An ideal opportunity for those interested in addiction medicine to get a closer look at the perspectives behind formal research articles. Podcasts offer insights into the experiences of the authors and researchers behind the great work and development in the field. Listening to their stories and thought processes helps listeners to connect with the experts behind the journal in a brand-new way. Hosted by Journal Podcast Editor, Shawn McNeil, MD
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Hey science nerds! Welcome to Beyond the Abstract, a science podcast dedicated to discussion of the coolest cutting edge, basic science research papers in a way that just about anyone can understand. We're your hosts, Derek, Dan, and Ellen, three MD/PhD students coming from the University of Pennsylvania and Harvard Medical School who are passionate about science communication and bridging the gap between science and medicine. In each episode, we’ll dive into a paper and talk about the exper ...
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Integration of a Community Opioid Treatment Program Into a Federally Qualified Health Center
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14:02In this episode, Dr. Christine Neeb sits down to discuss integrated treatment programs and how this model could potentially be adapted to other populations with SUD. Dr. Neeb is a Visiting Associate Professor and the Director of Integrated Primary Care and Addiction in the Division of General Internal Medicine at the University of Colorado Anschutz…
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Plaque Hacks: When it Comes to Statins, Consistency is Key
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16:29Cardiovascular disease is the leading cause of global mortality. Among the many risk factors for cardiovascular disease, it's long been known that high cholesterol increases the risk for heart attacks and stroke. In today's episode of Beyond the Abstract, Derek and Dan discuss two new papers that challenge commonly held beliefs about the way in whi…
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Expert Panel Consensus of the Effectiveness and Implementation of Models to Support Posthospitalization Care Transitions for People With Substance Use Disorders
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22:44Podcast host Shawn McNiel, MD, is joined by Michael Incze, MD, MSEd to discuss his new article Expert Panel Consensus of the Effectiveness and Implementation of Models to Support Posthospitalization Care Transitions for People With Substance Use Disorders which aimed to establish a hierarchy of existing SUD care transition models in 2 categories-ef…
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The Efficacy of GLP-1 Agonists in Treating Substance Use Disorder in Patients
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23:48In this episode of Beyond The Abstract, Dr. Joji Suzuki stops by the show to discuss his recent co-authored review on GLP-1 agonists and their potential role in addiction treatment. Dr. Suzuki is the founding Director of the Division of Addiction Psychiatry in the Department of Psychiatry, Brigham and Women’s Hospital (BWH), and an Associate Profes…
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Higher First 30-Day Dose of Buprenorphine for Opioid Use Disorder Treatment Is Associated With Decreased Mortality
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20:04Host Shawn McNeil, MD, is joined by Michelle Lofwall, MD, DFAPA, DFASAM, a professor in the Department of Behavioral Science and Psychiatry at the University of Kentucky and Medical Director of UK’s Robert Straus and First Bridge Clinics, which provide comprehensive OUD treatment within the UK Center on Drug and Alcohol Research. Dr. Lofwall and he…
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Chasing The Fountain of Youth: The Science of Anti-Aging
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27:23Humans have long sought the fountain of youth, and recently scientists have explored the biological basis of aging and potential strategies to reverse the process. Along with groundbreaking discoveries that have enabled extending the lifespan of model organisms, the anti-aging movement has spurred an entire industry focused on stopping the biologic…
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More Than Meets the Eye: A New Portal Into Treating Brain Disorders
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13:15Disorders of the brain are among the most challenging to treat in all of medicine. Among the challenges is access: the brain is locked away in the skull, preventing medicines from reaching their destination. To deal with this difficulty, researchers are turning to an unexpected access point to the brain: the eye. In today's episode of Beyond the Ab…
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Hospital Initiatives to Transition SUD Patients from Acute Care to Community-based Services
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15:41Podcast host Shawn McNiel, MD, is joined by Noa Krawczyk, PhD, an assistant professor in the Department of Population Health at NYU Grossman School of Medicine, and an author of Initiatives to Support the Transition of Patients With Substance Use Disorders From Acute Care to Community-based Services Among a National Sample of Nonprofit Hospitals. D…
