009 - Ethics: Life Support after Brain Death

Topics in Palliative Medicine

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In Her Ellement

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Navigating Career Pivots and Grit with Milo’s Avni Patel Thompson 26:18

منذ 22 يومًا26:18

التشغيل لاحقا

قوائم

إعجاب

احب

26:18

How do you know when it’s time to make your next big career move? With International Women’s Day around the corner, we are excited to feature Avni Patel Thompson, Founder and CEO of Milo. Avni is building technology that directly supports the often overlooked emotional and logistical labor that falls on parents—especially women. Milo is an AI assistant designed to help families manage that invisible load more efficiently. In this episode, Avni shares her journey from studying chemistry to holding leadership roles at global brands like Adidas and Starbucks, to launching her own ventures. She discusses how she approaches career transitions, the importance of unpleasant experiences, and why she’s focused on making everyday life easier for parents. [01:26] Avni's University Days and Early Career [04:36] Non-Linear Career Paths [05:16] Pursuing Steep Learning Curves [11:51] Entrepreneurship and Safety Nets [15:22] Lived Experiences and Milo [19:55] Avni’s In Her Ellement Moment [20:03] Reflections Links: Avni Patel Thompson on LinkedIn Suchi Srinivasan on LinkedIn Kamila Rakhimova on LinkedIn Ipsos report on the future of parenting About In Her Ellement: In Her Ellement highlights the women and allies leading the charge in digital, business, and technology innovation. Through engaging conversations, the podcast explores their journeys—celebrating successes and acknowledging the balance between work and family. Most importantly, it asks: when was the moment you realized you hadn’t just arrived—you were truly in your element? About The Hosts: Suchi Srinivasan is an expert in AI and digital transformation. Originally from India, her career includes roles at trailblazing organizations like Bell Labs and Microsoft. In 2011, she co-founded the Cleanweb Hackathon, a global initiative driving IT-powered climate solutions with over 10,000 members across 25+ countries. She also advises Women in Cloud, aiming to create $1B in economic opportunities for women entrepreneurs by 2030. Kamila Rakhimova is a fintech leader whose journey took her from Tajikistan to the U.S., where she built a career on her own terms. Leveraging her English proficiency and international relations expertise, she discovered the power of microfinance and moved to the U.S., eventually leading Amazon's Alexa Fund to support underrepresented founders. Subscribe to In Her Ellement on your podcast app of choice to hear meaningful conversations with women in digital, business, and technology.…

منذ عام واحد 21:02

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This article presents an ethics case study concerning a 52-year-old male declared brain dead, whose family refuses to remove life support. Multiple perspectives—medical, nursing, chaplain, social work, legal, and ethical—are offered, exploring the conflict between the family's emotional denial of death and the medical team's obligation to uphold accepted medical standards. The case highlights the complexities of defining death in the modern era, the importance of cultural sensitivity in end-of-life care, and the challenges of navigating legal and ethical considerations when families disagree with medical assessments. The discussion examines various ethical frameworks, including Kantian ethics and utilitarianism, to guide decision-making. Ultimately, the article emphasizes the need for compassion and patience in dealing with grieving families while upholding medical and legal standards.

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Thank you for your interest in Ethics in Palliative Medicine! Follow us at https://epionepalliative.com and on X: @PallCareEthics

15 حلقات

#Fitness #Society #Podcasting Education #Medicine #Philosophy #EthicsDoc

Topics in Palliative Medicine

009 - Ethics: Life Support after Brain Death

Topics in Palliative Medicine

published منذ عام واحد

MP3•منزل الحلقة

Questions? Comments? Send us a message!

Support the show

Thank you for your interest in Ethics in Palliative Medicine! Follow us at https://epionepalliative.com and on X: @PallCareEthics

15 حلقات

#Fitness #Society #Podcasting Education #Medicine #Philosophy #EthicsDoc

كل الحلقات

Topics in Palliative Medicine

1
015 - Ethics: A Mother in Jeopardy: The Ethics of Pregnancy and Chemotherapy 17:17

