treating mental health conditions like major depressive disorder, OCD, and ADHD with less invasive wireless devices, enhancing patient care and acceptance. Personal stories and insights on market expansion and patient-friendly treatments are shared, along with valuable advice for investors on the potential of neurotechnology in improving overall mental health and medical care. Guest Quote: “The message that I would want to send is, there is a future in which we look at neurotechnologies no differently than we look at cardiac pacemakers. These are life saving devices, in many cases less invasive than a device that goes in your heart. There's no reason why anybody wouldn't want to feel better. To be healthier mentally and just live a better quality of life. So that's what we're trying to enable” - Jacob Robinson Show Notes: *(00:00) Welcome to Neurotech Pub *(00:46) Meet the Guests *(02:45) Discussing Industry Competitors *(09:54) Wireless Power Transfer in Medical Devices *(16:38) Exploring Inductive and Magnetoelectric Power *(27:35) Ultrasound in real-world devices *(33:31) Patient Experience and Device Miniaturization *(36:24) Designing for Patient Comfort and Practicality *(38:20) Innovations in Power and Data Transmission *(39:32) Miniaturization and Its Impact *(41:12) Battery Technology in Medical Devices *(43:19) Future of Implantable Batteries *(45:16) Implanted Battery Companies Integer and Resonetics *(46:31) Intermittent Stimulation and Therapy *(49:28) Power Consumption in Future Implants *(59:52) Data Transmission and Compression *(01:05:42) Reflections on the Journey of Medical Innovation *(01:08:36) Final Thoughts and Messages to Investors Want More? Follow Neurotech Pub on Twitter Follow Paradromics on Twitter, LinkedIn , and Instagram Follow Matt on LinkedIn and Twitter…

Neurotech Pub

1
Your Future Self Will Thank You | Connectomics Part II 1:00:56

منذ 2 years1:00:56

1:00:56

We’re back with Part II of our two-part series on Connectomics! In part one we speculated on the legal and ethical implications of emerging technologies in the connectomics field. In part two, we don our lab coats and take a deep dive into the latest research tools, from fixation protocols for the preservation of neural tissue, to multimodal imaging techniques, to the machine intelligence designed to interpret massive data sets and reconstruct the vast neural circuits that make up the connectome. Our guests are: Kenneth Hayworth, PhD , President and Co-Founder of the Brain Preservation Foundation, Senior Scientist at the Howard Hughes Medical Institute’s Janelia Farm Research Campus (JFRC) Robert McIntyre , CEO at Nectome Jeremy Maitin-Shepard , PhD, Software Engineer–Connectomics at Google In this episode, Ken and Robert from part one return to the pub, and we are also joined by Jeremy Maitin-Shepard, an engineer and researcher at Google, who shares insights into some of the machine intelligence modalities being used to decode previously uncharted neural networks. Check out Jeremy’s recent paper on BioRxiv , as well as his published work at Google. If you missed part one, you can listen and explore the show notes here . Cheers! Show Notes: 0:00 | Intro 1:03 | Kenneth Hayworth, PhD 1:12 | Robert McKintyre, CEO, Nectome 1:17 | Jeremy Maitin-Shepard, PhD 1:51 | Setting the record straight 3:09 | The nucleotide sequence of bacteriophage φX174 4:22 | Frozen Zoo at San Diego Zoo 12:01| Glutaraldehyde and reduction techniques for immunolabeling 17:39 | SWITCH Framework 19:14 | Population Responses in V1 Encode Different Figures by Response Amplitude Enhanced mirror neuron network activity and effective connectivity during live interaction among female subjects Permeabilization-free en bloc immunohistochemistry for correlative microscopy 19:57 | Synaptic Signaling in Learning and Memory Structure and function of a neocortical synapse Engineering a memory with LTD and LTP Synapse-specific representation of the identity of overlapping memory engrams 20:28 | Ultrastructure of Dendritic Spines Structure–stability–function relationships of dendritic spines 24:25 | Reconstructing the connectome 24:32 | Connectomics Research Team at Google 24:55 | Google x HHMI: Releasing the Drosophila Hemibrain Connectome 28:38 | Serial Block-Face Scanning Electron Microscopy 29:22 | Automated Serial Sections to Tape 29:45 | Mapping connections in mouse neocortex 30:59 | A connectome and analysis of the adult Drosophila central brain 32:14 | Expansion Microscopy 34:37 | The future of connectomics 45:13 | Contribution of apical and basal dendrites to orientation encoding in mouse V1 L2/3 pyramidal neurons 49:49 | Mice and rats achieve similar levels of performance in an adaptive decision-making task Want More? Follow Neurotech Pub on Twitter Follow Paradromics on Twitter, LinkedIn , and Instagram Follow Matt on LinkedIn and Twitter…

