Can AI compress the years long research time of a PhD into seconds? Research scientist Max Jaderberg explores how “AI analogs” simulate real-world lab work with staggering speed and scale, unlocking new insights on protein folding and drug discovery. Drawing on his experience working on Isomorphic Labs' and Google DeepMind's AlphaFold 3 — an AI model for predicting the structure of molecules — Jaderberg explains how this new technology frees up researchers' time and resources to better understand the real, messy world and tackle the next frontiers of science, medicine and more. Want to help shape TED's shows going forward? Fill out our survey ! For a chance to give your own TED Talk, fill out the Idea Search Application: ted.com/ideasearch . Interested in learning more about upcoming TED events? Follow these links: TEDNext: ted.com/futureyou TEDAI Vienna: ted.com/ai-vienna Hosted on Acast. See acast.com/privacy for more information.…
Hosted by David Pfalzgraf, the managing partner of the law firm Rupp Pfalzgraf, LLC, Empire State Entrepreneurs is a fun and informative venue to feature clients, strategic partners, community leaders, and team members to talk about relevant issues for entrepreneurs and business owners throughout New York State. Guests of the podcast offer dynamic insight into the many stages of business ownership, along with opportunities to understand the legal issues surrounding entrepreneurship in NYS.
Hosted by David Pfalzgraf, the managing partner of the law firm Rupp Pfalzgraf, LLC, Empire State Entrepreneurs is a fun and informative venue to feature clients, strategic partners, community leaders, and team members to talk about relevant issues for entrepreneurs and business owners throughout New York State. Guests of the podcast offer dynamic insight into the many stages of business ownership, along with opportunities to understand the legal issues surrounding entrepreneurship in NYS.
In this heartfelt and inspiring episode, host David Pfalzgraf welcomes his lifelong friend, creative force, and Buffalo native Pete McGennis . From childhood memories in Buffalo to the creation of Harley-Davidson’s only co-branded product, and now seven feature films and counting, Pete’s journey is a masterclass in resilience, storytelling, and following your joy. They reflect on Pete’s early entrepreneurial adventures, including building a national brand (Cool Sack), and dive deep into his evolution as a filmmaker and creative entrepreneur. Along the way, Pete shares life lessons on adversity, creative risk, community-building, and why time - and joy - are the most valuable currencies. Episode Highlights: Pete and David's lifelong friendship, growing up in Buffalo How childhood creativity and sports laid the foundation for storytelling From college theater to summers in LA, and a return to Buffalo with new perspective The birth of “Cool Sack,” transforming a family idea into a Harley-Davidson success story Lessons from 14 years working with Harley, manufacturing locally, and facing a corporate pivot How losing the Harley contract sparked Pete’s full leap into filmmaking The bold decision to shoot a feature film in New Orleans and the fear, risk, and joy that came with it Telling Buffalo’s stories: Crystal Beach, Queen City, and Bubble Girl Why storytelling is a service, and how Pete helps businesses share their purpose through music and film Sneak peek into his new film St. Peter Street , a Buffalo–New Orleans musical comedy Reflections on creative purpose, time as currency, and building a life centered on joy Pete’s next dream: a solo album, new films, and helping others find purpose through story Key Takeaways: Adversity often hides opportunity. Pete’s biggest creative breakthroughs came after career challenges. Joy is the compass. Whether creating for film, business, or music, Pete’s north star is always joy and connection. Time is currency. Choose wisely where your energy goes - it’s your greatest creative asset. Buffalo is a muse. From storytelling to location filming, the Queen City is deeply embedded in Pete’s work and identity.…
Brian Higgins has been a mainstay in Buffalo for decades. Even in his time in state and federal government, he was fighting to give Western New York the best opportunities to thrive. Now, as CEO and president of Shea's Performing Arts Center, the former congressperson comes back home to serve the community through the arts. Listen as Brian takes Dave from his humble beginnings in South Buffalo all the way to the nation's capital, and back again. Brian Higgins' Early Life and Education Born and raised in South Buffalo , the second youngest of five. Father: Union bricklayer and Buffalo City Council member (1969–1978); Mother: Grammar school teacher. Earned both undergraduate and graduate degrees from Buffalo State College . Attended Harvard University for a Master’s in Administration and Policy in 1996— funded by a fellowship endowed by Bob Wilmers (former M&T Bank CEO) after Higgins initially deferred due to cost. Political Career Highlights Elected to Buffalo City Council at age 25, then to the New York State Assembly , and later to the U.S. House of Representatives (2004–2023). Focused on transforming Buffalo rather than seeking national impact. Major legislative victory: $300 million settlement from the New York Power Authority used to redevelop Buffalo’s waterfront—leveraged during the relicensing of the Niagara Power Project. Advocated for and helped shape federal and state historic tax credits , instrumental in Buffalo’s downtown renaissance. Leadership at Shea’s Performing Arts