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Featuring articles on mRNA Covid-19 vaccine safety in pregnant persons, hypothermia or normothermia after cardiac arrest, rituximab vs. mycophenolate mofetil for pemphigus, sudden cardiac death in persons with HIV, and SARS-CoV-2 vaccine design; a review article on infections in patients with cirrhosis; a case report of a man with cough, fever, and…
 
Featuring articles on wolbachia-infected mosquito deployments for dengue, Ad26.COV2.S vaccine efficacy against Covid-19, thrombotic thrombocytopenia after ChAdOx1 nCoV-19 vaccination, variant SARS-CoV-2 infection after vaccination, and on diabetes treatment and control in U.S. adults from 1999 to 2018; a review article on recent advances in the tre…
 
Featuring articles on left atrial appendage occlusion during cardiac surgery, thrombosis after ChAdOx1 nCoV-19 vaccination, adjuvant nivolumab for invasive urothelial carcinoma, a meningococcal X vaccine in Mali, and irritable bowel syndrome and immunity; a review article on HIV infection; a Clinical Problem-Solving describing a hypertensive heartb…
 
Featuring articles on aspirin dosing in cardiovascular disease, antibiotic therapy for prosthetic joint infection, gene therapy for adenosine deaminase deficiency, a novel microRNA in acute myocarditis, and immediate “kangaroo mother care” of low-birth-weight infants; a review article on somatic mutations in “benign” disease; a case report of a wom…
 
Featuring articles on efficacy of the ChAdOx1 nCoV-19 vaccine against the B.1.351 variant, NVX-CoV2373 vaccine efficacy against B.1.351 in South Africa, endovascular therapy for basilar-artery stroke, intensive or standard blood-pressure control, and on gene editing for congenital neutropenia; a review article on monoclonal gammopathy of renal sign…
 
Featuring articles on tympanostomy tubes for recurrent acute otitis media; tezepelumab in severe, uncontrolled asthma; BRAF inhibition plus rituximab in hairy-cell leukemia; an adenovirus-based Covid-19 vaccine; and deconstructing inequities; a review article on management of the difficult airway; a case report of a woman with fever and pancytopeni…
 
In this episode of Curbside Consults, we discuss thyroid disorders in pregnancy with Dr. Spyridoula Maraka, Assistant Professor of Medicine at the University of Arkansas for Medical Sciences, Staff Physician at the Central Arkansas Veterans Healthcare System, and...بقلم NEJM Group
 
An internist at Massachuetts General Hospital, Dr. Joseph Betancourt also runs their program on equity and community health. In this, the final entry in our four-interview exploration of race and clinical equity, Betancourt talks about the need for medical institutions to pay attention to what’s happening in their patients’ communities. To that end…
 
Dr. Sheares talks about her experience with inequities. She believes that clinicians should aspire to be students of their patients as well as of the pathophysiology of the diseases their patients present with. Listen in. Running time: 20 minutes The post Podcast 277: Race and clinical equity — know your patients — a conversation with Karen Dorsey …
 
In this, our second conversation on race and clinical equity, Dr. Karol Watson of UCLA offers her observations on what she’s observed as a cardiologist trying to deal with treatment plans for patients who’ve lost their health insurance or have had to go to a plan that doesn’t cover what’s needed. She reminds us that tagging people as “non-compliant…
 
We’ve conducted a set of four interviews with physicians on the topic of race and clinical equity. The conversations center not so much on their published research, but on the roles that these physicians take in their organizations and, in addition, the stories they tell about their own experiences. Our first is with Dr. Kimberly Manning, who’s a p…
 
Welcome to another episode of Curbside Consults! As part of our series on Inclusivity in Medicine and to honor Women’s History Month, we are focusing on women in clinical trials. We are joined by Dr. Janine Clayton, an ophthalmologist and Director of the National...بقلم NEJM Group
 
As part of our Curbside Consults series on Inclusivity in Medicine, we are joined by Dr. Sarah Kimball to discuss the relation among healthcare systems, social distance, and migrant patients. Dr. Kimball is an Internist and Assistant Professor at Boston University School of Medicine...بقلم NEJM Group
 
In this episode of Curbside Consults, we discuss the diagnosis and management of primary, secondary, and tertiary hyperparathyroidism with Dr. O.P. Hamnvik, who is an endocrinologist and educator at the Brigham and Women’s Hospital in Boston and the NEJM Group...بقلم NEJM Group
 
As part of our “Inclusivity in Medicine” series of Curbside Consults, we are joined by Dr. Samantha Meints, Clinical Pain Psychologist in the Department of Anesthesiology and Pain Medicine at Brigham and Women's Hospital, to discuss racial disparities in the assessment...بقلم NEJM Group
 
Inhibitors of sodium–glucose cotransporter 2 (SGLT2) are known to improve cardiovascular and renal outcomes in patients with type 2 diabetes. Until recently, less was known about the effects of SGLT2 inhibitors on heart failure. In this episode of Curbside Consults, we...بقلم NEJM Group
 
Apologies for the long silence. We have been off doing other things — one of which has been figuring out how to cover conferences. Last month, after much preparation, we covered the American Society of Hematology (ASH) annual conference; our second foray consists of brief coverage of the American Society of Clinical Oncology (ASCO) gastrointestinal…
 