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Going Nuts About New Treatments for Food Allergies
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14:43Food allergies are a major problem – common, potentially deadly, and without effective medicines to prevent them from occurring. But earlier this year, researchers and doctors published a clinical trial reporting an effective new treatment for preventing allergic food reactions. In today’s episode of Beyond the Abstract, Derek and Dan dive into the…
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Xylazine Use Among People Who Inject Drugs, Philadelphia 2022
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13:47Xylazine Use Among People Who Inject Drugs, Philadelphia 2022 Host Shawn McNiel, MD, is joined by Marissa Tan, DO, an Epidemiology Intelligence Service (EIS) Fellow for the Center of Disease Control and Prevention through the Philadelphia Department of Public Health. Dr. Tan and her co-authors sought to help clinicians better identify individuals a…
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Xenotransplantation: How Pig Kidneys are Saving Human Lives
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13:26Thousands of patients in the US die every year waiting for an organ transplant, often because there are not enough human organ donors. Xenotransplantation — transplantation from another species to humans — could solve this problem, but has remained the realm of science fiction given many technical obstacles. Now, with advances in gene editing, this…
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From Stigma to Science: A Scientist's Journey to Treat Hyperemesis Gravidarum
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19:49While almost all women experience nausea and vomiting during pregnancy, few are debilitated by severe symptoms: a condition known as hyperemesis gravidarum (HG). HG has been stigmatized and neglected by the biomedical community, with limited research funding for developing effective treatments. In this episode of Beyond the Abstract, Derek and Dan …
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Exploring the Impact of Opioid Settlements on Addiction Medicine
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26:29Podcast host Shawn McNeil, MD, is joined by Joshua Sharfstein, MD, and Sara Whaley, MPH, from Johns Hopkins Bloomberg School of Public Health who delve into the strategic allocation of $56 billion from opioid litigation settlements. As they discuss the principles for effective fund utilization, they highlight opportunities for addiction medicine sp…
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The Way of Wegovy Part 2: Obesity Treatment and New Frontiers
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22:53A new class of medicines has transformed the treatment of obesity -- Wegovy and Ozempic have become household names. While we discussed these GLP-1 medicines on an episode of Beyond the Abstract less than a year ago, the field has progressed so quickly we thought it was already time to review many of these recent developments. In today's episode, D…
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Association of Urine Fentanyl Concentration With Severity of Opioid Withdrawal Among Patients Presenting to the Emergency Department
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12:42In episode 28 of Addiction Medicine: Beyond the Abstract, host Shawn McNeil, MD is joined my Ashish Thakrar, MD, MS, an addiction medicine specialist and Assistant Professor of Medicine with the University of Pennsylvania. Dr. Thakrar discusses the outcome of his research, which aimed to determine whether fentanyl concentration is associated with t…
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Incidence and Disparities in Use of Stigmatizing Language in Clinical Notes for Patients With Substance Use Disorder
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11:06The language used to describe people with substance use disorder impacts stigma and influences clinical decision-making. Host Dr. Shawn McNeil, MD discusses with Dr. Scott G. Weiner, MD the presence of stigmatizing language in clinical notes and detects patient- and provider-level differences. ----more---- Based on original research published in th…
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Incidence and Disparities in Use of Stigmatizing Language in Clinical Notes for Patients With Substance Use Disorder
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12:06The language used to describe people with substance use disorder impacts stigma and influences clinical decision-making. Host Dr. Shawn McNeil, MD discusses with Dr. Scott G. Weiner, MD the presence of stigmatizing language in clinical notes and detects patient- and provider-level differences. Based on original research published in the Journal of …
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ChatGPT Will See You Now: The Present and Future of AI in Medicine