Neurotech Pub

1
We're in Heated Agreement Over Here | Connectomics Part I 49:05

منذ 2 years49:05

49:05

Welcome back to Neurotech Pub! In this first installment of two episodes on Connectomics, host and Paradromics CEO Matt Angle kicks off a lively discussion on the rapidly accelerating research in the mapping, preservation, and reconstruction of the human connectome. We explore the ethical and legal ramifications of disruptive technology, and some of the unique challenges faced when driving innovation in emerging industries. Our guests are: Nita Faraheny, JD, PhD , Everett Distinguished Professor of Law & Philosophy at Duke Law School, the Founding Director of Duke Science & Society, the Faculty Chair of the Duke MA in Bioethics & Science Policy, and principal investigator of SLAP Lab. Kenneth Hayworth, PhD , President and Co-Founder of the Brain Preservation Foundation, Senior Scientist at the Howard Hughes Medical Institute’s Janelia Farm Research Campus (JFRC) Robert McIntyre , CEO at Nectome As an exciting new development since the recording of this episode, Nita recently published a book, The Battle for Your Brain, which examines many topics in neuroethics, from Connectomics to Brain-Computer Interfaces. It is currently available on Amazon . Keep an eye out for part two in this series, which will take a deep dive into the latest technical and engineering innovations in the connectomics ecosystem. Coming soon! Please be advised that this episode contains a brief discussion of assisted suicide in a medical setting. Show Notes: 0:00 | Episode Intro 1:16 | Nita A. Farahany, JD, PhD 1:21 | Kenneth Hayworth, PhD 1:27 | Robert McKintyre, CEO, Nectome 1:56 | Meeting of the minds 2:53 | Aldehyde-stabilized cryopreservation wins final phase of brain preservation prize 3:56 | The Brain Preservation Foundation 4:09 | Documentary series on the Brain Preservation Foundation 5:21 | Letter of Support for Aldehyde Stabilized Cryopreservation (and ‘next steps’ caveats) 5:51 | Nita's 2018 Neuroethics Ted Talk 5:54 | International Neuroethics Society 6:25 | Connectomics & new paths in neuroscience 8:10 | Allen Institute for Brain Science 8:47 | A connectome and analysis of the adult Drosophila central brain 9:33 | A visual intro to synaptic imaging in connectomics 10:28 | The structure of the nervous system of the nematode Caenorhabditis elegans 11:16 | Mouse Connectome Project at CIC 14:59 | Cryonics controversy 19:00 | Death, taxes, and synapses 20:51 | Uniform Law Commission 21:08 | The Uniform Determination of Death Act 24:25 | Watch Altered Carbon on Netflix 25:49 | Understanding the “Loss of Chance” Doctrine 37:13 | Understanding Physician-Assisted Death, or ‘Death with Dignity’ 40:21 | Euthanasia in the Netherlands 46:01 | Autonomy, Dignity, and Consent to Harm, Rutgers Law Review Want More? Follow Neurotech Pub on Twitter Follow Paradromics on Twitter, LinkedIn , and Instagram Follow Matt on LinkedIn and Twitter…

