This Week In Parasitism podcast

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تمت الإضافة منذ قبل ten عام

المحتوى المقدم من Vincent Racaniello. يتم تحميل جميع محتويات البودكاست بما في ذلك الحلقات والرسومات وأوصاف البودكاست وتقديمها مباشرة بواسطة Vincent Racaniello أو شريك منصة البودكاست الخاص بهم. إذا كنت تعتقد أن شخصًا ما يستخدم عملك المحمي بحقوق الطبع والنشر دون إذنك، فيمكنك اتباع العملية الموضحة هنا https://ar.player.fm/legal.

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منذ 1 year57:50

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57:50

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This Week in Parasitism

منزل السلاسل•Feed

TWiP is a monthly netcast about eukaryotic parasites. Vincent Racaniello and Dickson Despommier, science Professors from Columbia University, deconstruct parasites, how they cause illness, and how you can prevent infections.

257 حلقات

#Eukaryotic #Microbiology #Parasitology #Vincent Racaniello #Biology #Science #Natural Sciences #Parasitism

This Week in Parasitism

423 subscribers

updated منذ 14 يومًا

منزل السلاسل•Feed

257 حلقات

#Eukaryotic #Microbiology #Parasitology #Vincent Racaniello #Biology #Science #Natural Sciences #Parasitism

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This Week in Parasitism

1
TWiP 257: Malaya and Malaysia 51:03

منذ 14 يومًا51:03

51:03

TWiP solves the case of the man in the Malaysian city of Kucheng who presents with left arm swelling, and presents a new case for you to decipher. Hosts: Vincent Racaniello , Daniel Griffin , and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Letters read on TWiP 257 New Case We are still in Kuching, Malaysia in the northern part of the Island of Borneo. This is the Sarawak portion of Malaysia. A man in his late 30s is admitted to the hospital in December with daily fevers that last for several hours and shaking chills. He had previously been healthy with no medical problems. He lives in the city and works in an office, however, in the few weeks prior to getting admitted he was visiting the jungle. Apparently not too far outside of Kuching, one can go up into the jungle and see Orangutans. He had gone into the jungle but this was 2 weeks prior to the onset of symptoms. Since then he reports no unusual exposures. He lives with his wife and children and they are all healthy. A few days prior to admission he noted fever, chills, and a headache. He is a little nauseated but no vomiting. On exam he has a fast heart rate and appears ill. His respiratory rate is increased and he is not febrile on admission but later does have fever. No enlargement of the liver or spleen on exam. Otherwise unremarkable. His labs are notable for low white blood cells, anemia, and a platelet count of less than 50k per microL. His coagulation studies are abnormal, serum creatinine is elevated, and there is elevation of his serum aminotransferases. Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees…

This Week in Parasitism

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TWiP 256: Amazing antimalarial drug resistance 1:02:55

منذ 29 يومًا1:02:55

1:02:55

TWiP explains a study that carries out selection of Plasmodium falciparum in the presence of inhibitors to identify determinants of drug resistance, and a paleoparasitological analysis of a 5th–16th c. CE latrine. Hosts: Vincent Racaniello , Daniel Griffin , and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Naegleria fowleri acquired at splash pad (MMWR) Determinants of P. falciparum drug resistance (Science) Paleoparasitological analysis of 5th–16th c. CE latrine (Parasitol) Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees…

This Week in Parasitism

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TWiP 255: Katayama fever 56:45

منذ 6 weeks56:45

56:45

Michelle Labrunda joins TWiP to solve the case of the Georgian in Guinea with fever and dry cough, and describe a new case for you to solve. Hosts: Vincent Racaniello , Daniel Griffin , and Christina Naula Guest: Michelle Labrunda Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Letters read on TWiP 255 New Case A man who is on eculizumab, a recombinant humanized monoclonal antibody that targets complement protein C5 which serves as a terminal complement inhibitor, comes in with left arm swelling. He lives in a city in the north part of the island of Borneo. He is being managed by a doctor in the Malaysian City of Kuching. Now the doctor caring for this man is married to an Infectious Disease expert and she raises concerns that this might be due to a parasitic disease. She is told by the husband that the disease of which she is thinking is not present in the region. She is not swayed and admits him for nightly blood smears which are negative. She then does a rapid immunochromatographic dipstick test that is positive. He lives in a community outside the city and they go to that village and find others with limb swelling issues who are also positive on antigen testing. He is treated with an antibiotic, not antiparasitic for 4 weeks and the arm improves. Hint: this is not Wuchereria Bancrofti . Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees…

This Week in Parasitism

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TWiP 254: Our hero Dickson 1:00:47