منذ 14 يومًا17:17

17:17

Questions? Comments? Send us a message! In this episode, we discuss a complex ethical dilemma concerning a pregnant woman diagnosed with advanced ovarian cancer who refuses recommended termination and chemotherapy due to prior fertility struggles. Several experts in medicine, ethics, law, spiritual care, and social work provide differing perspectives on the case. The medical oncology perspective discusses the individualized management of cancer during pregnancy, while the ethics perspective grapples with patient autonomy versus the potential harm to both mother and fetus. The legal and social work perspectives emphasize the patient's right to self-determination. Ultimately, the article advocates for a multidisciplinary approach that respects the patient's wishes while providing comprehensive support and information. It highlights the need for healthcare providers to navigate these difficult situations with compassion and discernment. Support the show Thank you for your interest in Ethics in Palliative Medicine! Follow us at https://epionepalliative.com and on X: @PallCareEthics…

Topics in Palliative Medicine

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014 - Symptom Management: Botulinum Toxin for Post Thoracotomy Pain Syndrome 19:06

منذ 27 يومًا19:06

19:06

Questions? Comments? Send us a message! This case report explores the use of botulinum toxin type A (BTX-A) injections for treating post-thoracotomy pain syndrome (PTPS), a chronic neuropathic condition affecting many patients after thoracotomy. The study highlights that traditional treatments often fail to provide adequate relief, prompting investigation into alternative therapies. BTX-A's mechanism, which involves reducing inflammation and peripheral neurotransmitters, suggests a potential benefit for localized pain syndromes like PTPS. Prior studies indicate the effectiveness of BTX-A in managing other neuropathic pain conditions such as trigeminal neuralgia and diabetic neuropathy. The case report details a successful instance where subcutaneous BTX-A injections significantly alleviated PTPS symptoms, allowing the patient to discontinue opioid medications. While the treatment appears promising and carries minimal risk, the authors suggest that further clinical trials should be conducted. Support the show Thank you for your interest in Ethics in Palliative Medicine! Follow us at https://epionepalliative.com and on X: @PallCareEthics…

Topics in Palliative Medicine

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013 - Symptom Management: Dronabinol for Neuropathic Pain 18:22

منذ 6 weeks18:22

18:22

Questions? Comments? Send us a message! I. Introduction This briefing document synthesizes key findings from several sources exploring the potential of cannabinoids in managing neuropathic pain. The sources include pre-clinical investigations, clinical trial reviews, and decision analysis models, offering a multifaceted view of the topic. We will examine the potential of Cannabidiolic Acid Methyl Ester (CBDA-ME), the effectiveness of cannabis-based medicines, and compare these to traditional pain management techniques. II. Pre-Clinical Investigation: CBDA-ME Focus: The research primarily centers around CBDA-ME, a modified version of cannabidiolic acid (CBDA), which has been enhanced for stability. The study investigates its analgesic effects in rats with peripherally induced neuropathic pain, considering sex as a biological variable. Key Findings: Improved Stability: CBDA is unstable which limits its potential as a therapeutic target. The addition of the methyl ester group enhances its stability in in vivo studies. Dose-Dependent Analgesic Effects (Males): CBDA-ME exhibited a clear dose-dependent increase in mechanical pain threshold in male rats, with a significant reduction in sensitivity to touch. The most effective dose was 1 μg/kg. For example, at week 5, the 1 μg/kg group showed a mechanical threshold of 12.27g compared to a 4.70g for the vehicle group. By week 8, the same groups had thresholds of 12.56g vs 3.53g respectively. Inconsistent Results (Females): Female rats showed less consistent responses to CBDA-ME, with some increase in mechanical threshold at weeks 3-5 at 1 μg/kg, but less pronounced and less sustained than in males. At week 5 females had a threshold of 8.81g in the high dose group compared to 4.33g in the vehicle group. At week 8 the numbers were 6.20g vs 5.26g. Impact on Thermal Thresholds: The study found less clear or consistent effects of CBDA-ME on thermal thresholds. Reduced Neuronal Excitability: CBDA-ME reduced the excitability of specific sensory neuron types (AβHTM, CUT, CHTM, CLTM) by decreasing the current threshold required to evoke an action potential, suggesting a mechanism for its analgesic effect. Quote: "This study examines early treatment efficacy of CBDA-ME in a rat model of peripherally induced NEP and evaluates sex as a biological variable." Implications: These findings suggest CBDA-ME as a potential analgesic, particularly for mechanical pain, with significant sex differences that need further investigation. III. Clinical Trial Review: Cannabis-Based Medicines (CBMs) Source Focus: A Cochrane review examining the effectiveness of CBMs for chronic neuropathic pain in adults. Key Findings: Herbal Cannabis: The review found that herbal cannabis was not significantly different from placebo in reducing pain or causing dropouts due to side effects, rated as very low-quality evidence. Short-Term Studies: CBMs were not superior to placebo in short-term studies for pain reduction or patient-reported global improvement. Intermediate-Term Studies: Some studies showed slight superiority of CBMs over placebo in intermediate-term studies, but these were marginal and sometimes lacked statistical significance, such as a positive Risk Difference in studies reporting improvement in pain (RD=0.03 95% CI 0.00 to 0.06, p=0.05), and similar results reported for a composite measure of improved function Support the show Thank you for your interest in Ethics in Palliative Medicine! Follow us at https://epionepalliative.com and on X: @PallCareEthics…