Neurotech Pub

1
Neuro Mapping & Napping 1:06:11

منذ 3 years1:06:11

1:06:11

Welcome back to Neurotech Pub! In this episode we’re talking about sleep–why we sleep, how sleep works on a neurophysiological level, and some of the emerging sleep technologies that are about to revolutionize this essential neural activity. Our guests are Amy Kruse, PhD, General Partner at Prime Movers Lab, Ram Gurumoorthy, PhD, Founder and CTO of Stimscience & Somnee, and Luis de Lecea, PhD, Professor of Psychiatry and Behavioral Sciences at Stanford University School of Medicine. This episode also features a video introduction to sleep stages by Paradromics Intern Zoe Lalji. This is essential viewing if you’re unfamiliar with the stages of sleep and want to follow along later in the episode. Cheers! Show Notes: 00:00 | Episode intro with Matt Angle and Amy Kruse 1:07 | StimScience in Fast Company 5:05 | Learned Motor Patterns Are Replayed in Human Motor Cortex during Sleep 6:43 | Connect with Prime Movers Lab 7:01 | PML on Medium 7:45 | Introduction to Sleep Stages References: Stages of Sleep Overview REM vs Non-REM Sleep Sleep Walking Benefits of REM Sleep Consequences of low REM sleep Importance of Deep Sleep Check out Zoe’s nonprofit organization, ALS Heroes , and her Ted Talk 12:24 | Pulling all-nighters 12:50 | Amy Kruse, PhD 13:00 | Ram Gurumoorthy, PhD 13:07 | Stimscience, now Somnee 13:30 | Luis de Lecea, PhD 18:26 | Gordon Rule, PhD 18:40 | Knights of the Old Republic II: The Sith Lords (2004) 19:50 | Why do we sleep? 20:26 | Sleep drives metabolite clearance from the adult brain 20:35 | Sleep & DNA Repair 22:13 | Neural Activity can cause DNA damage 23:22 | Jerry Seigal 24:26 | DARPA Sleep Research 24:55 | Fur seals and sleep 25:08 | How do Whales and Dolphins Sleep Without Drowning? 25:54 | Putting Humans in Stasis Is the Best Way of Getting Us to Mars 27:36 | Sleep and Mortality 28:09 | The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices 28:27 | Giulio Tononi, MD, PhD 28:45 | Sleep, Memory, and Plasticity 28:52 | Sleep Cognition and Memory 29:00 | Sleeping up and down the phylogenetic tree 29:05 | Actually...worms do sleep 29:20 | Decoding sleep 29:36 | Fruit flies and their mini sleeps 29:44 | Mapping sleep in the brain 30:35 | Hypocretin-positive neurons 31:17 | Clearly Matt slept through his midterm... again 31:57 | The hypocretins/orexins: integrators of multiple physiological functions 32:05 | Stress-sleep interactions 33:30 | The Science of Narcolepsy 35:08 | Equivalence of sleep deprivation and intoxication | Additional reference 36:21 | Sleep Pressure: Homeostatic Sleep Drive 40:38 | EEG Visualization of electrodermal activity during sleep 44:08 | Circuitry of Sleep Stages 45:00 | Regional slow waves and spindles in human sleep | Local sleep in awake rats 48:00 | Emerging Sleep Technologies 1:00:56 | Hypothalamus and Sleep Want More? Follow Neurotech Pub on Twitter Follow Paradromics on Twitter, LinkedIn , and Instagram Follow Matt on LinkedIn and Twitter…

Neurotech Pub

1
BCI Pioneers Part II 44:19

منذ 3 years44:19

44:19

The Panel: Jan Scheuermann is an author and public speaker, and self-styled “professional lab rat.” She has spoken at DARPA, the Johns Hopkins Applied Physics Laboratory, and the National Convention of the ALS Association about her experience as a BCI trial participant at UPitt. She is the author of a fictional mystery novel, Sharp as a Cucumber, available on Amazon . You can find out more about Jan and book her for public speaking events on her website or connect with her on LinkedIn . Ian Burkhart is the President of the Ian Burkhart Foundation , which provides equipment not typically covered by insurance that improves independence for those with spinal cord injuries. He is also the Vice President of the North American Spinal Cord Injury Consortium , an advocacy organization that brings individuals with lived experience together with researchers to improve research, care, cure, and policy. In addition, Ian consults on medical device development and user interaction. Ian’s latest project is the BCI Pioneers Coalition, a platform to connect BCI users, researchers, industry, and other stakeholder groups to discuss the future of Brain Computer Interfaces. You can visit him on his website or connect with him on LinkedIn , Twitter , and Instagram . Nathan Copeland is a neurotechnology consultant, speaker, and digital artist. He has spoken at numerous conventions around the world about his experiences in the lab and has been featured in many prominent publications including, but not limited to, Wired, MIT Tech Review, NPR, Fortune, and the Atlantic. He is the creator of the first BCI NFTs, available on OpenSea. You can connect with Nathan on Instagram , Twitter, and Linkedin . 00:00 | Intro 0:14 | Neurotech Pub Episode 13: BCI Pioneers Part I 0:47 | Neurotech Pub Episode 10: Business Models in Neurotech 1:30 | BCI & Identity 1:30 | New Yorker - Do Brain Implants Change Your Identity? 2:09 | The Utah Array (Blackrock Neurotech) 16:05 | Learn more about Hector in Part 1 17:14 | Talking Form Factors 18:36 | CerePlex System 22:36 | Support Systems in BCI Adoption 38:35 | Get in Touch 38:54 | The Ian Burkhart Foundation 39:13 | Book Ian as a speaker 39:25 | North American Spinal Cord Injury Consortium (NASCIC) 40:04 | Where to find Ian 40:19 | Contact Nathan 40:25 | Nathan on Instagram , LinkedIn , and Twitter 40:32 | Nathan's NFTs on OpenSea Links to Jan’s lab photos and how to get in touch can be found here Want More? Follow Paradromics on Twitter, LinkedIn , and Instagram Follow Blackrock Neurotech on Twitter , LinkedIn, and Instagram Follow Taryn on LinkedIn , Instagram , and Twitter Follow Matt on LinkedIn and Twitter…

