Finding new treatments for peanut allergy

Beyond Biotech - the podcast from Labiotech

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منذ 7 أيام18:09

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منذ عام واحد 31:06

MP3•منزل الحلقة

There is a constant risk of severe, potentially life-threatening allergic reactions for individuals with peanut allergies, which leads to significant physical, social, and emotional burdens.

IgGenix, a clinical-stage immunology biotechnology company, recently announced the first patient dosed in its phase 1 trial evaluating IGNX001, a novel monoclonal antibody-based therapeutic, for peanut allergy.

Designed to neutralize the most clinically important peanut allergens and epitopes, IGNX001 combats peanut allergies by blocking the allergic cascade and reducing risk of anaphylaxis.

Should IGNX001 prove successful, it will provide a promising solution for peanut allergies and pave the way for IgGenix's technology to be applied to other types of food allergies and allergic diseases.

Our guest on the podcast this week is Jessica Grossman, chief executive officer of IgGenix.

01:14-02:51: About IgGenix
02:51-06:30: About peanut allergy
06:30-07:31: Are allergies on the rise?
07:31-08:46: Are allergy responses similar?
08:46-10:13: The problems with treating allergies
10:13-13:53: Current treatments for peanut allergy
13:53-15:45: The challenges of developing drugs to treat allergies
15:45-16:54: Overcoming the placebo effect
16:54-18:18: Are other companies working on allergy treatments?
18:18-21:32: IgGenix’s SEQ SIFTER platform
21:32-24:20: About IgGenix’s IGNX001
24:20-24:42: Repeat doses
24:42-26:19: Could peanut allergy sufferers eat peanuts?
26:19-27:46: Can the technology be adapted to treat other allergies?
27:46-28:56: Are there variations in the treatment of different allergies?
28:56-29:35: Treatments for other diseases
29:35-30:23: The future for people with allergies

Interested in being a sponsor of an episode of our podcast? Discover how you can get involved here!

Stay updated by subscribing to our newsletter

فصول

1. Finding new treatments for peanut allergy (00:00:00)

2. About IgGenix (00:01:14)

3. About peanut allergy  (00:02:51)

4. Are allergies on the rise? (00:06:30)

5. Are allergy responses similar?  (00:07:31)

6. The problems with treating allergies  (00:08:46)

7. Current treatments for peanut allergy  (00:10:13)

8. The challenges of developing drugs to treat allergies  (00:13:53)

9. Overcoming the placebo effect  (00:15:45)

10. Are other companies working on allergy treatments?  (00:16:54)

11. IgGenix’s SEQ SIFTER platform  (00:18:18)

12. About IgGenix’s IGNX001  (00:21:32)

13. Repeat doses (00:24:20)

14. Could peanut allergy sufferers eat peanuts?  (00:24:42)

15. Can the technology be adapted to treat other allergies?  (00:26:19)

16. Are there variations in the treatment of different allergies?  (00:27:46)

17. Treatments for other diseases  (00:28:56)

18. The future for people with allergies  (00:29:35)

137 حلقات

#News #Tech News #Labiotech

Finding new treatments for peanut allergy

Beyond Biotech - the podcast from Labiotech

published منذ عام واحد

MP3•منزل الحلقة

There is a constant risk of severe, potentially life-threatening allergic reactions for individuals with peanut allergies, which leads to significant physical, social, and emotional burdens.

Designed to neutralize the most clinically important peanut allergens and epitopes, IGNX001 combats peanut allergies by blocking the allergic cascade and reducing risk of anaphylaxis.

Our guest on the podcast this week is Jessica Grossman, chief executive officer of IgGenix.

Interested in being a sponsor of an episode of our podcast? Discover how you can get involved here!