Topics in Palliative Medicine

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012 - Symptom Management: Gabapentin for Intractable Hiccups 15:32

منذ 8 weeks15:32

15:32

Questions? Comments? Send us a message! Hiccups, while often seen as a minor inconvenience, can become a significant health issue when they are persistent or intractable. This episode explores the science behind hiccups, their potential medical causes, and treatment options, particularly the use of gabapentin as an off-label solution. • Discussion of the three types of hiccups: acute, persistent, and intractable • Explanation of the hiccup reflex arc and its neurological basis • Overview of the myriad causes of intractable hiccups, including central nervous system and psychological factors • Introduction and definition of gabapentin, including its off-label use for hiccups • Presentation of case studies demonstrating the efficacy of gabapentin • Examination of potential side effects of gabapentin relative to other treatments • Alternatives to gabapentin, including other medications and non-pharmacological home remedies • Ethical considerations regarding off-label prescriptions and open communication with doctors Support the show Thank you for your interest in Ethics in Palliative Medicine! Follow us at https://epionepalliative.com and on X: @PallCareEthics…

Topics in Palliative Medicine

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011 - Diagnostics: Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE) - An easily missed diagnosis in palliative medicine 10:15

منذ 9 weeks10:15

10:15

Questions? Comments? Send us a message! This case report details a patient with chronic lymphocytic leukemia whose initially misdiagnosed joint pain was ultimately attributed to the rare syndrome of remitting seronegative symmetrical synovitis with pitting edema (RS3PE). The report discusses RS3PE's characteristics, often overlooked due to its rarity and lack of definitive diagnostic criteria, emphasizing the importance of recognizing it in palliative care settings. The paper explores RS3PE's association with malignancy, its clinical presentation mimicking other rheumatological disorders, and its effective treatment with corticosteroids. Furthermore, the study investigates the potential role of vascular endothelial growth factor (VEGF) in RS3PE's pathophysiology. Early diagnosis is crucial for effective pain management and avoiding reliance on ineffective opioid treatments. Support the show Thank you for your interest in Ethics in Palliative Medicine! Follow us at https://epionepalliative.com and on X: @PallCareEthics…

Topics in Palliative Medicine

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010 - Data: Palliative Medicine Consultation and Hospital Readmissions 12:03

منذ 10 weeks12:03

12:03

Questions? Comments? Send us a message! This retrospective study from a 21-hospital system analyzed the effect of palliative medicine consultations on 30-day hospital readmission rates for patients with six diagnoses (heart failure, sepsis, pneumonia, COPD, AMI, and stroke). The research found statistically significant reductions in readmissions for heart failure, sepsis, and pneumonia patients who received consultations. While reductions were observed in other groups (stroke, AMI, COPD), these were not statistically significant. The study suggests that palliative care consultations may improve patient outcomes and reduce healthcare costs, warranting further investigation and potential policy changes. The findings add to existing literature supporting the value of palliative care in mitigating readmissions. Support the show Thank you for your interest in Ethics in Palliative Medicine! Follow us at https://epionepalliative.com and on X: @PallCareEthics…