Neurotech Pub

1
BCI Pioneers Part I 49:21

منذ 3 years49:21

49:21

In this very special two part series in collaboration with Blackrock Neurotech , Paradromics CEO Matt Angle and Blackrock Creative Director Taryn Southern co-host a discussion with BCI research pioneers Jan Scheuermann, Ian Burkhart, and Nathan Copeland. In part one, we discuss their personal journeys to becoming BCI pioneers, implant experiences with the Utah Array, their time in the lab, and some of their current projects. Learn more about Jan, Ian, and Nathan below and stay tuned for part two, coming in July 2022! The Panel: Jan Scheuermann is an author and public speaker, and self-styled “professional lab rat.” She has spoken at DARPA, the Johns Hopkins Applied Physics Laboratory, and the National Convention of the ALS Association about her experience as a BCI trial participant at UPitt. She is the author of a fictional mystery novel, Sharp as a Cucumber, available on Amazon . You can find out more about Jan and book her for public speaking events on her website or connect with her on LinkedIn . Ian Burkhart is the President of the Ian Burkhart Foundation , which provides equipment not typically covered by insurance that improves independence for those with spinal cord injuries. He is also the Vice President of the North American Spinal Cord Injury Consortium , an advocacy organization that brings individuals with lived experience together with researchers to improve research, care, cure, and policy. In addition, Ian consults on medical device development and user interaction. Ian’s latest project is the BCI Pioneers Coalition, a platform to connect BCI users, researchers, industry, and other stakeholder groups to discuss the future of Brain Computer Interfaces. You can visit him on his website or connect with him on LinkedIn , Twitter , and Instagram . Nathan Copeland is a neurotechnology consultant, speaker, and digital artist. He has spoken at numerous conventions around the world about his experiences in the lab and has been featured in many prominent publications including, but not limited to, Wired, MIT Tech Review, NPR, Fortune, and the Atlantic. He is the creator of the first BCI NFTs, available on OpenSea. You can connect with Nathan on Instagram , Twitter, and Linkedin . 00:00 | Intro 6:10 | Who came first? 7:07 | Jan Scheuermann 7:18 | Tim Hemmes & the UPitt/UPMC Team 8:05 | New Yorker profile of Jan and the UPitt team 8:55 | View Jan’s photos from the lab 10:10 | Nathan Copeland 13:00 | Parietal Cortex 13:22 | Saccade Movements 14:12 | The Pioneer Experience 16:04 | Neuro Life Study | Additional Reference | Interview with Ian | Archives of PMR 18:15 | Mirror Therapy 23:50 | Jan in the Pilot Seat 25:07 | Ian's Experience in the Car Simulator 25:53| Thinking About Thinking 31:24 | Jan's novel, Sharp as a Cucumber 37:37 | View Jan’s photos from the lab 38:04 | Andy Schwartz 38:45 | Nathan's NFTs 43:22 | Nathan's Instagram 45:03 | 15 Minutes of Fame 45:12 | A Presidential Greeting 45:45 | Jan on 60 Minutes 45:54 | Jan in SciAM 46:00 | Book Jan as a keynote speaker 46:32 | SfN 47:05 | Investment in BCI 47:17 | The Ian Burkhart Foundation Want More? Follow Paradromics on Twitter, LinkedIn , and Instagram Follow Blackrock Neurotech on Twitter , LinkedIn, and Instagram Follow Taryn on LinkedIn , Instagram , and Twitter Follow Matt on LinkedIn and Twitter…

