JAMA editors and authors explain the methods underlying clinical research to help students, trainees, and health professionals use the published medical literature to make evidence-based decisions for patients. JAMAevidence is an evidence-based medicine (EBM) resource created and maintained by the JAMA Network to promote the use of EBM to improve patient care.
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Drs Gordon and Parpia have a unique and proven approach to healing chronic conditions with over 50 years of clinical experience combined; they created the Gordon Medical Forum Podcast to introduce some of the most overlooked and important factors for overcoming chronic illness. Eric Gordon, MD, is the Medical Director of Gordon Medical Associates, and Nafysa Parpia, ND, is the Director of Naturopathic Medicine. Gordon Medical Associates is the premiere tick-borne illness, Lyme disease, and e ...
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This episode explores the latest research in the complex world of Long COVID and its intersection with chronic illness. Our guest, Gez Medinger, an investigative science journalist specializing in Long COVID, sits down with Dr. Eric Gordon to discuss the latest research and challenges faced by those suffering from this condition. They touch on the …
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Teachers' Guides to the Users' Guides
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Mark C. Wilson MD, MPH, University of Iowa, discusses Teachers’ Guides to the Users’ Guides with Gordon H. Guyatt, MD, MSc, McMaster University. Related Content: Evidence vs Consensus in Clinical Practice Guidelines How to Interpret and Use a Clinical Practice Guideline or Recommendation
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Pathogens, Toxins, and Their Link to Encephalopathy
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Encephalopathy, a silent disruptor of brain function often triggered by unseen forces in our environment, affects individuals across the lifespan, from children to teenagers and seniors. Dr. Nafysa Parpia sits down with pediatric neurologist Dr. Melanie Alarcio to examine the complex interactions between pathogens, toxins, and our genetic makeup, r…
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When Symptoms Are Driven By Structure: Craniocervical Instability Explained
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With decades of experience in treating complex chronic illnesses, Dr. Eric Gordon has identified Craniocervical Instability (CCI) as a crucial, yet often overlooked, factor in persistent health challenges. This structural issue, involving the junction where the head meets the neck, can significantly impact a wide array of chronic health problems. I…
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Long COVID's Neurological Footprint: Chiropractic Neurology's Role in Treatment
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As the medical community struggles to address the complex and persistent neurological effects of Long COVID, innovative approaches to healing are desperately needed. Dr. Nafysa Parpia has successfully incorporated chiropractic neurology into her protocols not only for Long COVID patients but also for many of her complex chronic illness patients. In…
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The Science of Sound And How It Impacts Our Physical Health
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Sound is a fundamental force in our world, capable of evoking powerful emotions and physiological responses. From the cry of a baby to the soothing melodies of our favorite songs, sound shapes our experiences in profound ways. While we've long understood its emotional impact, science is now uncovering the deep connections between sound, our bodies,…
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Toxic Transition: How Menopause Unleashes Hidden Heavy Metals
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Why do some of us suddenly feel so sick, even when nothing seems to have changed? This question has left countless women puzzled and frustrated during perimenopause and post-menopause when they are hit with a wave of unexplained symptoms such as fatigue, brain fog, aches, and pains. In this episode, Dr. Nafysa Parpia sits down with Laura Frontiero …
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Tailored Healing: Personalized Lyme Disease Treatment
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At Gordon Medical Associates, we are deeply committed to the topic of Lyme disease treatment due to the prevalence of misinformation surrounding its management. Both acute and chronic Lyme disease are frequently treated inappropriately, which exacerbates the problem and contributes to the increase in chronic cases. Recognizing the urgency and compl…
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Chronic Fatigue, Long COVID, and the Mitochondrial Network
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The connection between the mitochondrial network, chronic fatigue, and Long COVID is rooted in the critical role mitochondria play in cellular energy production. Chronic fatigue and Long COVID both often result from mitochondrial dysfunction, where the cells' energy factories fail to meet the body's demands, leading to persistent fatigue. Modern-da…
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Hypercoagulation and Persistent Microclots in Long COVID
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Hypercoagulation and persistent microclots represent another component to explore as we study complex chronic illness. Long COVID has brought this issue into the limelight and has intensified the research into this issue. Hypercoagulation has been suspected of contributing to autoimmune disorders, Lyme Disease, ME/CFS, and fibromyalgia. Dr. Jordan …