Topics in Palliative Medicine

1
009 - Ethics: Life Support after Brain Death 21:02

منذ 11 weeks21:02

21:02

Questions? Comments? Send us a message! This article presents an ethics case study concerning a 52-year-old male declared brain dead, whose family refuses to remove life support. Multiple perspectives—medical, nursing, chaplain, social work, legal, and ethical—are offered, exploring the conflict between the family's emotional denial of death and the medical team's obligation to uphold accepted medical standards. The case highlights the complexities of defining death in the modern era, the importance of cultural sensitivity in end-of-life care, and the challenges of navigating legal and ethical considerations when families disagree with medical assessments. The discussion examines various ethical frameworks, including Kantian ethics and utilitarianism, to guide decision-making. Ultimately, the article emphasizes the need for compassion and patience in dealing with grieving families while upholding medical and legal standards. Support the show Thank you for your interest in Ethics in Palliative Medicine! Follow us at https://epionepalliative.com and on X: @PallCareEthics…

Topics in Palliative Medicine

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008 - Diagnostics: Post-radiation Lichen Planus 14:44

منذ 11 weeks14:44

14:44

Questions? Comments? Send us a message! This case report details a rare instance of post-radiation lichen planus in a 64-year-old male, following radiation therapy for squamous cell carcinoma. The report examines the patient's medical history, clinical presentation, and treatment response to topical triamcinolone. The authors review existing literature on lichen planus, emphasizing its T-cell mediated inflammatory nature and its rare association with radiation therapy. The study highlights the need for further research to understand the pathophysiology and improve treatment of this complication. The case underscores the importance of considering radiation-induced lichen planus in patients with relevant exposure and symptoms. Support the show Thank you for your interest in Ethics in Palliative Medicine! Follow us at https://epionepalliative.com and on X: @PallCareEthics…

Topics in Palliative Medicine

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007 - Diagnostics: Posterior Reversible Encephalopathy Syndrome (PRES) - Don't Miss This Diagnosis! 13:49

منذ 11 weeks13:49

13:49

Questions? Comments? Send us a message! This case report and accompanying discussion detail Posterior Reversible Encephalopathy Syndrome (PRES), a neurological condition presenting with seizures, visual disturbances, and altered mental status. Often misdiagnosed as more severe conditions like intracranial hemorrhage, PRES demonstrates reversible brain swelling on MRI. The case highlights a patient initially suspected of intracerebral hemorrhage whose diagnosis was revised to PRES, leading to successful treatment and recovery. The article also explores the etiology, diagnosis, treatment, and prognosis of PRES, including emerging links to COVID-19 infections. The authors emphasize the importance of thorough neuroimaging to ensure accurate diagnosis and avoid premature withdrawal of life support. Support the show Thank you for your interest in Ethics in Palliative Medicine! Follow us at https://epionepalliative.com and on X: @PallCareEthics…

Topics in Palliative Medicine

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006 - Symptom Management: BJR Method for Methadone Conversion 16:05

منذ 12 weeks16:05

16:05

Questions? Comments? Send us a message! The BJR method is a novel mathematical approach to methadone conversion that aims to improve upon existing methods by providing a smoother, less discontinuous, and less linear output for a reasonable and safe methadone dose. Here's how it improves upon existing conversion approaches: Addresses Limitations of the Plonk Method: The Plonk method uses a linear equation to calculate methadone dosage, which assumes a linear relationship between methadone and morphine. This method is considered useful only in the lower range of morphine equivalent doses (300-600mg), and it calculates overly high doses of methadone at higher morphine doses. The BJR method, in contrast, uses a parabolic equation, which is thought to more accurately reflect the relationship between morphine and methadone dosage. Reduces Discontinuities of the Ayonrinde Method : The Ayonrinde method uses a changing-ratio approach that takes into account the need for lower relative doses of methadone with escalating morphine equivalents. However, this method has significant discontinuities at the ratio transition points. The BJR method produces a smoother curve without these abrupt changes. Provides a Starting Dose: Unlike the Ayonrinde method which intercepts the y-axis at zero, the BJR method, similar to the Plonk method, outputs a starting dose for opioid-naive patients. The BJR method's y-intercept is set at 15mg, which is the starting dose for opioid-naive patients, though this may be adjusted to 7.5mg or less for frail elderly patients. Moderates Doses at Higher Levels: At higher doses of oral morphine, the BJR method outputs lower doses of methadone than other methods, including the Ayonrinde method. This is intended to improve patient safety by reducing the risk of excessive sedation and respiratory depression. Simplified Formula: The BJR method provides a simple formula for methadone conversion, which does not require conversion tables and protocols. This can be a useful tool in palliative medicine. The formula is as follows: methadone mg = 1.5 * √(morphine mg) + 15 In summary, the BJR method is designed to address some of the limitations of existing methadone conversion methods, aiming to provide a safer, more accurate, and more convenient approach to methadone dosing. The method has shown promising results in case studies, and it provides a simplified model for conversion that may be useful in palliative medicine. However, it requires further validation before it can become a standard of care. **NOTE: THIS IS FOR ACADEMIC PURPOSES ONLY. DO NOT ACT ON ANYTHING IN THIS PODCAST WITHOUT CONSULTING AN EXPERIENCED MEDICAL PROFESSIONAL.** Support the show Thank you for your interest in Ethics in Palliative Medicine! Follow us at https://epionepalliative.com and on X: @PallCareEthics…