Neurotech Pub

1
Mind Control with Lasers: Optical Recording Part II 1:43:44

منذ 3 years1:43:44

1:43:44

Welcome back to Neurotech Pub! This episode is part two of a two part series on optical methods for recording and stimulating neural activity. Our guests on this episode are Elizabeth Hillman, PhD , Mark Schnitzer, PhD , and Jacob Robinson, PhD . Last time we talked about optical recording methods, but in this episode we focus on optical stimulation methods. Cheers! Check out video and full transcript here: https://www.paradromics.com/podcast/episode-12-mind-control-with-lasers 00:00 | Intro 1:37 | Aspirational Papers 1:56 | Packer Lab 2:10 | What is the claustrum? 2:30 | Ian's paper (but only part of it!) 3:02 | Two-Photon Bidirectional Control and Imaging In Vivo 3:29 | Inferring Spikes from Calcium Imaging 5:45 | Neuropixels are now in humans 7:12 | Paper by Pachitariu et al 7:55 | Ian Oldenburg 10:02 | Kaufman Lab 11:21 | Cortical activity in the null space: permitting preparation without movement 12:08 | Motor cortical dynamics shaped by multiple distinct subspaces during naturalistic behavior 12:33 | Tickling Cells with Light 14:41 | Light-activated ion channels for remote control of neuronal firing 14:50 | Remote Control of Behavior through Genetically Targeted Photostimulation of Neurons 15:20 | Millisecond-timescale, genetically targeted optical control of neural activity 16:03 | Red-shifted Opsins 16:52 | eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications 17:26 | Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor 18:16 | Neural Dust 18:41 | Wireless magnetothermal deep brain stimulation 19:05 | Neural Stimulation Through Ultrasound 19:20 | Methods and Modalities: Sculpting Light 21:35 | Recent advances in patterned photostimulation for optogenetics 22:50 | Two-photon microscopy is now over 30 years old (Denk 1990) 25:22 | Optical Recording State of the Art 27:06 | Challenges of Deep Tissue 2-Photon Imaging 28:21 | Deisseroth Lab 28:29 | Temporal Precision of Optical Stimulation 29:09 | Simultaneous all-optical manipulation and recording 30:40 | Targeted Ablation in Somatosensory Cortex 33:29 | Commercially Available Fast Opsins 34:41 | Recent paper from Deisseroth Lab 41:17 | Cortical layer–specific critical dynamics triggering perception 42:21 | The Utah Array from Blackrock Neurotech 44:52 | Principles of Corticocortical Communication 50:43 | The Cost of Cortical Computation 51:27 | Behaviour-dependent recruitment of long-range projection neurons in somatosensory cortex (2013) | Spatiotemporal convergence and divergence in the rat S1 "barrel" cortex (1987) | Diverse tuning underlies sparse activity in layer 2/3 vibrissal cortex of awake mice (2019) 52:56 | Gollisch and Meister 2008 53:22 | Spike Timing-Dependent Plasticity (STDP) 1:05:09 | Neurotech Pub Episode 11 - Let There Be Light 1:05:20 | Forecasting the Future 1:05:41 | Temporally precise single-cell-resolution optogenetics 1:06:16 | Large Scale Ca++ Recordings from Vaziri Lab 1:07:11 | Cohen Lab 1:07:19 | All Optical Electrophysiology 1:14:19 | Emiliani et al 2015 1:16:33 | All-Optical Interrogation of Neural Circuits 1:16:53 | Mice Strains @ Jackson Lab 1:17:00 | The Allen Institute 1:20:39 | Neuroscience and Engineering Collaborations 1:18:39 | Nicolas Pegard 1:18:47 | Adesnik Lab 1:24:41 | S henoy, Sahani, and Churchland 2013 1:24:52 | Dimensionality reduction for large-scale neural recordings 1:25:17 | Matlab: Understanding Kalman Filters 1:25:58 | Two-photon excitation microscopy 1:26:37 | Emiliani Lab Holography course 1:26:57 | Optics by Eugene Hecht 1:28:05 | Intro to Optics Course 1:29:41 | What the Heck Is a Claustrum? 1:33:53 | Cortical activity in the null space: permitting preparation without movement 1:34:33 | Neural Manifolds and Learning 1:35:19 | Locked-in Syndrome 1:36:58 | Sabatini Lab 1:37:07 | Probing and regulating dysfunctional circuits using DBS 1:39:36 | Sliman Bensmaia | Nicho Hatsopoulos 1:39:43 | The science and engineering behind sensitized brain-controlled bionic hands 1:41:20 | Michael Long's singing rodents 1:42:12 | Engram 1:43:06 | Chang Lab 1:43:19 | Tim Gardner | Michale Fee Want more? Follow Paradromics & Neurotech Pub on Twitter Follow Matt A , Ian , Adam , & Matt K on Twitter…