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Effects of Environmental Toxins on Brain Health
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Environmental toxins wield a profound influence on brain health and the nervous system, affecting cognitive function, mood regulation, and neurological integrity. Various environmental factors, including pollution, heavy metals, pesticides, and electromagnetic fields (EMFs), can penetrate the blood-brain barrier, posing significant threats to brain…
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The Link Between Mast Cell Activation Syndrome and Chronic Illness
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Mast Cell Activation Syndrome (MCAS) is a complex immunological condition characterized by the abnormal activation of mast cells, which are crucial players in the body's allergic response. Often overlooked or misdiagnosed, MCAS can manifest in various forms, affecting multiple organ systems and presenting symptoms that mimic those of other diseases…
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Navigating the uncertainty of potential Lyme disease, mold exposure, or a combination of both can be a challenging and perplexing journey. Symptoms of these conditions often overlap, making it difficult to pinpoint the root cause. The elusive nature of Lyme disease, coupled with the stealthy effects of mold toxicity, can create a complex web of hea…
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Silent Waves of Healing: Sleep & Your Glymphatic System
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Unlocking the potential of the glymphatic system unveils a profound avenue for healing complex chronic illness and promotes cognitive vitality and neurological well-being. Operating primarily during sleep, the glymphatic system acts as the brain's self-cleaning mechanism, efficiently clearing metabolic waste and toxins that accumulate during wakefu…
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Peptides and the Chronic Illness Equation
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Unlock the secrets of cellular communication with Drs Eric Gordon and Nafysa Parpia. They delve into the microscopic world of peptides—the minuscule proteins wielding monumental influence over your body and mind. Comprising short chains of amino acids, these tiny powerhouses orchestrate specific functions within your cells, playing a pivotal role i…
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Exploring Sinus-Related Cognitive Connections
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Join Dr. Parpia in the latest episode of Gordon Medical Forum as she navigates the intricate web of potential causes for cognitive decline with Dr. Josh Helman. From Lyme and co-infections to mold/mycotoxins, high viral loads, and environmental toxicants, discover why the health of our sinuses holds profound significance for brain health and cognit…
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Every single day, Dr. Eric Gordon and Dr. Nafysa Parpia navigate the intricate landscape of patients grappling with multifaceted chronic illnesses. Each individual presents a unique puzzle, with an array of symptoms and interwoven medical complexities. Navigating the realm of complex health issues amidst a sea of bewildering information can be a da…
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Assessing the Strength of Recommendations: The GRADE Approach With Dr Vandvik
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Gordon H. Guyatt, MD, MSc, discusses Assessing the Strength of Recommendations: The GRADE Approach with Per Olav Vandvik, MD, PhD. Related Content: How to Interpret and Use a Clinical Practice Guideline or Recommendation
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Understanding and Applying the Results of a Systematic Review With Dr Murad
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Host Gordon Guyatt, MD, MSc, discusses Understanding and Applying the Results of a Systematic Review with M. Hassan Murad, MD, MPH. Related Content: How to Read a Systematic Review and Meta-analysis and Apply the Results to Patient Care Acute Treatments for Episodic Migraine in Adults
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Fixed-Effects and Random-Effects Models With Dr Murad
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Gordon H. Guyatt, MD, MSc, discusses Fixed-Effects and Random-Effects Models with M. Hassan Murad, MD. Related Content: Random-Effects Meta-analysis
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Adjusted Analyses in Studies Addressing Therapy and Harm With Dr Agoritsas
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Gordon H. Guyatt, MD, MSc, discusses Adjusted Analyses in Studies Addressing Therapy and Harm with Thomas Agoritsas, MD, PhD. Related Content: Adjusted Analyses in Studies Addressing Therapy and Harm
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Spectrum Bias With Dr Reem A. Mustafa
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Gordon Guyatt, MD, MSc, discusses Spectrum Bias with Reem A. Mustafa. MD, MPH, PhD.
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Discrimination and Calibration of Clinical Prediction Models With Dr Alba
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Gordon Guyatt, MD, MSc, discusses Discrimination and Calibration of Clinical Prediction Models with Ana Carolina Alba, MD, PhD. Related Content: Discrimination and Calibration of Clinical Prediction Models With Dr Alba Read Transcript
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How to Interpret and Use a Clinical Practice Guideline or Recommendation With Dr Gordon Guyatt and Dr Brignardello-Petersen
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Host Robert M. Golub, MD, discusses How to Interpret and Use a Clinical Practice Guideline or Recommendation with Gordon H. Guyatt, MD, MSc, and Romina Brignardello-Petersen, DDS, MSc, PhD.