Stay updated by subscribing to our newsletter

فصول

1. Finding new treatments for peanut allergy (00:00:00)

2. About IgGenix (00:01:14)

3. About peanut allergy  (00:02:51)

4. Are allergies on the rise? (00:06:30)

5. Are allergy responses similar?  (00:07:31)

6. The problems with treating allergies  (00:08:46)

7. Current treatments for peanut allergy  (00:10:13)

8. The challenges of developing drugs to treat allergies  (00:13:53)

9. Overcoming the placebo effect  (00:15:45)

10. Are other companies working on allergy treatments?  (00:16:54)

11. IgGenix’s SEQ SIFTER platform  (00:18:18)

12. About IgGenix’s IGNX001  (00:21:32)

13. Repeat doses (00:24:20)

14. Could peanut allergy sufferers eat peanuts?  (00:24:42)

15. Can the technology be adapted to treat other allergies?  (00:26:19)

16. Are there variations in the treatment of different allergies?  (00:27:46)

17. Treatments for other diseases  (00:28:56)

18. The future for people with allergies  (00:29:35)

137 حلقات

#News #Tech News #Labiotech

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There is a constant risk of severe, potentially life-threatening allergic reactions for individuals with peanut allergies, which leads to significant physical, social, and emotional burdens. IgGenix, a clinical-stage immunology biotechnology company, recently announced the first patient dosed in its phase 1 trial evaluating IGNX001, a novel monoclonal antibody-based therapeutic, for peanut allergy. Designed to neutralize the most clinically important peanut allergens and epitopes, IGNX001 combats peanut allergies by blocking the allergic cascade and reducing risk of anaphylaxis. Should IGNX001 prove successful, it will provide a promising solution for peanut allergies and pave the way for IgGenix's technology to be applied to other types of food allergies and allergic diseases. Our guest on the podcast this week is Jessica Grossman, chief executive officer of IgGenix. 01:14-02:51: About IgGenix 02:51-06:30: About peanut allergy 06:30-07:31: Are allergies on the rise? 07:31-08:46: Are allergy responses similar? 08:46-10:13: The problems with treating allergies 10:13-13:53: Current treatments for peanut allergy 13:53-15:45: The challenges of developing drugs to treat allergies 15:45-16:54: Overcoming the placebo effect 16:54-18:18: Are other companies working on allergy treatments? 18:18-21:32: IgGenix’s SEQ SIFTER platform 21:32-24:20: About IgGenix’s IGNX001 24:20-24:42: Repeat doses 24:42-26:19: Could peanut allergy sufferers eat peanuts? 26:19-27:46: Can the technology be adapted to treat other allergies? 27:46-28:56: Are there variations in the treatment of different allergies? 28:56-29:35: Treatments for other diseases 29:35-30:23: The future for people with allergies Interested in being a sponsor of an episode of our podcast? Discover how you can get involved here! Stay updated by subscribing to our newsletter…

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منذ 15 weeks24:04

24:04

Immunology is a key area in biotech and biopharma, both in terms of R&D and sales. However, according to UK-headquartered Greywolf Therapeutics, the industry has only focused on two-thirds of the puzzle. To have an immunological effect, you must activate the body’s T cells, which cells requires a chain of three key signals. The first is antigen recognition, i.e. the initial detection of a cell by a T-cell. The second is the co-stimulation of non-antigen presenting molecules, which enhances the immune response. The final step is cytokine-mediated differentiation and expansion, which guides how T-cells target threats. Companies have focused on the second two signals, with signal 2 most commonly seen in therapies such as checkpoint inhibitors and monoclonal antibodies. Signal 3, on the other hand, can be primarily seen in therapies for autoimmune disorders, such as anti-TNF and JAK inhibitors. Greywolf Therapeutics is the first company to explore changing signal 1. The company says focusing on signal 1 applies in three key therapeutic areas: oncology, autoimmunity and virology. Greywolf’s first candidate has delivered strong results during its ongoing phase I/II trial in oncology, therefore demonstrating proof-of-mechanism and target engagement, with its next candidate well-progressed in preclinical development in autoimmunity. To tell us more about the company and its work is Pete Joyce, CEO and co-founder of Greywolf Therapeutics. 01:19-04:12: About Greywolf Therapeutics 04:12-04:51: The origins of the name 04:51-06:52: The three ‘signals’ of the mechanics of immunological responses 06:52-08:31: Treatments associated with each signal 08:31-10:09: Why is step 1 important, and why has it not been investigated for treatments? 10:09-11:28: What areas of disease is this applicable to? 11:28-12:19: How do you inhibit ERAP? 12:19-14:01: Greywolf Therapeutics’ candidates 14:01-15:11: How is this an advance on current treatments? 15:11-16:05: What is success for patients? 16:05-17:20: How does the stage of disease affect treatment? 17:20-18:09: Are other companies looking into antigen modulation? 18:09-19:47: Has this led to investment opportunities? 19:47-21:15: Next steps 21:15-21:55: Do you anticipate more interest in this space? 21:55-23:21: Attending events Interested in being a sponsor of an episode of our podcast? Discover how you can get involved here! Stay updated by subscribing to our newsletter…

1
Beyond profits: The Bill & Melinda Gates MRI's mission to combat neglected diseases 38:10

منذ 16 weeks38:10

38:10

The Bill & Melinda Gates Medical Research Institute (Gates MRI) is a non-profit medical research organization dedicated to the development and effective use of products like drugs, vaccines and monoclonal antibodies to address substantial global health concerns, for which investment incentives are limited, including malaria, tuberculosis, diarrheal diseases, and diseases that impact maternal, newborn, and child health. This week, our guest is Dr Claire Wagner, head of corporate strategy and market access at Gates MRI. Wagner has dedicated her life to global health. Her early years working in West Africa and East Africa – including five years working with the Rwanda Ministry of Health – were formative experiences for her. She helped document health sector outcomes in Rwanda and had a front row seat to the progress the country was making at the time, which led to her pursuing and obtaining an MD and MBA from Harvard. Her experiences led to her becoming one of the early employees of the Gates MRI, where she is on the executive leadership team and leads the institute's global access strategy as well as related engagement with commercial partners, financial institutions and multilaterals. She tackles the challenge of paving the way for the drugs, biologics and vaccines that the Gates MRI is developing – if they are successful in clinical trials – to be affordable and accessible to the people in low- and middle-income countries who would benefit most. In March 2024 the Gates MRI launched a phase 3 clinical trial for a tuberculosis vaccine candidate, and market access for this candidate is a top priority for Wagner. 01:51-04:47: Background on Dr Claire Wagner 04:47-06:24: Work in Rwanda 06:24-08:40: Gates MRI 08:40-12:50: Progress at Gates MRI 12:50-14:06: Gates MRI R&D priorities 14:06-16:26: The differences between Gates MRI and traditional biotechs 16:26-18:40: Gates MRI partnerships 18:40-22:52: The inequality of developing drug treatments 22:52-25:45: Return on investment 25:45-27:01: Did COVID increase global awareness? 27:01-27:44: Other companies working on treatments 27:44-31:48: Gates MRI pipeline and clinical trials 31:48-34:51: Working on tuberculosis 34:51-36:00: Treatment mode of action 36:00-37:25: Future work at Gates MRI Interested in being a sponsor of an episode of our podcast? Discover how you can get involved here! Stay updated by subscribing to our newsletter…