Neurotech Pub

1
Let there be Light: Optical Recording Part I 1:29:09

منذ 3 years1:29:09

1:29:09

Welcome back to Neurotech Pub! This episode is one of a two part series on optical methods for recording and stimulating neural activity. Our guests on this episode are Elizabeth Hillman, PhD , Mark Schnitzer, PhD , and Jacob Robinson, PhD . So far, our technical dives have focused mainly on direct electrical recording and stimulation of neural activity, but in this episode we deep dive into advantages that all-optical interfaces might have over electrical interfaces, and the challenges in developing them. In addition, we talk about running highly collaborative, interdisciplinary projects that span traditional physics and engineering with biology, a theme that is ever-present in neurotech and is also highlighted in part two of this series. Cheers! Check out full video with transcript here: https://www.paradromics.com/podcast/episode-11-let-there-be-light Show Notes Latest news & publications since recording: >> Hillman Lab: New publication on SCAPE in Nature Biomedical Engineering >> Robinson Lab: Review article in Optica on Recent advances in lensless imaging >> Robinson Lab: BioRxiv pre-print on in vivo fluorescence imaging 1:23 | The Heart and Soul of a Paper 2:32| Ultrasmall Mode Volumes in Dielectric Optical Microcavities 3:01 | Robinson Lab 4:01 | Hillman Lab 4:07 | Zuckerman Institute 4:15 | Schnitzer Lab 4:25 | Howard Hughes Medical Institute 4:41| Miniature Fluorescence Microscope 9:02 | Discovery of DNA Structure and Function 10:25 | Hodgkin–Huxley Equations 13:49 | Vessel Dilation in the Brain 16:03 | State of the art of Neural Optical Recording 18:03 | Long-Term Optical Access to an Estimated One Million Neurons in Mouse Cortex 24:56 | Watch the Crystal Skull video 27:45 | High-Speed Cellular-Resolution Light Beads Microscopy 29:54 | Relationship between spiking activity and calcium imaging 32:50 | Analytical & Quantitative Light Microscopy [AQLM] 32:59 | Imaging Structure & Function in the Nervous System 35:22 | NIH Brain Initiative Cell Census Network (BICCN) 35:54 | Allen Brain Atlas: Cell Types 40:17 | A Theory of Multineuronal Dimensionality, Dynamics and Measurement 46:19 | Dr. Laura Waller's DIY Diffuser Cam 50:38 | FlatCam by Robinson Lab 53:42 | Advantages of MEG 55:06| Random Access Two Photon Scanning Techniques 56:07 | Swept Confocally-Aligned Planar Excitation (SCAPE) 58:47 | Optics Systems for Implantable BCIs 1:00:43 | GCaMP - Janelia GECI reagents 1:01:33 | DARPA NESD Program 1:04:06 | SCAPE Microscopy for High-Speed Volumetric Imaging of Behaving Organisms 1:07:00 | Glial Response to Implanted Electrodes 1:07:07 | Brain Tissue Responses to Neural Implants 1:09:36 | Two Deaths in Gene Therapy Trial for Rare Muscle Disease 1:10:46 | Intrinsic Optical Signal due to Blood Oxygenation 1:11:11 | Coupling Mechanism and Significance of the BOLD Signal 1:12:10 | DARPA invests in Treating Mood Disorders 1:12:57 | Amygdalar Representations of Pain 1:13:48 | Fast Optical Signals: Principles, Methods, and Experimental Results 1:14:12 | Dr. Larry Cohen's early work in Neurophotonics 1:14:42 | Linear Systems Analysis of Functional Magnetic Resonance Imaging | Additional Resource 1:16:20 | Flavoprotein Fluorescence Imaging in Neonates | Additional Resource 1:18:02 | Pumped Probe Microscopy 1:19:26 | Biological Imaging of Chemical Bonds by Stimulated Raman Scattering Microscopy 1:19:36 | Coherent Anti-Stokes Raman Scattering microscopy (CARS) 1:19:55 | Min Lab @ Columbia 1:20:06 | Glucose Analog for Stimulated Raman Scattering 1:20:39 | Emerging Paradigms for Aspiring Neurotechnologists Want more? Follow Paradromics & Neurotech Pub on Twitter Follow Matt , Elizabeth , Jacob & Mark…