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Measuring Agreement Beyond Chance With Dr Thomas McGinn
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Gordon Guyatt, MD, discusses Measuring Agreement Beyond Chance with Thomas McGinn, MD, MPH. Related Content: Does This Patient Have Infectious Mononucleosis? The Rational Clinical Examination Systematic Review
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Correlation and Regression With Dr Jaeschke
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Gordon H. Guyatt, MD, MSc, discusses
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Economic Analysis With Dr Paul Moayyedi
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Gordon Guyatt, MD, discusses economic analysis with Paul Moayyedi, PhD
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Misleading Presentations of Clinical Trial Results with Dr Victor Montori
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Gordon Guyatt, MD, discusses Misleading Presentations of Clinical Trial Results with Victor Montori, MD Related Content: Misleading Presentations of Clinical Trial Results with Dr Victor Montori When Can Intermediate Outcomes Be Used in Clinical Trials? When Guidelines Recommend Shared Decision-making…
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Surrogate Outcomes from the Users’ Guides to the Medical Literature
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Anne M. Holbrook, MD and Gordon Guyatt, MD, discuss Surrogate Outcomes from the JAMA Users’ Guides to the Medical Literature Related Content: When Can Intermediate Outcomes Be Used as Surrogate Outcomes? FDA Acceptance of Surrogate End Points for Cancer Drug Approval: 1992-2019 What Constitutes a Valid Surrogate End Point in Cancer Clinical Trials?…
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How to Read Articles That Use Machine Learning With Yun Liu, PhD
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Interview with Yun Liu, author of How to Read Articles That Use Machine Learning: Users’ Guides to the Medical Literature
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Cluster Randomized Trials: Evaluating Treatments Applied to Groups With William J. Meurer, MD
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JAMA Deputy Editor Edward Livingston, MD, discusses "Cluster Randomized Trials: Evaluating Treatments Applied to Groups" With William J. Meurer, MD, MS
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Dose-Finding Trials: Optimizing Phase 2 Data in the Drug Development Process with Dr Kert Viele
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Ed Livingston, MD, FACS, AGAF, discusses Dose-Finding Trials: Optimizing Phase 2 Data in the Drug Development Process with Kert Viele, PhD
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Noninferiority Trials: Is a New Treatment Almost as Effective as Another? with Dr Amy Kaji
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Ed Livingston, MD, FACS, AGAF, discusses Noninferiority Trials: Is a New Treatment Almost as Effective as Another? with Amy Kaji, MD, PhD
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Decision-making and the Patient with Dr Victor Montori
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Gordon Guyatt, MD, MSc, discusses Decision-making and the Patient with Victor Montori, MD, MSc.
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JAMA Guide to Statistics and Methods
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Clinical researchers and biostatisticians use highly specialized language to help them discuss statistics and research methods efficiently. In 2019 JAMA published the JAMA Guide to Statistics and Methods, a book of short reviews that translate that specialized language and explain statistics and methods to a broad physician readership. The book's e…
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Applying Results to Individual Patients with Dr Thomas Agoritsas
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Gordon Guyatt, MD, MSc, discusses the application of the results of systematic reviews and meta-analyses to individual patients with author Thomas Agoritsas, MD.
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How to Use a Subgroup Analysis with Dr Gordon Guyatt
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Dr Edward Livingston discusses How to Use a Subgroup Analysis with Dr Gordon Guyatt
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Composite End Points With Dr Gordon Guyatt
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Dr Ed Livingston discusses Composite End Points with Gordon Guyatt
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Differential Diagnosis With Dr Scott Richardson
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Dr Gordon Guyatt discusses Differential Diagnosis with Scott Richardson
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How to Use an Article About Genetic Association With Dr John Attia
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Dr Gordon Guyatt discusses How to Use an Article About Genetic Association with Dr John Attia
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How to Use an Article About Hypothesis Testing and Appropriate Interpretation of P Values: Interview With Dr George Tomlinson
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Demetrios N. Kyriacou discusses How to Use an Article About Hypothesis Testing and Appropriate Interpretation of P Values with Dr George Tomlinson
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Dr David Simel discusses Obstructive Sleep Apnea with Dr Kathryn A. Myers.
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How to Use an Article About Quality Improvement: Interview With Dr Eddy Fan
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Dr Demetrios Kyriacou discusses How to Use an Article About Quality Improvement with Dr Eddy Fan.
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Network Meta-analysis: Interview With Dr Gordon Guyatt
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Dr Demetrios Kyriacou discusses Network Meta-analysis with Dr Gordon Guyatt.
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The Principle of Intention to Treat and Ambiguous Dropouts: Interview With Dr Matthias Briel
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Dr Amy Thompson discusses the Principle of Intention to Treat and Ambiguous Dropouts with Dr Matthias Briel.
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Evidence-Based Medicine and the Theory of Knowledge: Interview With Dr Gordon Guyatt
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Dr Amy Thompson discusses Evidence-Based Medicine and the Theory of Knowledge with Dr Gordon Guyatt.
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Clinical Prediction Rules: Interview With Dr Thomas G. McGinn
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Dr Ed Livingston discusses Clinical Prediction Rules with Dr Thomas G. McGinn.
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Recommendations About Screening: Interview With Gemma Louise Jacklyn
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Dr Ed Livingston discusses Recommendations About Screening with Gemma Louise Jacklyn.
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How to Use a Noniferiority Trial: Interview With Dr Gordon Guyatt
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Dr Ed Livingston discusses How to Use a Noniferiority Trial with Dr Gordon Guyatt.
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The Process of a Systematic Review and Meta-analysis: Interview With Dr M. Hassan Murad
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Dr Ed Livingston discusses Systematic Review and Meta-analysis with Dr M. Hassan Murad.
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