منذ 8 weeks1:00:47

1:00:47

TWiP explains a study which finds that tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei, then remembers our departed colleague Dickson Despommier. Hosts: Vincent Racaniello , Daniel Griffin , and Christina Naula Click arrow to play Download TWiP #254 (88 MB .mp3, 61 minutes) Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Tissue spaces are reservoirs of antigenic diversity for T. brucei (Nature) Understanding trypanosome antigenic variation (Emerg Top Life Sci) Tissue resident T. brucei (PLoS Path) Hero – Dickson Despommier Despommier Photo Art Parasitology Course (YouTube) Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees TWiP explains a study which finds that tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei, then remembers our departed colleague Dickson Despommier. Hosts: Vincent Racaniello , Daniel Griffin , and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Tissue spaces are reservoirs of antigenic diversity for T. brucei (Nature) Understanding trypanosome antigenic variation (Emerg Top Life Sci) Tissue resident T. brucei (PLoS Path) Hero – Dickson Despommier Despommier Photo Art Parasitology Course (YouTube) Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees…

This Week in Parasitism

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TWiP 253: Sub-Saharan somnolence 1:01:47

منذ 10 weeks1:01:47

1:01:47

TWiP solves the case of the man with somnolence and something extra-erythrocytic, and presents a new puzzle for you to solve. Hosts: Vincent Racaniello , Daniel Griffin , and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Letters read on TWiP 253 New Case 26-year-old female with no past medical history. Patient is from Georgia in the US and is volunteering in Hérico, Guinea (town in the Lélouma Prefecture in the Labé Region of northern-central Guinea). She arrived in Guinea in December 2023. She was taking doxycycline for malaria prophylaxis and says that she has not missed any doses On October 2024 she presented with fever and dry cough. Lab work was done and follow up planned for the following day. The patient slept poorly, was febrile to 104 and had ongoing cough. The next day she went to the hospital and was evaluated in the ER for acute febrile illness of unclear etiology. In the hospital, VS were 97.9F, BP 105/70, P 94 Oxy sat 98%, normal physical exam. She was started on Augmentin and Coartem. Pause here to think about the differential at this point and maybe some more history and what testing you might want WBC 14, Hb 13, HCT 40, PLT 285, Neut abs 8, Eos Abso0.80; BUN/creat normal, AST normal; ALT 44, GGT 125 Stool parasite screen + for some sort of eggs, malaria smear negative, CXR with b/l infiltrates She was given a medication (vomited 30 min after dose received). She then received a second dose of medication 5 hours after the first) and was discharged. The following day the patient returned to the ER, stating that she felt worse. Her temperature had climbed to 104 overnight, and she developed watery diarrhea and nausea. There were no additional episodes of vomiting. She was given an additional dose of a medication, ibuprofen, and started on ceftriaxone 1 gm IV Q12 hrs. During the day she continued to have low grade fevers and developed abdominal pain. That night she was again febrile to 104 F. She remained admitted for 5 days with ongoing symptoms of diarrhea, nighttime fevers and diffuse abdominal discomfort. Three more malaria tests were negative (rapid test and slide review) Blood cultures collected – no growth She continued to have mild elevation of WBC and slight elevation of AST and ALT. The patient was transferred to a different hospital. They give her a different medication, and within 24 hours symptoms resolve. What is the diagnosis and what happened here with management? Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees…

This Week in Parasitism

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TWiP 252: For malaria vaccine, mosquito is the needle 54:27

منذ 12 weeks54:27

54:27

TWiP discusses a study of the safety and immunogenicity of a late liver-stage attenuated malaria parasite delivered by mosquito bite. Hosts: Vincent Racaniello , Daniel Griffin , and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Live attenuated malaria vaccine (NEJM) Plasmodium metabolism during hepatic development (Cell) Heroes – Jimmy and Rosallyn Carter , and the Carter Center The Carter Center Guinea Worm Eradication Programme Guinea Worm data visualisations (Our World in Data) Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees…

This Week in Parasitism

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TWiP 251: Case of the facial ulcer 57:29

منذ 15 weeks57:29

57:29

TWiP solves the case of the woman who went to Belize and notices a lesion on her face, and presents a new clinical case for you to solve. Hosts: Vincent Racaniello , Daniel Griffin , and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Letters read on TWiP 251 New Case Recent case, Arusha hospital, 1800 m, 28 yo comes in, has been visiting game parks. Developing fevers, malaise, bad headaches, body aches, somnolent. Blood smears negative, no malaria. Repeat blood smear, see something extra-erythrocytic. This gives them the diagnosis. HIV neg, no toxic habits, no history. Symptom onset about a week ago. Rest of family is ok. Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees…

This Week in Parasitism

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TWiP 250: Gut bacteria help Trichinella suppress colitis 51:46

منذ 17 weeks51:46

51:46

TWiP reviews a study showing that the gut microbiota is essential for suppression of colitis by Trichinella spiralis . Hosts: Vincent Racaniello , Daniel Griffin , and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Gut bacteria and Trichinella suppression of colitis (PLoS NTD) Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees…

This Week in Parasitism

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TWiP 249: A virus and a parasite 55:48

منذ 19 weeks55:48

55:48

TWiP solves the case of the middle-aged man with eosinophilia and a history of sexual activity with paid sex workers in Okinawa, and presents a new case for you to solve. Hosts: Vincent Racaniello , Daniel Griffin , and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Letters read on TWiP 249 New Case Woman in 30s or 40s goes to Belize and after returning notices a lesion on her face. She goes to see several physicians and despite a number of topical creams the ulcer on her face does not heal. She is then referred to our office where a certain parasitic infection is considered and we involve our friends at Columbia to help us with the diagnosis.. Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees…