Center Took over as CEO in 2023, seeing Shea’s as both a cultural treasure and an economic catalyst for downtown Buffalo. Announced an ambitious $60 million capital improvement plan , including: $15M expansion to improve traffic flow and facilities Renovations at 710 Main and Shea’s Smith Theaters Development of artist lofts and digital signage across the theater district Stressed the economic multiplier effect of shows like The Lion King , which brought 68,000 attendees and $19 million in local spending. Revitalizing Downtown Buffalo Emphasized Shea’s role in revitalizing the theater district as a vibrant, 24/7 destination. Working with local businesses, architects, and government to blend art, culture, and urban development. Plans include improved streetscapes, lighting, signage, and pedestrian engagement—drawing parallels to Times Square. Reflections on Congress and Transition to Local Leadership Candid critique of Congressional dysfunction , citing gridlock, government shutdown threats, and wasted potential. Felt constrained as one of 435 in Congress; sought a more direct and tangible local impact . Now finds fulfillment in community-based leadership , where incremental progress is more achievable and visible. Personal Values and Community Vision Strong ties to Buffalo’s neighborhoods and appreciation for its historical assets. Advocates for inclusive economic growth across all Buffalo communities. Inspired by Michael Shea’s original mission —creating accessible entertainment for working people. Describes himself as more introverted than most expect and passionate about world history and service . Teased a possible future book based on reflections from visits to nearly 100 countries during his congressional service. Call to Action for the Business Community Encourages business leaders to engage with Shea’s capital campaign. Opportunities include naming rights and other contributions to support Shea’s as a pillar of Buffalo’s cultural and economic life. Reinforces that Shea’s is community-owned and its stewardship is a collective responsibility.…
The science of sound is a unique and interesting area of study. Ultimately, we can attribute everything we hear to vibration. But not every vibration is a good vibration, and that's where Mike Latvis of Harmonic Resolution Systems comes in. From humble beginnings in aerospace to turning his passion for a pristine listening experience into a career, Mike takes Dave through his journey in music and science. Highlights of the episode include: From Basement Hobbyist to Global Audio Brand Mike shares how his teenage obsession with music and turntables led him to engineer audio systems in his parents’ house — literally hanging gear from the ceiling to avoid skips. His journey from those early DIY setups to founding Harmonic Resolution Systems is a masterclass in passion-meets-preparation. Engineering Meets Entrepreneurship A lifelong mechanical engineer, Mike discusses how 15+ years of experience in vibration and noise control across the nuclear and aerospace industries laid the technical groundwork for HRS. His decision to start his company was fueled not just by opportunity but a desire for long-term control over his career and legacy. Five Years, Two Jobs, One Dream Listeners will be inspired by Mike’s grit: for five years, he ran HRS on nights and weekends while still working full-time. He shares the realities of launching a high-end product, convincing his wife, children, and customers one step at a time that his vision could succeed. Finding the Aha Moment The big break came when Mike recognized a market gap — high-end audio furniture wasn't engineered to match the sophistication of modern audio components. That insight became the foundation of HRS, blending aerospace-grade isolation systems with the art of sound. A Global Brand, Built in Buffalo Today, HRS is distributed in over 40 countries and used in elite systems around the world. From collaborations with Fender and Mobile Fidelity , to systems costing well into six figures, Mike walks us through HRS’s ascent as a globally recognized name in audio excellence. Powered by People Mike emphasizes the critical role of people — from engineers to lawyers and vendors — in growing a company. He reflects on the ecosystem of support in Western New York , crediting partners like Rupp Pfalzgraf for playing pivotal roles in HRS’s survival and success. Giving Back: From Grief to Legacy In an emotional turn, Mike recounts how the loss of his wife Jodi to ovarian cancer spurred the creation of the Jodi V. Lava Ovarian Cancer Research Fund at Roswell Park . Now, he’s using HRS’s global reach to host music-driven fundraising events — most recently with the Lumineers in Brooklyn — to support cancer research and community initiatives. What’s Next for HRS? Even as a leader in his industry, Mike refuses to rest. New product launches, constant R&D, and a mission to give back are at the core of what keeps HRS evolving. “If you don’t replace yourself,” he says, “someone else will.”…