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مشابه لـBeyond Biotech - the podcast from Labiotech

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Beyond Biotech - the podcast from Labiotech « » Finding new treatments for peanut allergy

فصول

1. Finding new treatments for peanut allergy (00:00:00)

2. About IgGenix (00:01:14)

3. About peanut allergy (00:02:51)

4. Are allergies on the rise? (00:06:30)

5. Are allergy responses similar? (00:07:31)

6. The problems with treating allergies (00:08:46)

7. Current treatments for peanut allergy (00:10:13)

8. The challenges of developing drugs to treat allergies (00:13:53)

9. Overcoming the placebo effect (00:15:45)

10. Are other companies working on allergy treatments? (00:16:54)

11. IgGenix’s SEQ SIFTER platform (00:18:18)

12. About IgGenix’s IGNX001 (00:21:32)

13. Repeat doses (00:24:20)

14. Could peanut allergy sufferers eat peanuts? (00:24:42)

15. Can the technology be adapted to treat other allergies? (00:26:19)

16. Are there variations in the treatment of different allergies? (00:27:46)

17. Treatments for other diseases (00:28:56)

18. The future for people with allergies (00:29:35)

Finding new treatments for peanut allergy

فصول

1. Finding new treatments for peanut allergy (00:00:00)

2. About IgGenix (00:01:14)

3. About peanut allergy (00:02:51)

4. Are allergies on the rise? (00:06:30)

5. Are allergy responses similar? (00:07:31)

6. The problems with treating allergies (00:08:46)

7. Current treatments for peanut allergy (00:10:13)

8. The challenges of developing drugs to treat allergies (00:13:53)

9. Overcoming the placebo effect (00:15:45)

10. Are other companies working on allergy treatments? (00:16:54)

11. IgGenix’s SEQ SIFTER platform (00:18:18)

12. About IgGenix’s IGNX001 (00:21:32)

13. Repeat doses (00:24:20)

14. Could peanut allergy sufferers eat peanuts? (00:24:42)

15. Can the technology be adapted to treat other allergies? (00:26:19)

16. Are there variations in the treatment of different allergies? (00:27:46)

17. Treatments for other diseases (00:28:56)

18. The future for people with allergies (00:29:35)

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مرحبًا بك في مشغل أف ام!

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مشابه لـBeyond Biotech - the podcast from Labiotech

دليل مرجعي سريع

Beyond Biotech - the podcast from Labiotech « »
Finding new treatments for peanut allergy

3. About peanut allergy  (00:02:51)

5. Are allergy responses similar?  (00:07:31)

6. The problems with treating allergies  (00:08:46)

7. Current treatments for peanut allergy  (00:10:13)

8. The challenges of developing drugs to treat allergies  (00:13:53)

9. Overcoming the placebo effect  (00:15:45)

10. Are other companies working on allergy treatments?  (00:16:54)

11. IgGenix’s SEQ SIFTER platform  (00:18:18)

12. About IgGenix’s IGNX001  (00:21:32)

14. Could peanut allergy sufferers eat peanuts?  (00:24:42)

15. Can the technology be adapted to treat other allergies?  (00:26:19)

16. Are there variations in the treatment of different allergies?  (00:27:46)

17. Treatments for other diseases  (00:28:56)

18. The future for people with allergies  (00:29:35)

3. About peanut allergy  (00:02:51)

5. Are allergy responses similar?  (00:07:31)

6. The problems with treating allergies  (00:08:46)

7. Current treatments for peanut allergy  (00:10:13)

8. The challenges of developing drugs to treat allergies  (00:13:53)

9. Overcoming the placebo effect  (00:15:45)

10. Are other companies working on allergy treatments?  (00:16:54)

11. IgGenix’s SEQ SIFTER platform  (00:18:18)

12. About IgGenix’s IGNX001  (00:21:32)

14. Could peanut allergy sufferers eat peanuts?  (00:24:42)

15. Can the technology be adapted to treat other allergies?  (00:26:19)

16. Are there variations in the treatment of different allergies?  (00:27:46)

17. Treatments for other diseases  (00:28:56)

18. The future for people with allergies  (00:29:35)