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18:52Debates around artificial intelligence are everywhere: will ChatGPT usher in a new era of productivity and creativity? Or will advanced AI replace millions of workers? Doctors have similar questions about how AI may influence medicine. In today's episode of Beyond the Abstract, Dan and Derek take a deep dive into all things AI and health. They disc…
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Examining the Primary Care Experience of Patients With Opioid Use Disorder: A Qualitative Study
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18:06Examining the Primary Care Experience of Patients With Opioid Use Disorder: A Qualitative Study In episode 26 of Addiction Medicine: Beyond the Abstract, host Shawn McNeil, MD, is joined by Michael Incze, MD, MSEd. Dr. Incze is a primary care physician at the University of Utah Health Division of General Internal Medicine. He is board certified in …
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It's well known that emotions can affect the heart - we've all had an anxiety-producing thought that leads to the feeling of our heart pounding out of our chest. But what about the opposite: can the heart control our emotions? In today's episode of Beyond the Abstract, Derek and Dan discuss a fascinating new study looking at whether making the hear…
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Meet New JAM Editor-in-Chief, David A. Fiellin, MD, FASAM
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14:08Meet JAM Editor-in-Chief, David A. Fiellin, MD, FASAM Dr. Fiellin is an internist, board certified in addiction medicine. He is professor of Medicine and Emergency Medicine at Yale School of Medicine, and Public Health at Yale School of Public Health; vice chief of Faculty Affairs for the Department of Internal Medicine’s Section of General Interna…
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'Cause Baby Now We've Got Bear Blood
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19:33The effect of inappropriate blood clotting can be devastating, including heart attack and stroke. While there are many medications to reduce the risk of clotting, our understanding of why blood clots and when remains incomplete. In today’s episode of Beyond the Abstract, Derek and Dan share the remarkable story of how a team of researchers discover…
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The Key Lies with APOE: Unlocking New Treatments for Alzheimer's
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16:28Alzheimer’s disease is a devastating neurodegenerative condition affecting millions of people around the world. Current therapies are only partially effective, despite decades of research aimed at understanding the causes of the disease. Alzheimer’s is largely genetic, and the best-known genetic risk factor for Alzheimer’s comes from mutations in a…
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The Way of Wegovy: A New Drug for Weight Loss
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14:41Approximately four in 10 Americans are obese, putting millions at increased risk of developing diabetes, heart disease, liver cancer, and other chronic illnesses. For many years it’s seemed that we’re losing the battle against this modern epidemic. However, the tide may be turning with the recent approval of a revelatory new class of medications. I…
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BTS on BTA: Answering Your Questions!
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32:47Our episode today takes us Behind The Scenes (BTS) on Beyond The Abstract (BTA). Derek and Dan answer your questions on graduate school on everything from how we chose our research topics, how we deal with imposter syndrome and stress, how it feels to have finished our PhDs, and more! We hope you enjoy this change from our usual format. If you have…
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Runnin' for Clusterin: Exercise Improves Cognition
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13:00This episode is sponsored by Proteintech. Exercise is good for us - it keeps off the pounds and decreases our risk for heart attack and diabetes. What may be less known about exercise is that it's actually also good for the brain. Exercise improves memory and learning, and may even improve brain function in people with Alzheimer's disease. However,…
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The Placenta: Here for a Good Time, Not a Long Time
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16:20Preeclampsia is a pregnancy disorder characterized by high blood pressure and contributes to significant fetal and maternal deaths. However, what exactly causes preeclampsia is unclear. It's thought that preeclampsia is caused by placental dysfunction - specifically, the ability of specialized fetal cells called trophoblasts to replace and remodel …
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Surveillance System for Opioid-Associated Amnestic Syndrome
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18:09In episode twenty-four of Addiction Medicine: Beyond the Abstract, host Shawn McNeil, MD is joined by Dr. Jed Barash, a Neurologist from Massachusetts. In his paper, Dr. Barash and his colleagues discuss using an existing syndromic surveillance system to monitor for possible cases of opioid-associated amnestic syndrome in the state of Massachusetts…