Topics in Palliative Medicine

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005 - Cultural: The Therapeutic Baptism : A Case of Missed Cultural Cues in a Terminally Ill Patient 27:27

منذ 12 weeks27:27

27:27

Questions? Comments? Send us a message! The case study underscores the potential for misinterpreting spiritual distress as psychiatric illness, resulting in inappropriate treatment. Clinicians should learn several key lessons from the case of Mr. G, primarily emphasizing the importance of addressing patients' spiritual needs alongside their physical ailments. Open communication: Clinicians should initiate open-ended questions about a patient's spiritual beliefs as part of a routine assessment. Questions like "do you consider yourself religious" or "do you want to discuss spiritual matters with me" can help identify patients who wish to discuss these topics. Clinicians should also be attentive to cues from patients that may indicate spiritual concerns. For example, a patient commenting on a painting in the doctor’s office can be a cue to explore the patient's spiritual or emotional state. Holistic approach: The case illustrates the importance of a whole-person approach to care, recognizing that physical symptoms can be intertwined with spiritual and emotional distress. In Mr. G's case, his physical symptoms and anxiety about death were directly connected to his belief that he needed to be baptized to avoid hell. Avoid assumptions: Clinicians should avoid making assumptions about a patient's beliefs or motivations, and not dismiss them as psychiatric issues. Mr. G's statements about a "demon" in his abdomen were initially misinterpreted as paranoia, when they were a manifestation of his spiritual concerns. Spiritual needs may drive medical decisions: Spiritual distress can lead patients to make medical decisions that might seem illogical from a purely medical perspective, such as requesting aggressive life-sustaining measures when they are terminally ill. Mr. G's desire to "do everything" to stay alive was driven by his fear of dying unbaptized. The power of simple interventions: Addressing a patient's spiritual needs can have profound positive impacts. In Mr. G's case, a simple baptism provided immense relief, alleviating both his spiritual distress and his physical pain. Interdisciplinary collaboration: Clinicians should be willing to collaborate with other professionals, such as chaplains, to provide comprehensive care. The chaplain in this case was able to offer a solution that the physician was not equipped to provide. The chaplain’s ability to perform the baptism "anywhere" highlights the accessibility of spiritual interventions. Listen to the patient: The case emphasizes the importance of listening to the patient. As one patient in a survey noted, "the patient is telling you something," meaning that clinicians need to pay close attention to both verbal and nonverbal cues that indicate what is important to the patient. In Mr. G's case, understanding the framework from which he was operating was essential. Reflection and growth: The physician in the case study admitted his actions were "morally and ethically reprehensible" when he attempted to change the patient's code status after the patient became unresponsive, demonstrating the importance of reflection and learning from past errors. The physician also recognized the need to talk to patients about spiritual matters and learned that failing to do so could result in needless suffering. This case was instrumental in igniting his interest in hospice and palliative care. By acknowledging the importance of spiritual well-being and actively addressing it as part of patient care, clinicians can significantly improve the quali Support the show Thank you for your interest in Ethics in Palliative Medicine! Follow us at https://epionepalliative.com and on X: @PallCareEthics…

Topics in Palliative Medicine

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004 - Ethics: Suicide and Self Determination - what are the limits to autonomy when a patient lacks capacity? 26:27

