New treatments being developed for schizophrenia

Beyond Biotech - the podcast from Labiotech

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1
Mack Dryden "Dentist Visit" Bonus Show #119 7:46

منذ 7 أيام7:46

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إعجاب

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7:46

Send us a text On this very funny short Bonus Show, standup comic Mack Dryden shares his story about going to the Dentist...you'll never believe what happens...Hilarious! Look for Mack Dryden's "NEW" Dry Bar Comedy Special... Please Listen, Enjoy, and Share where you can...Thanks!! Support the show Standup Comedy Podcast Network.co www.StandupComedyPodcastNetwork.com Free APP on all Apple & Android phones....check it out, podcast, jokes, blogs, and More! For short-form standup comedy sets, listen to: "Comedy Appeteasers" , available on all platforms. New YouTube site: https://www.youtube.com/@standupcomedyyourhostandmc/videos Videos of comics live on stage from back in the day. Please Write a Review: in-depth walk-through for leaving a review. Interested in Standup Comedy? Check out my books on Amazon... "20 Questions Answered about Being a Standup Comic" "Be a Standup Comic...or just look like one"…

منذ عام واحد 25:31

MP3•منزل الحلقة

It would appear that 2024 is shaping up to be a big year for the development of treatments for schizophrenia, with several clinical trials under way.

Recently, Boehringer Ingelheim and Sosei Group Corporation (Sosei Heptares) announced a global collaboration and exclusive option-to-license agreement. This is to develop and commercialize Sosei Heptares’ portfolio of first-in-class GPR52 agonists, a novel G protein-coupled receptor (GPCR) target. The goal is to improve patient outcomes by addressing the positive, negative, and cognitive symptoms of schizophrenia.
Clíona MacSweeney, Sosei Heptares’ GPR52 program leader, spoke with us about that partnership, as well as other developments in the field of schizophrenia treatments.

00:57-03:44: What is schizophrenia?
03:44-04:52: What are the current schizophrenia treatments?
04:52-06:27: Why is schizophrenia challenging to treat?
06:27-07:34: Why is 2024 a big year for schizophrenia treatments?
07:34-08:56: Seratonin and dopamine modulation
08:56-10:46: How does muscarinic modulation work?
10:46-12:35: Excitatory and inhibitory tone pipeline
12:35-14:12: Digital therapeutic and epigenetic modulation
14:12-16:12: GPR52 agonists
16:12-17:53: How are GPR52 agonists different?
17:53-19:03: Are there lots of schizophrenia treatments coming?
19:03-20:10: Will some new schizophrenia treatments be used in conjunction with existing treatments?
20:10-20:49: Is a schizophrenia cure possible?
20:49-21:22: Treatment frequency
21:22-22:21: Where is Sosei Heptares with clinical trials for schizophrenia?
22:21-22:45: What else is in Sosei Heptares’ pipeline?
22:45-23:35: Sosei Heptares becoming Nxera
23:35-24:42: Schizophrenia conferences

Interested in being a sponsor of an episode of our podcast? Discover how you can get involved here!

Stay updated by subscribing to our newsletter

فصول

1. New treatments being developed for schizophrenia (00:00:00)

2. What is schizophrenia?  (00:00:57)

3. What are the current schizophrenia treatments?  (00:03:44)

4. Why is schizophrenia challenging to treat?  (00:04:52)

5. Why is 2024 a big year for schizophrenia treatments?  (00:06:27)

6. Seratonin and dopamine modulation  (00:07:34)

7. How does muscarinic modulation work?  (00:08:56)

8. Excitatory and inhibitory tone pipeline (00:10:46)

9. Digital therapeutic and epigenetic modulation  (00:12:35)

10. What are GPR52 agonists? (00:14:12)

11. How are GPR52 agonists different? (00:16:12)

12. Are there lots of schizophrenia treatments coming?  (00:17:53)

13. Will some new schizophrenia treatments be used in conjunction with existing treatments?  (00:19:03)

14. Is a schizophrenia cure possible?  (00:20:10)

15. What will the treatment frequency be? (00:20:49)

16. Where is Sosei Heptares with clinical trials for schizophrenia? (00:21:22)

17. What else is in Sosei Heptares’ pipeline?  (00:22:21)

18. Sosei Heptares becoming Nxera (00:22:45)

19. Schizophrenia conferences (00:23:35)

137 حلقات

#News #Tech News #Labiotech

New treatments being developed for schizophrenia

Beyond Biotech - the podcast from Labiotech

published منذ عام واحد

MP3•منزل الحلقة

It would appear that 2024 is shaping up to be a big year for the development of treatments for schizophrenia, with several clinical trials under way.

Interested in being a sponsor of an episode of our podcast? Discover how you can get involved here!