This Week in Parasitism

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TWiP 248: Toxoplasma reduces Alzheimer's disease 1:06:59

منذ 21 weeks1:06:59

1:06:59

TWiP reviews the observation that infection of Azlheimer’s disease mice with Toxoplasma gondii reduces brain amyloid density globally and regionally. Hosts: Vincent Racaniello , Dickson Despommier , Daniel Griffin , and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Toxoplasma reduces amyloid in brain (J Inf Dis) Hero: Theodor Hiepe (Parasitol Res) Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees…

This Week in Parasitism

1
TWiP 247: Manhattan mystery malady 58:29

منذ 24 weeks58:29

58:29

TWiP solves the case of the Manhattan man with pain on urination or ejaculation, and presents a new case for you to solve. Hosts: Vincent Racaniello , Dickson Despommier , Daniel Griffin , and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Hero: Charles Louis Alphonse Laveran Letters read on TWiP 247 New Case A middle-aged male is referred to evaluation because of eosinophilia. This man is married, living here in the NY tristate area, and this was picked up on ‘routine blood work’ by his primary care doctor. This man had been in the military, serving as a marine, with time spent in Okinawa, Japan. This individual does report sexual activity with paid sex workers while in Okinawa but has been monogamous with his current wife for many years. A number of investigations are done with a test coming back showing serological evidence of a prior parasitic infection and he was treated with an antiparasitic medicine with resolution of the eosinophilia. The eosinophilia returned and he was referred to us. Blood work is now down showing evidence of a viral infection that might explain why the eosinophilia returned after treatment. Pt is HIV negative. This was prior to the COVID-19 pandemic. He is on no medications and in general feels fine. Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees…

This Week in Parasitism

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TWiP 246: Everything spiral: a worm in a hurry 1:23:52

منذ 26 weeks1:23:52

1:23:52

TWiP taps into Dickson’s knowledge of Trichinella to discuss an outbreak in humans who consumed rare bear meat, and the impact of globalization and climate change on the epidemiology of the species. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Outbreak of human trichinellosis (CCDR) Impact of climate change on Trichinella (Food Waterborne Parasit) Letters read on TWiP 246 Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees…

This Week in Parasitism

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TWiP 245: Flying purple people eater with Ben LaBrot 1:16:22

منذ 28 weeks1:16:22

1:16:22

Founder of Floating Doctors Ben LaBrot joins TWiP to solve the case of the 1 year old in northeastern Panama with a fatal leg infection, followed by a discussion of the history and mission of Floating Doctors. Hosts: Vincent Racaniello , Daniel Griffin , and Christina Naula Guest: Ben LaBrot Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Floating Doctors Letters read on TWiP 245 New Case A man in his early 20s comes in reporting pain when he urinates or ejaculates. He reports that he is sexually active. He does confide that he has been in a relationship with a woman but he had a sexual encounter outside this relationship about 2 weeks ago when they were on a break and he did not wear protection. He feels like he needs to urinate more often and describes thin white discharge from the penis. He reports that he has no history of any sexually transmitted infections and had no medical issues prior to this. Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees…

This Week in Parasitism

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TWiP 244: Engineering Toxoplasma 49:41

منذ 30 weeks49:41

49:41

Lilach Sheiner joins TWiP to talk about her career and her work on engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons. Hosts: Vincent Racaniello , Dickson Despommier , and Christina Naula Guest: Lilach Sheiner Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Engineering T. gondii for protein secretion (Nat Micro) Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees…

This Week in Parasitism

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TWiP 243: Don't blame it on Mexico 1:06:23

منذ 32 weeks1:06:23

1:06:23

TWiP solves the case of the Woman with White Worms, and submits a new case involving a 1 year old in northeastern Panama with a fatal leg infection. Hosts: Vincent Racaniello , Dickson Despommier , Daniel Griffin , and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Enterobius, the pinworm ( TWiP 19 ) Hero: Mary Pritchard New Case This case comes from Panama mid summer 2024. A provider for Floating Doctors working in the coastal region in northeastern Panama. This case involves a one year old, so the history is a bit difficult, but there may have initially been a scratch or some sort of break in the skin. Otherwise healthy but over a period of time this area expands and becomes a deep necrotic wound on the leg. Several other nearby wounds develop and become deep and infected. By the time this one year old is seen by the provider much of the leg appears eaten away. This is just the tip of the iceberg as a number of others develop similar wounds in the area. No prior medical history. Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees…

مرحبًا بك في مشغل أف ام!

يقوم برنامج مشغل أف أم بمسح الويب للحصول على بودكاست عالية الجودة لتستمتع بها الآن. إنه أفضل تطبيق بودكاست ويعمل على أجهزة اندرويد والأيفون والويب. قم بالتسجيل لمزامنة الاشتراكات عبر الأجهزة.