Neurotech Pub

1
Business Models in Neurotech 1:45:42

منذ 3 years1:45:42

1:45:42

Welcome back to the Season 2 premiere of Neurotech Pub! In this episode, host and Paradromics CEO Matt Angle sits down with fellow Founder/CEOs Carolina Aguilar , Brian Pepin , and Kunal Ghosh to talk shop about building cutting edge neurotech companies from the ground up. We dive deep into business strategies, the neurotech fundraising landscape, emerging therapeutics, and more. We also provide an insider’s view of the intersections of data, pharma, and med devices that are shaping the future of healthcare. Pour yourself a cold one and settle in! Check out full video with transcript here: Check out video and a full episode transcript here. 00:00 | Updates & News >> INBRAIN Neuroelectronics raised a $17M Series A >> Rune Labs raised a $22.8 Million Series A >> Inscopix Launched Cloud-Based Platform for Data Management and Analysis 2:15 | Meet the panel and pick up a book 1:54 | Jester King Brewery 2:25 | Rune Labs 2:50 | Neurostimulator for deep brain stimulation therapy 3:23 | INBRAIN Neuroelectronics 4:11 | Inscopix 5:24 | Ursula K. Le Guin’s 'The Dispossessed' 6:19 | Yuval Noah Harari’s 'Sapiens: A Brief History of Humankind' 6:32 | Daniel G. Miller’s 'The Tree of Knowledge' 6:40 | Jiddu Krishnamurti’s 'The Book of Life' 7:34 | Barack Obama’s 'A Promised Land,' ‘Dreams from my Father,’ & ‘The Audacity of Hope’ 7:56 | Karl Popper’s 'The Open Society and Its Enemies' 9:25 | Venture Capital in Neurotech 34:44 | Business Strategy in Neurotech 40:32 | Tom Oxley, CEO, Synchron 43:58 | Dr. Thomas Insel 44:06 | Mindstrong Mental Health Care 44:35 | Aduhelm controversy 52:25 | Galvani Bio 59:39 | Percept Neurostimulator 1:00:32 | Neuromodulation and the future of treating brain disease 1:07:21 | Software as a Medical Device FDA Guidance 1:09:12 | State of Animal Model Systems 1:14:28 | α-Synuclein in Parkinson's Disease 1:18:01 | Alto Neuroscience 1:18:36 | Flatiron Foundation 1:18:45 | Gaurdent Health 1:19:03 | Melanoma Trends & Rates 1:21:41 | The Pharma-Data-Device Ecosystem 1:21:42 | Frank Fischer, Chairman of Neuropace 1:22:28 | Neurotech Pub Season 1, Episode 9 1:26:35 | Roche acquisition of Flatiron Health & merger with Foundation Medicine 1:27:12 | Companion Diagnostics 1:28:29 | Adhulem and PET imaging 1:29:09 | Resignations at the FDA over Alzheimer’s Drug 1:29:32 | Derek Lowe’s take on the Aducanumab Approval, FDA Committee Votes , Halting the Aducanumab Trials , & The FDA Advisory Committee Briefing Document on Aducanumab 1:31:39 | Donanemab receives breakthrough therapy designation in 2021 1:36:58 | Mapping the Frontal-Vagal Pathwa y 1:37:09 | The Human Connectome Project 1:40:07 | Teal Organizations and Holacracy 1:41:18 | Society for Neuroscience 1:44:37 | Affymetrix (Thermo Fisher Scientific) 1:44:39 | Illumina Want more? Follow Paradromics & Neurotech Pub on Twitter Follow Matt , Brian , Carolina , & Kunal on Twitter…

Neurotech Pub

1
Building (and Funding) Neurotech Companies 1:29:07

منذ 4 years1:29:07

1:29:07

Welcome to the Season 1 finale of Neurotech Pub! In this episode, host and Paradromics CEO, Matt Angle, speaks with fellow Neurotech CEOs, Konstantinos Alataris, Frank Fischer, and Marcus Gerhardt. "We cover a lot in this discussion, but one of the big themes is how challenging it can be to raise money, to build neuro devices. This episode was originally recorded last winter, and it was instantly one of my favorite episodes. So like a fine wine, I laid it down until the time was right to share it with friends. Since the episode was recorded, Nesos, Paradromics, and BlackRock all had major funding announcements. Nesos and BlackRock underwent rebranding campaigns, and NeuroPace went public on Nasdaq. This podcast was recorded during a bleak winter, but our optimism proved prescient. The podcast aged well, and now the field is the strongest, best funded, and most exciting that it's ever been. I know you'll enjoy the discussion." - Matt Angle, CEO, Paradromics Check out full video with transcript here: https://www.paradromics.com/podcast/neurotech-pub-episode-9-building-and-funding-neurotech-companies 01:08 | Meeting Heros 08:02 | Company Origins: NeuroPace, Blackrock Neuro, and Nēsos 25:28 | Now vs Then, a Decade of Neurotech Entrepreneurship 1:04:50 | Investor Backing in Neurotech 1:20:44 | BCI Future Is Underway Want more? Follow Paradromics & Neurotech Pub on Twitter Follow Matt A , and Blackrock Neurotech on Twitter…