Tony Rupp may be a man who requires no introduction, as the founding partner of the law firm Rupp Pfalzgraf, LLC. Tony joins host Dave Pfalzgraf and longtime friend and partner in tech, Steve Poland for a forward-thinking episode of Empire State Entrepreneurs. Topics on this episode include the many uses of AI in the practice of law, the origins of Go To Verdict , and solid advice for entrepreneurs and startups. Origin Stories : Steve and Tony reflect on growing up in the Buffalo area and their early interests in programming and entrepreneurship. How a mutual appreciation for technology sparked their collaboration. The Founding of Rupp Pfalzgraf : Tony’s leap from big law to co-founding an agile, tech-forward firm. Using emerging tech to reimagine law firm operations and client service. Go To Verdict: Revolutionizing Jury Selection The creation of a proprietary jury selection software using public records and automation. Real-time, AI-assisted juror profiling that gives attorneys a competitive edge. Automated reporting features that save time and impress clients. Oxford Knox & Judgment Recovery Innovation : A tech solution for identifying collectible judgments across NYS using scraped public data. How the system uses Go To Verdict's backend to assess debtor asset information at scale. Lead Gen: Tech-Enabled Legal Marketing Leveraging public databases to identify legal needs and ethically reach potential clients. How Rupp Pfalzgraf personalizes marketing through automation and compliance. The Power and Future of AI in Law : Why Tony and Steve believe AI will transform the legal profession—not replace it. Practical ways the firm already integrates AI into research, document drafting, and case prep. Advice for Entrepreneurs : “Sell it before you build it” – Steve’s lean startup insight. Tony's tip: Always ask whether AI can help before starting a task. What’s Next? 30+ tech projects in development, from document automation to AI-driven legal research. A glimpse at future plans to modernize and scale law through innovation. Personal Nuggets : Steve’s passion for fantasy football and tech experimentation. Tony once watched a George Foreman fight with a young Senator Joe Biden at Cornell!…
There is something to be said about accountability, a support network, and discipline. For Nick Ennis and Max Montante , it's given them the opportunity to give back with Mind Over Foundation . In this episode, host Dave Pfalzgraf speaks with Nick and Max about their dedication to mental wellness, and how their life experiences set the groundwork for their cause. Highlights include: - Growing up in WNY - Lifelong friendships - Joining the family business - Perpetuate the family legacy - Learning to share insights - Dealing with intense tragedy - Finding your passion - The significance of family support - A unique way to network - Building toward big goals - Developing a community - Leaning into your support network - The power of journaling - Deciding to make a difference - The Mind Over journey - Sharing the tools learned in past experiences - The impact of shared motivation - Perspective alters understanding - Reach out on the Mind Over website - Connecting on social media - The evolution of the significance of addressing mental wellness - Turning personal needs into motivation to help others - The small things that make a big impact - Consistency as an indicator of success - Progress takes patience - Always wear a helmet…
Dr. Leonard Kaplan has spent decades studying wellness and has built a practice that incorporates integrative, regenerative, and functional medicine into the treatment of the patients at OWM Integrative Wellness . Host David Pfalzgraf and Dr. Kaplan explore a life dedicated to developing an understanding of the human body and its systems, the future of medicine, and more. Highlights include: - Following in dad's footsteps - Having an early idea of what the future might hold - Choosing osteopathy over traditional medicine - Why Chicago? - Military service and medicine - Deciding between Walter Reed and Madigan - Buffalo Spine and Sports Medicine - Falling in love with Buffalo - Struggling to balance insurance reimbursement processes and patient care - The significance of forming a relationship with patients - Removing insurance as an obstacle to care - Becoming comfortable with being uncomfortable - Manifesting (AKA: Making it Happen) - Starting an integrative medicine practice - Developing a passion for serving like-minded people - The independent spirit and building equity - Having faith in the practice - Finding the right space - The intrinsic drive to never quit - Stewarding Buffalo's history - Cultivating resources for continued learning - A healing environment to heal a body - Preparing against disease - Obtaining superior outcomes through cooperative care - Providing techniques that aid everyone from young athletes to the elderly - The Recovery Lounge, and what the future holds - Not accepting the no - Finding pure joy outdoors…
If you are in Buffalo and you like craft beer and great food, chances are you've been to a Schutte Hospitality restaurant. Managing Creekview , Britesmith Brewing , Oliver's , and Marcato is no easy task, but David Schutte's labors of love have been providing Western New York with excellent experiences all over the region. Learn more about David and the path to hospitality on this episode of Empire State Entrepreneurs: NY Business Law. Highlights include: - Getting an early start in hospitality - Experiencing NYC - The Rainbow Room - Learning a true commitment to quality and hospitality - Michelin stars - Coming home to build a life - Opening Babaloo, preceding Fat Bob's - Turning the experience into ownership of Creekview - Putting in the hours - Preserving quality by owning processes from start to finish - Purchasing Buffalo's Top Restaurant - The importance of the chef team and their creativity - Breaking into the brewery sector - Adding a new location for Britesmith on Niagara Street - Marrying the best parts of each location - Building an exemplary executive team - Experiencing everything travel has to offer…