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Revving Up the CAR T: Fighting Fibrosis with Gene Therapy
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19:48CAR T cells have been engineered to treat everything from cancer to scarring in the heart. However, one major barrier to wide-spread therapy is the fact that T cells have to be removed from the patient, engineered, and then putting them back in the patient. But what if we could create a drug that makes CAR T cells inside a patient's own body? This …
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COVID brain fog is a well-documented, residual symptom following COVID infection. However, how COVID infects the brain and potential causes of COVID brain fog are unclear. In this episode, Dan and Derek discuss two recent studies that show that even mild cases of COVID may have important impacts on brain structure and function. Douaud et al. SARS-C…
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HIV Preexposure Prophylaxis by Buprenorphine Prescribers
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13:00In episode twenty two of Addiction Medicine: Beyond the Abstract, host Shawn McNeil, MD, is joined by Amy Kennedy, MD, MS. Dr. Kennedy is an Acting Assistant Professor of Medicine at the University of Washington and Director of GMS Addiction Medicine Program at the VA Puget Sound Healthcare System. In her paper, Dr. Kennedy discusses barriers and f…
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Not Just a Kiss: Mono Increases Risk for Multiple Sclerosis
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21:50Epstein-Barr Virus (EBV) is best known for causing mononucleiosis, or the 'kissing disease,' in teenagers. Almost all adults get EBV at some point in their lives, even if they don't get mono. New research shows that EBV infection may have longer-lasting impacts. Using data from the American military, researchers now show that EBV infection drastica…
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Racial-ethnic Differences in Misuse of Prescription Medications
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14:34February 14, 2022In episode twenty-three of Addiction Medicine: Beyond the Abstract, host Shawn McNeil, MD is joined by Catalina Lopez-Quintero, MD, PhD, MPH. Dr. Lopez-Quintero is an Assistant Professor of Epidemiology at the University of Florida. In her paper, Dr. Lopez-Quintero discusses racial-ethnic differences in reasons for misuse of prescr…
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Hair greying is thought to be an irreversible event related to life stress, but the process has never been extensively studied. For the first time, researchers at Columbia University use novel techniques with hair imaging and a daily diary to demonstrate that hair greying is not only associated with stressful life events, but that the process is re…
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Mind the Placenta: Linking Placenta Dysfunction to Autism
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18:01The placenta is a transient organ of pregnancy that supports fetal growth and organ development. Placental dysfunction underlies many developmental defects, but this connection is poorly understood. Furthermore, many neuropsychiatric disorders, such as autism spectrum disorder, are linked to altered brain development and are more common in men than…
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The Spice is Right: Mobilizing Stem Cells with Capsaicin
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13:11Bone marrow stem cell transplants are some of the most important tools in treating diseases like leukemia and multiple myeloma. However, harvesting enough stem cells for transplantation is often a big issue for doctors. Finding new ways to elicit stem cell mobilization from the bone marrow to improve harvesting could go a long way in improving trea…
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Vibin' Myelin: A Vaccine for Multiple Sclerosis
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20:20Multiple Sclerosis (MS) is a devastating autoimmune disease that result from the immune system attacking parts of the nervous system. For a long time, MS has been treated with broad immunosuppression using corticosteroids that puts the patient at risk for infections, but this might soon change. In today's Beyond the Abstract episode, Derek and Dan …
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Rejection of Referrals Based on Substance Use Diagnosis and Treatment
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11:49Addiction Medicine: Beyond the Abstract (Episode 21). Host Shawn McNeil, MD, is joined by Simeon Kimmel, MD, who discusses a trend of referral rejections for post-acute medical care among patients with substance use disorders and patients receiving opioid agonist treatment Dr. Kimmel (@simkimmel) is an Assistant Professor of Medicine at Boston Univ…
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High cholesterol and clogged arteries are the main cause of heart attacks. While modern medicine has developed ways to keep cholesterol down, these medications must be taken daily in order to be effective and come with their own list of side effects. This is where CRISPR comes in. Scientists have now developed a way to safely and durably reduce cho…