The COVID-19 pandemic has exposed the magnitude of health inequities that exist today. In this Curbside Consults as part of our “Inclusivity in Medicine” series, Dr. Jim O’Connell, President of the Boston Healthcare for the Homeless Program joins us to discuss how the...بقلم NEJM Group
 
Patients who clinically deteriorate on medical and surgical wards suffer substantial morbidity and mortality. Identifying patients who are at risk for clinical deterioration provides an opportunity for early intervention. Complex automated models that use the vast data...بقلم NEJM Group
 
Obesity is a major cause of morbidity in the United States and many other high-income countries. Its association with diabetes, hypertension, cardiovascular disease, and ultimately reduced life expectancy is well known. A healthy diet and regular exercise can prevent...بقلم NEJM Group
 
In this special episode of Curbside Consults, we interview Dr. Elissa Falconer, the team leader of the NEJM Resident 360 QI Challenge winning submission. Dr. Falconer is a general surgery resident at Atlanta VA Healthcare System. The title of their quality improvement...بقلم NEJM Group
 
Eric Rubin is editor-in-chief of the New England Journal of Medicine. I asked him how COVID-19 has affected that journal, which has been around since the War of 1812 and seen its share of pandemics. Listen in — it’s the first in a planned series of interviews with the editors of the principal clinical journals. Running time: 19 minutes NEJM’s Covid…
 
The coronavirus pandemic has meant that for one of the first times ever, the entire world is experiencing the same thing at the same time. It has given me pause to think though, isn’t this exactly what climate change has been trying to highlight all along- that climate...بقلم NEJM Group
 
Dr. Paul Sax writes the closest thing that the NEJM Group has to humor. He’s serious, of course, since his blog “HIV and ID Observations” concerns all things infectious . But he sprinkles in the odd cartoon or links to … dog videos, fer cryin’ out loud. He scours the ID literature (and we must include the social-media literature in that category) f…
 
Back in late March (people often tell me that, these days, 4 months ago might as well be 4 years ago) we talked with emergency physician Julian Flores, who was working out of Broward County. Covid-19 cases were modest in number but threatening to get worse, and indeed they did. The county’s cases jumped 100-fold, from about 600 to over 50,000. Just…
 
Don’t expect HIPAA regulations to protect your “digital health footprint” from prying eyes. Every time you swipe your card to buy goodies at the supermarket (are you risking diabetes with all that ice cream?), or binge-watch that kinky series (how’s your mental health these days, really?), or let your step-tracker show you’ve fallen off the pace (c…
 
The COVID-19 pandemic has forced innovation in health care in many ways, one of which is putting to test advances in digital health. There has been no better time to test its value than in this environment of social distancing, reduced contact, and heightened health...بقلم NEJM Group
 
We interview Dr. Michael Gonzalez, a Houston-based emergency physician, who describes the situation there as “an ongoing, slow-rolling, level 6 hurricane that just isn’t gonna go away and, more importantly, isn’t gonna tell us when landfall is coming and when it’s gonna be over.” How are his patients reacting to this surge? What does he do to prepa…
 
This time Dr. Ali Raja and Joe Elia talk with two authors of a study that found disparate effects on traffic deaths from the legalization of recreational cannabis. The two states under study, Colorado and Washington, were compared, not with each other, but with a composite of states that most closely resembled what Colorado and […] The post Podcast…
 
In this episode of Curbside Consults: Statistical Review, we explore the interpretation of secondary outcomes in clinical trials using the following two articles recently published in NEJM: Bonaca MP et al. Rivaroxaban in Peripheral Artery Disease after Revascularization...بقلم NEJM Group
 
In today’s podcast we are joined by Dr. Marc Bonaca to discuss the findings of the recent VOYAGER PAD trial and the use of low-dose rivaroxaban in peripheral artery disease after revascularization.بقلم NEJM Group
 
The novel coronavirus obviously has devastating effects on the lungs, but other, less immediately visible attacks occur — notably to the kidneys. Dr. Steven Fishbane (a nephrologist) and his colleagues have just published their findings based on a survey of some 5500 patients with COVID-19 admitted to a metropolitan New York health system. Acute ki…
 
A combination of three antivirals — Kaletra (which is lopinavir plus ritonavir) and ribavirin — when given early and with interferon significantly reduces viral shedding, disease symptoms, and hospital stay in patients with COVID-19 when compared with a control regimen of Kaletra alone. The drugs are active against other coronaviruses, but the key …
 
We (Dr. Danielle Bowen Scheurer and Joe Elia) talk with Dr. John Jernigan of the CDC COVID-19 Investigation Team, which recently published its findings on the spread of COVID-19 in a Seattle-area skilled nursing facility. Most intriguingly, over half the patients who tested positive were asymptomatic at the time of their first testing, and a few [……
 
Cardiovascular consults are way down. Is the threat of COVID-19 infection scaring people away from EDs? We caught up with Dr. Comilla Sasson, the American Heart Association’s VP for science and innovation. She’s an emergency physician who teaches at the University of Colorado. She’d traveled to New York City to “help with the response,” and she […]…
 
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