Neurotech Pub

1
The Drinks Bring Back All The Memories 1:44:40

منذ 4 years1:44:40

1:44:40

Welcome back to Neurotech Pub! In this episode, host and Paradromics CEO, Matt Angle, brings together memory-researchers Nanthia Suthana (Assist. Prof. of Neurosurgery and Bioengineering, UCLA School of Medicine) and Gyorgy Buzsaki (Biggs Professor of Neuroscience, NYU School of Medicine), and scientist-entrepreneurs Dan Rizzuto (CEO of Nia Therapeutics) and Nick Halper (Co-Founder of Braingrade) to discuss memory, and memory enhancement applications of BCI. Like many of you I approached, and to some extent still do approach, the concept of memory enhancement with skepticism. But the conversation today is going to be a grounded one, and I think you will see that there is some real science here that can give us reason to be cautiously optimistic about the future of memory and BCI. I hope you enjoy the episode. - Matt Angle Check out full video with transcript here: https://www.paradromics.com/podcast/neurotech-pub-episode-8-the-drinks-bring-back-all-the-memories 00:43 | Guest Introductions 07:38 | Types of Memory 26:47 | Building a Memory Prosthetic 38:05 | Predicting the Future: BCI to Decode/Reconstruct Memory 46:26 | Clinical Evidence of Modulating Memory 1:02:52 | New Approaches For Enhancing Memory 1:17:48 | Closing the Research-Clinical Gap Want more? Follow Paradromics & Neurotech Pub on Twitter Follow Matt A , Nanthia Suthana , Dan Rizzuto , and Nick Halper on Twitter…

Neurotech Pub

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Neurotechnology Startups and the E Word 1:23:08

منذ 4 years1:23:08

1:23:08

Welcome back to Neurotech Pub! In this episode, host and Paradromics CEO, Matt Angle, brings together Karen Rommelfanger (Neurotech Ethicist, Strategist, and Associate Professor at Emory), Anna Wexler (Assistant Professor of Medical Ethics and Health Policy at UPenn), Ana Maiques (CEO of Neuroelectrics), and Stephanie Naufel Thacker (Technical Program Manager at Facebook Reality Labs). We talk about the role of ethicists in tech. Stephanie announces a new collaboration between Facebook and the Columbia NeuroRights program. We discuss data privacy, and I am mostly listening except for two excursions on 409A valuations and Disney’s The Little Mermaid. Check out full video with transcript here: https://www.paradromics.com/podcast/neurotech-pub-episode-7-neurotechnology-startups-and-the-e-word 00:30 | Guest Introductions Karen Rommelfanger, PhD Ana Maiques Stephanie Naufel Thacker, PhD Anna Wexler, PhD 01:00 | The E Word 27:29 | Innovative Businesses and Ethicists Collaboration 44:05 | What Neural Data Can Reveal 56:39 | Voices Not in the Room 1:01:18 | Eroding Privilege of Mind-Body Duality Want more? Follow Paradromics & Neurotech Pub on Twitter Follow Matt A , Karen Rommelfanger , Ana Maiques , & Anna Wexler, PhD on Twitter…

Neurotech Pub

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Cyborgs That Smell 1:15:07

منذ 4 years1:15:07

1:15:07

Welcome back to Neurotech Pub! In this episode, host and Paradromics CEO, Matt Angle, discusses the science of olfaction with Andreas Schaefer, Gabe Lavella, and Dima Rinberg. Gabe and Dima also unveil their new startup, Canaery, which uses BCI-enhanced animals to digitize the olfactory world. Check out full video with transcript here: https://www.paradromics.com/podcast/neurotech-pub-episode-6-cyborgs-that-smell 00:10 | Guest Introductions 00:43 | What They Wanted to Be When They Were 8 Years Old 09:21 | What You Don't Know About Olfaction That You Should 16:17 | Dimensionality in Olfactory Space 22:26 | Architecture of the Olfactory System 31:24 | Natural and Artificial Olfaction 38:19 | State of the Art of Olfaction Neural Recording Modalities 46:21 | Engineered Olfactory Receptors 51:32 | Implications of High Data-Rate Olfactory BCI 1:06:19 | Olfaction Resources Want more? Follow Paradromics & Neurotech Pub on Twitter Follow Matt A Andreas Schaefer and Dima Rinberg on Twitter…

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