Stay updated by subscribing to our newsletter

فصول

1. New treatments being developed for schizophrenia (00:00:00)

2. What is schizophrenia?  (00:00:57)

3. What are the current schizophrenia treatments?  (00:03:44)

4. Why is schizophrenia challenging to treat?  (00:04:52)

5. Why is 2024 a big year for schizophrenia treatments?  (00:06:27)

6. Seratonin and dopamine modulation  (00:07:34)

7. How does muscarinic modulation work?  (00:08:56)

8. Excitatory and inhibitory tone pipeline (00:10:46)

9. Digital therapeutic and epigenetic modulation  (00:12:35)

10. What are GPR52 agonists? (00:14:12)

11. How are GPR52 agonists different? (00:16:12)

12. Are there lots of schizophrenia treatments coming?  (00:17:53)

13. Will some new schizophrenia treatments be used in conjunction with existing treatments?  (00:19:03)

14. Is a schizophrenia cure possible?  (00:20:10)

15. What will the treatment frequency be? (00:20:49)

16. Where is Sosei Heptares with clinical trials for schizophrenia? (00:21:22)

17. What else is in Sosei Heptares’ pipeline?  (00:22:21)

18. Sosei Heptares becoming Nxera (00:22:45)

19. Schizophrenia conferences (00:23:35)

137 حلقات

#News #Tech News #Labiotech

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منذ 5 أيام26:42

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منذ 12 يومًا29:56

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منذ 19 يومًا21:24

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منذ 11 weeks39:04

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منذ 12 weeks31:06

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Could antigen modulation address autoimmune diseases? 24:04

منذ 15 weeks24:04

24:04

Immunology is a key area in biotech and biopharma, both in terms of R&D and sales. However, according to UK-headquartered Greywolf Therapeutics, the industry has only focused on two-thirds of the puzzle. To have an immunological effect, you must activate the body’s T cells, which cells requires a chain of three key signals. The first is antigen recognition, i.e. the initial detection of a cell by a T-cell. The second is the co-stimulation of non-antigen presenting molecules, which enhances the immune response. The final step is cytokine-mediated differentiation and expansion, which guides how T-cells target threats. Companies have focused on the second two signals, with signal 2 most commonly seen in therapies such as checkpoint inhibitors and monoclonal antibodies. Signal 3, on the other hand, can be primarily seen in therapies for autoimmune disorders, such as anti-TNF and JAK inhibitors. Greywolf Therapeutics is the first company to explore changing signal 1. The company says focusing on signal 1 applies in three key therapeutic areas: oncology, autoimmunity and virology. Greywolf’s first candidate has delivered strong results during its ongoing phase I/II trial in oncology, therefore demonstrating proof-of-mechanism and target engagement, with its next candidate well-progressed in preclinical development in autoimmunity. To tell us more about the company and its work is Pete Joyce, CEO and co-founder of Greywolf Therapeutics. 01:19-04:12: About Greywolf Therapeutics 04:12-04:51: The origins of the name 04:51-06:52: The three ‘signals’ of the mechanics of immunological responses 06:52-08:31: Treatments associated with each signal 08:31-10:09: Why is step 1 important, and why has it not been investigated for treatments? 10:09-11:28: What areas of disease is this applicable to? 11:28-12:19: How do you inhibit ERAP? 12:19-14:01: Greywolf Therapeutics’ candidates 14:01-15:11: How is this an advance on current treatments? 15:11-16:05: What is success for patients? 16:05-17:20: How does the stage of disease affect treatment? 17:20-18:09: Are other companies looking into antigen modulation? 18:09-19:47: Has this led to investment opportunities? 19:47-21:15: Next steps 21:15-21:55: Do you anticipate more interest in this space? 21:55-23:21: Attending events Interested in being a sponsor of an episode of our podcast? Discover how you can get involved here! Stay updated by subscribing to our newsletter…

1
Beyond profits: The Bill & Melinda Gates MRI's mission to combat neglected diseases 38:10

منذ 16 weeks38:10

38:10

The Bill & Melinda Gates Medical Research Institute (Gates MRI) is a non-profit medical research organization dedicated to the development and effective use of products like drugs, vaccines and monoclonal antibodies to address substantial global health concerns, for which investment incentives are limited, including malaria, tuberculosis, diarrheal diseases, and diseases that impact maternal, newborn, and child health. This week, our guest is Dr Claire Wagner, head of corporate strategy and market access at Gates MRI. Wagner has dedicated her life to global health. Her early years working in West Africa and East Africa – including five years working with the Rwanda Ministry of Health – were formative experiences for her. She helped document health sector outcomes in Rwanda and had a front row seat to the progress the country was making at the time, which led to her pursuing and obtaining an MD and MBA from Harvard. Her experiences led to her becoming one of the early employees of the Gates MRI, where she is on the executive leadership team and leads the institute's global access strategy as well as related engagement with commercial partners, financial institutions and multilaterals. She tackles the challenge of paving the way for the drugs, biologics and vaccines that the Gates MRI is developing – if they are successful in clinical trials – to be affordable and accessible to the people in low- and middle-income countries who would benefit most. In March 2024 the Gates MRI launched a phase 3 clinical trial for a tuberculosis vaccine candidate, and market access for this candidate is a top priority for Wagner. 01:51-04:47: Background on Dr Claire Wagner 04:47-06:24: Work in Rwanda 06:24-08:40: Gates MRI 08:40-12:50: Progress at Gates MRI 12:50-14:06: Gates MRI R&D priorities 14:06-16:26: The differences between Gates MRI and traditional biotechs 16:26-18:40: Gates MRI partnerships 18:40-22:52: The inequality of developing drug treatments 22:52-25:45: Return on investment 25:45-27:01: Did COVID increase global awareness? 27:01-27:44: Other companies working on treatments 27:44-31:48: Gates MRI pipeline and clinical trials 31:48-34:51: Working on tuberculosis 34:51-36:00: Treatment mode of action 36:00-37:25: Future work at Gates MRI Interested in being a sponsor of an episode of our podcast? Discover how you can get involved here! Stay updated by subscribing to our newsletter…