In a landscape dominated by chain grocery stores, Stuart Green operates Braymiller Market , which proudly provides fresh produce and tantalizing prepared foods for the southtowns, and as of 2020, downtown Buffalo. In Episode 8 of the Empire State Entrepreneurs podcast, we learn Stuart's story. Highlights include: - A photographic beginning - An unlikely first career - An unlikely second career - Purchasing a local legacy - Going from a corporate industry to owning a small business - The Undercover Boss theory - Learning to work with someone who is rooted in your new acquisition - Early changes - The wholistic approach to providing food to a region - Finding creative ways to save and cut back on waste - Launching a new location and how plans change - How self-reflection drives decision making - Maximizing traffic to a location during a lockdown - Working with the development team, and managing building ownership - Passing the torch to the next generation - Giving the people what they want - Supporting local business - Competing with bigger chains - Growing against the grain - The physical and financial investment that makes entrepreneurship rewarding - Mr. Fixit…
Evan Giokas and Carl (CJ) Montante III bring an immeasurable wealth of energy to every room they are in. They are experts in communication, and that's clear from the moment they begin a conversation. This episode of Empire State Entrepreneurs is no exception - the great minds behind MGM Coaching take Dave through a journey of self-discovery and give listeners a chance to evaluate how they communicate, and how to improve interpersonal relationships by simply understanding themselves. Highlights include: - Starting as the College Confidence Coach - Bad golf and good times - Networking poorly - Overcoming the resistance to change - Utilizing the cognitive profile - Breaking away from the family business - Campus Solutions and the entrepreneurial spark - Original applications for cognation - The flaws in the varied approaches to personality assessments - In sync vs In strain - Understanding who you're not is as important as understanding who you are - How personal partnerships operate like business partnerships - The significance of understanding what environment brings out the best in your employees - What leads to burnout and how to prevent it - Repeatable, scalable, franchisable - How to get to the next level - what motivates you to take the next step? - Give first vs take first - The art of conversation - Five gives before an ask - Creating value in relationships - Surprising predictors and leadership retreats…
One thing is certain: Buffalo is lucky to have Nagendra Raina . His journey to becoming the president of Buffalo Games is a story for the ages, and he shares that exciting odyssey with us here in Episode 7. Highlights include: - Growing up in New Delhi - Losing a parent at a young age - Using loss to build resilience and courage - Math, Science, and Programming - Growing from a coder to an entrepreneur - Coming to America (and not Canada) - Growing from an entrepreneur to president of the fastest growing toy company in America - Managing a national brand with offices located internationally - The eerie quiet of American cities - Working through the stress of traveling as high-level management - The new vision for Buffalo Games - The need to attract talent and energize a team - Leveraging technology to stay on top of trends - The importance of investing in market research - High quality, low cost manufacturing domestically - Assembling the best team - Investing time into attracting and maintaining talent - Battling the negative rhetoric surrounding Private Equity - Balancing decisions on acquisitions with business growth - What direction will Buffalo Games take in the next five years? - Grow fast; grow fairly - Smell the roses when you can - You can solve a process problem with the right people, but you can never solve a people problem with a process…
As the Chief Information Officer for M&T Bank , Mike Wisler has been to every corner of the Western world, but found answers a lot of the questions that life had raised along the way in the unlikeliest of places. Highlights of the conversation include: - Bringing Middle Ohio to Buffalo - A startup that became an international enterprise - Modernizing statistical analysis - The problematic lifestyle of a traveling manager - Listening to the voice inside your head - Finding Buffalo; finding reason - The significance and impact of community action, and how Buffalo excels at it - The importance of technology and innovation for a community - Adopting a reverence for contemporary business approaches - Searching for problems to solve - Signaling to the country - and the world - that Buffalo is a leader in technology and innovation - Collaborative Clustering - Belief, Behavior, Technique - Garnering trust within a workplace - Connecting the Waterfront with the Medical Campus - Recognizing when lightning will strike - Kickstarting 43 North and where it stands a decade later - Maniacal focus - The path of the ultra-successful - "Leadership is an endurance sport."…