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When patients have low oxygen levels, doctors use various types of breathing machines to deliver oxygen to the lungs - but it's not always effective. Now, scientists have taken inspiration from a small fish called the loach and developed a method to deliver oxygen through... the butt. This is particularly pertinent in the face of the COVID-19 pande…
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Mitochondria are known as the powerhouse of the cell because of their important function in producing energy. During cell division (also known as mitosis), a cell has to duplicate everything from its DNA to proteins to organelles - including mitochondria - and distribute them equally between two cells. However, no one really knows how exactly these…
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Patient-Centeredness of Addiction Treatment Intake
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10:12In episode 20 of Addiction Medicine: Beyond the Abstract, we are joined by Tami Mark, PhD. She is a Senior Fellow of Behavioral Health Financing and Quality Measurement for RTI International. Dr. Mark discusses patient placement criteria for addiction treatment and multidimensional assessments, which was published in the March/April 2021 issue of J…
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Spilling the CAR-T on Cardiac Fibrosis
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20:40Chimeric antigen receptor (CAR) T cell therapy has revolutionized cancer treatment by engineering our own immune cells to recognize and fight cancers that are resistant to treatments like radiation and chemotherapy. But can we use CAR T cells to treat other diseases too, like cardiac fibrosis? Cardiac fibrosis, or scarring of the heart, is common f…
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Sex Differences Among Adults With Opioid Use Disorder
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11:52In episode 19 of Addiction Medicine: Beyond the Abstract, we are joined by MacKenzie Peltier, PhD. She is an Assistant Professor of Psychiatry at Yale School of Medicine. In her paper, Dr. Peltier discusses sex-specific vulnerabilities observed among individuals with opioid use disorder.بقلم Shawn McNeil, MD
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Let's Talk About Sex-Biased Diseases
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29:52Why do some diseases affect more men than women, or more women than men? Science has been unable to explain many of these sex-biased diseases until just recently. In this episode of Beyond the Abstract, Derek invites Dan Weiner, an MD/PhD student at Harvard Medical School, to talk about a recent breakthrough in neuropsychiatric and autoimmune genet…
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Avoiding NICU for Newborns With Neonatal Opioid Withdrawal Syndrome
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9:56Journal of Addiction Medicine Journal of Addiction Medicine. 14(5):401-408, September/October 2020In episode eighteen of Addiction Medicine: Beyond the Abstract, we are joined by Kimberly Spence, MD. She is an Associate Professor of Pediatrics at the Saint Louis University School of Medicine. In her paper, Dr. Spence discusses the benefits of treat…
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Computerized CBT for Substance Use Disorders
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13:36Journal of Addiction Medicine In episode seventeen of Addiction Medicine: Beyond the Abstract, we are joined by Kathleen Carroll, PhD. She is the Albert E. Kent Professor of Psychiatry at Yale University School of Medicine. In her paper, Dr. Carroll discusses the feasibility of implementing computer-based treatments for substance use disorders in p…
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This week on Beyond the Abstract, Derek and Ellen talk about Derek's newest first-author publication in Developmental Biology. They discuss the role of myosin in Sertoli cells and how mutations can affect male fertility. More importantly, Ellen recounts a science celebrity sighting from our time working at the NIH. This article was featured as the …
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Antibodies, Mutations, and Sewage... Oh My!
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18:45Do declining antibodies to SARS-CoV-2 mean long-lasting immunity is impossible? What do mutations in the virus mean for vaccine effectiveness? Can we use sewage water to monitor the pandemic? On this episode of Beyond the Abstract, Derek and Ellen talk about three recent papers related to these important COVID-19 issues. Note: Since recording this …
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After a short break, Derek and Ellen are BACK with a quick update episode! They discuss New Years resolutions, COVID, grad school progress, TV shows watched, and more. Stay tuned for more episodes discussing the latest, cutting-edge research in a way that just about anyone can understand.بقلم Beyond the Abstract
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