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مشابه لـBeyond Biotech - the podcast from Labiotech

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Beyond Biotech - the podcast from Labiotech « » New treatments being developed for schizophrenia

فصول

1. New treatments being developed for schizophrenia (00:00:00)

2. What is schizophrenia? (00:00:57)

3. What are the current schizophrenia treatments? (00:03:44)

4. Why is schizophrenia challenging to treat? (00:04:52)

5. Why is 2024 a big year for schizophrenia treatments? (00:06:27)

6. Seratonin and dopamine modulation (00:07:34)

7. How does muscarinic modulation work? (00:08:56)

8. Excitatory and inhibitory tone pipeline (00:10:46)

9. Digital therapeutic and epigenetic modulation (00:12:35)

10. What are GPR52 agonists? (00:14:12)

11. How are GPR52 agonists different? (00:16:12)

12. Are there lots of schizophrenia treatments coming? (00:17:53)

13. Will some new schizophrenia treatments be used in conjunction with existing treatments? (00:19:03)

14. Is a schizophrenia cure possible? (00:20:10)

15. What will the treatment frequency be? (00:20:49)

16. Where is Sosei Heptares with clinical trials for schizophrenia? (00:21:22)

17. What else is in Sosei Heptares’ pipeline? (00:22:21)

18. Sosei Heptares becoming Nxera (00:22:45)

19. Schizophrenia conferences (00:23:35)

New treatments being developed for schizophrenia

فصول

1. New treatments being developed for schizophrenia (00:00:00)

2. What is schizophrenia? (00:00:57)

3. What are the current schizophrenia treatments? (00:03:44)

4. Why is schizophrenia challenging to treat? (00:04:52)

5. Why is 2024 a big year for schizophrenia treatments? (00:06:27)

6. Seratonin and dopamine modulation (00:07:34)

7. How does muscarinic modulation work? (00:08:56)

8. Excitatory and inhibitory tone pipeline (00:10:46)

9. Digital therapeutic and epigenetic modulation (00:12:35)

10. What are GPR52 agonists? (00:14:12)

11. How are GPR52 agonists different? (00:16:12)

12. Are there lots of schizophrenia treatments coming? (00:17:53)

13. Will some new schizophrenia treatments be used in conjunction with existing treatments? (00:19:03)

14. Is a schizophrenia cure possible? (00:20:10)

15. What will the treatment frequency be? (00:20:49)

16. Where is Sosei Heptares with clinical trials for schizophrenia? (00:21:22)

17. What else is in Sosei Heptares’ pipeline? (00:22:21)

18. Sosei Heptares becoming Nxera (00:22:45)

19. Schizophrenia conferences (00:23:35)

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مشابه لـBeyond Biotech - the podcast from Labiotech

دليل مرجعي سريع

Beyond Biotech - the podcast from Labiotech « »
New treatments being developed for schizophrenia

2. What is schizophrenia?  (00:00:57)

3. What are the current schizophrenia treatments?  (00:03:44)

4. Why is schizophrenia challenging to treat?  (00:04:52)

5. Why is 2024 a big year for schizophrenia treatments?  (00:06:27)

6. Seratonin and dopamine modulation  (00:07:34)

7. How does muscarinic modulation work?  (00:08:56)

9. Digital therapeutic and epigenetic modulation  (00:12:35)

12. Are there lots of schizophrenia treatments coming?  (00:17:53)

13. Will some new schizophrenia treatments be used in conjunction with existing treatments?  (00:19:03)

14. Is a schizophrenia cure possible?  (00:20:10)

17. What else is in Sosei Heptares’ pipeline?  (00:22:21)

2. What is schizophrenia?  (00:00:57)

3. What are the current schizophrenia treatments?  (00:03:44)

4. Why is schizophrenia challenging to treat?  (00:04:52)

5. Why is 2024 a big year for schizophrenia treatments?  (00:06:27)

6. Seratonin and dopamine modulation  (00:07:34)

7. How does muscarinic modulation work?  (00:08:56)

9. Digital therapeutic and epigenetic modulation  (00:12:35)

12. Are there lots of schizophrenia treatments coming?  (00:17:53)

13. Will some new schizophrenia treatments be used in conjunction with existing treatments?  (00:19:03)

14. Is a schizophrenia cure possible?  (00:20:10)

17. What else is in Sosei Heptares’ pipeline?  (00:22:21)