Jamie Obletz took a position at Delaware North just as business in that industry was coming to a screeching halt. On this episode of Empire State Entrepreneurs, Jamie and Dave discusses how he dealt with the adversity and ushered the Sportservice division to new heights. Highlights include: Heading to NYC for grad school Working at J.P. Morgan The marathon weeks of investment banking Advocating for yourself (Taking matters into your own hands) The Risk Journey Turning relationships into opportunities Coming home and starting new The value of establishing your value Holistic leadership Translating investment to growth Transitioning from silos Taking on an onslaught of challenges, and the relative reward Getting creative in tumultuous times Existing at the forefront of innovation Developing strength of culture The flexibility of private ownership and competing on an international stage The significance of corporate citizenship Always be learning Change Agenda Going from the highest of highs, to the lowest of lows, and then back up to the top Fun with islands…
On this episode, host Dave Pfalzgraf welcomes Sharon Cryan , The creative, motivated mind behind FoodNerd . The revolutionary snack products at FoodNerd offer children a full compliment of key nutrients, supporting healthy habits at a young age. "We're on a mission to redefine what kids eat today, tomorrow, and in the future. We craft a variety of tasty foods, but beneath the deliciousness, we're also setting new standards for nutrient density," Sharon writes. Tune in for Sharon's story, and how a shift in focus can help your child - and even you! realign your journey to healthy eating. Highlights include: - The impact of nutrition on overall health, and learning through the stages of life - Growing up in the food production and distribution area of Buffalo - Identifying her future path at a young age - Making connections via the crossover between law studies and politics - Creating a voice for the voiceless - Where 'Food Nerd' came from, and the joy it brought - Redefining the lunchbox - The influence of Japanese culture and the approach to nutrition - Turning meal prep into an income source - Self love through nutrition - Repositioning to keep the product affordable - Turning client feedback into positive change - Happy accidents - How processing damages nutrition in foods - The future of product development - Optimizing nutrition while remaining convenient - Standing out from standard Buffalo Food Manufacturing - Utilizing university science and research to help product development - #FoodTruth - Scalability and disrupting the industry - Impactful advice for small businesses and entrepreneurs…
Frank Ewing is the CEO of AML Rightsource , a global leader in financial crime prevention and third-party compliance. According to their website, Frank is, "...a thought leader and innovator in the global anti-financial crimes and regulatory management space and is always focused on providing the best service and experience for our clients." Listeners will soon learn that his focus on service for both his internal and external clients is what drives him to be the best leader he can be. In this episode, host David Pfalzgraf takes a swift journey with Frank, discussing his upbringing in upstate New York, his journey to settling in Buffalo, and how he got started in the industry. Highlights include: - Thursday in the Square - Giving small community banks the same access to anti-financial crime platforms as the larger national banks - Launching AML with partners in Cleveland - Crossing paths with Rupp Pfalzgraf - The decision to attend Law School at University at Buffalo - How his education informed his approach as a leader - Terms of endearment - Applying his overall experience to working with M&T Bank - How Buffalo became the home of AML Rightsource - The amount of money tied to financial crimes - Technology: enabler or disruptor? - The power of focused training - Coming full-circle - Buffalo as a technology hub - The rugged, industrious draw of the city - What's next for AML, and how that ties into what's next for the community - What can we do to keep the young, motivated workforce in Buffalo? - Advice for fellow entrepreneurs - The value of empathy…
Juweria Dahir is a gift to the Buffalo entrepreneur community. She has developed a passion for data, evidence-based decision making, and listening, and has applied that passion to improve access to crucial networking opportunities for small businesses in underserved populations as the Director of Director of Innovation and Entrepreneurship at the Buffalo Niagara Medical Campus . In this episode, host Dave Pfalzgraf leads Juweria through a journey that begins with her early life and how her humble upbringing prepared her to be an advocate for the communities she works ceaselessly to service. Highlights include: - Farming in Switzerland - Finding a home in Buffalo - Teaching the world the difference between New York and New York - Building relationships, Glee, and learning American humor - Finding that accents are nearly a language barrier - The technological lag in America right now - Thought partners and change agents driving progress - Racial divisions vs class divisions - The Urban Fellow Program in the City of Buffalo - Priority mechanisms and the importance of maintaining public services in distressed neighborhoods - The significance of listening in leadership - Use of the Open Data Portal, sponsored by Bloomberg, along with Harvard and Johns Hopkins - Innovation in city government - Working with Matt Enstice at BNMC - The challenges of guiding businesses through reopening after COVID - Helping marginalized individuals learn to build wealth through entrepreneurship - Fostering relationships and developing crucial networking opportunities for business - Partnering with Josh Roetzer , Associate Attorney at Rupp Pfalzgraf - The best Chicken and Waffles in Buffalo! - The significance of being flexible as a business owner - Approaching everything with a coachable mindset…
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