منذ 12 weeks26:27

26:27

Questions? Comments? Send us a message! This ethics roundtable discussion centers on the case of JG, a 45-year-old man who attempted suicide and subsequently suffered severe brain damage. The article presents differing perspectives from medical, nursing, risk management, ethics, pastoral, social work, and legal professionals regarding the ethical implications of his wife's request to withdraw life support and the physician's recommendation for a tracheostomy. The central ethical dilemmas explored involve patient autonomy versus beneficence and non-maleficence, especially given JG's compromised capacity to make decisions and the uncertainty surrounding his prognosis. The discussion highlights the complexities of surrogate decision-making, informed consent, and the role of the medical team in balancing patient wishes with the potential for recovery. Ultimately, the authors seek to examine the intricate considerations surrounding end-of-life care in the context of a patient's expressed desire to forgo treatment. Support the show Thank you for your interest in Ethics in Palliative Medicine! Follow us at https://epionepalliative.com and on X: @PallCareEthics…

Topics in Palliative Medicine

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002 - Ethics: Surrogacy, Religious Beliefs, and Medical Treatment 23:28

منذ 12 weeks23:28

23:28

Questions? Comments? Send us a message! Ethical and legal considerations surrounding a comatose Jehovah's Witness patient's need for a life-saving blood transfusion are debated. The patient's parents, also Jehovah's Witnesses, refuse consent, while her brother advocates for the transfusion, claiming she wasn't a practicing member. The case highlights the conflict between parental surrogacy rights , the patient's autonomy , and the physician's responsibility to provide beneficial care. Multiple perspectives—medical, nursing, social work, legal, and ethical—are offered, emphasizing the importance of understanding the patient's wishes and the limitations of surrogacy decisions based on the surrogate's beliefs. The lack of advance directives and the resulting ethical dilemma are also discussed. Support the show Thank you for your interest in Ethics in Palliative Medicine! Follow us at https://epionepalliative.com and on X: @PallCareEthics…

Topics in Palliative Medicine

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003 - Ethics: State-Erected Barriers to End-of-Life Care 11:05

منذ 12 weeks11:05

11:05

Questions? Comments? Send us a message! This ethics roundtable discussion analyzes a case study where a patient's daughter-in-law, the primary caregiver, seeks to withdraw life support, but state law restricts surrogacy to blood relatives or spouses . The discussion explores the ethical and legal implications of this restrictive law , highlighting the conflict between the patient's best interests and the letter of the law. Experts in palliative medicine, spiritual health, law, and ethics contribute varying perspectives on surrogacy, advance care planning, and the need for legal reform to better accommodate diverse family structures and patient preferences. The authors advocate for a more flexible and ethically sound approach to surrogate decision-making. Support the show Thank you for your interest in Ethics in Palliative Medicine! Follow us at https://epionepalliative.com and on X: @PallCareEthics…

Topics in Palliative Medicine

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001 - Ethics: Surrogate Decision Making at End of Life 20:40

منذ 12 weeks20:40

20:40

Questions? Comments? Send us a message! Who makes the decision if the patient lacks capacity? Multiple healthcare professionals offer varying perspectives on the ethical and legal dilemma surrounding the care of a 93-year-old comatose patient (JH). A conflict exists between JH's legally appointed Power of Attorney (POA), his hired caregiver, who wants aggressive treatment, and his son, who advocates for comfort care only. The central issue is whether to honor the POA's decision despite concerns about potential conflicts of interest and the medical futility of continued aggressive treatment. Legal and ethical frameworks are explored, along with a proposed six-step process for resolving such disputes, highlighting the complexities of surrogate decision-making in end-of-life care. Ultimately , the case underscores the need for clear advance directives and a collaborative approach to navigating difficult medical and ethical decisions. Support the show Thank you for your interest in Ethics in Palliative Medicine! Follow us at https://epionepalliative.com and on X: @PallCareEthics…

مرحبًا بك في مشغل أف ام!

يقوم برنامج مشغل أف أم بمسح الويب للحصول على بودكاست عالية الجودة لتستمتع بها الآن. إنه أفضل تطبيق بودكاست ويعمل على أجهزة اندرويد والأيفون والويب. قم بالتسجيل لمزامنة الاشتراكات عبر الأجهزة.